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達比加群 - Revision history
2026-06-22T13:31:13Z
Revision history for this page on the wiki
MediaWiki 1.43.0
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Zeki: /* 用藥須知 */
2024-07-08T07:34:34Z
<p><span class="autocomment">用藥須知</span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 03:34, 8 July 2024</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''兒童及長者</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''兒童及長者</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>兒童安全性和有效性尚未確立；老年人出血風險增加</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>兒童安全性和有效性尚未確立；老年人出血風險增加</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
</table>
Zeki
https://www.sehk-wiki.org/index.php?title=%E9%81%94%E6%AF%94%E5%8A%A0%E7%BE%A4&diff=4043&oldid=prev
Zeki: /* 常見問題 */
2024-07-08T06:18:06Z
<p><span class="autocomment">常見問題</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:18, 8 July 2024</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l97">Line 97:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==常見問題==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==常見問題==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''如何服用片劑？</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''如何服用片劑？</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>整粒吞服膠囊，配水服用，可以空腹或飯後服用。不要打開、弄碎或咀嚼膠囊</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>整粒吞服膠囊，配水服用，可以空腹或飯後服用。不要打開、弄碎或咀嚼膠囊</div></td></tr>
</table>
Zeki
https://www.sehk-wiki.org/index.php?title=%E9%81%94%E6%AF%94%E5%8A%A0%E7%BE%A4&diff=4042&oldid=prev
Zeki: /* 藥物動力學 */
2024-07-08T06:17:47Z
<p><span class="autocomment">藥物動力學</span></p>
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<col class="diff-marker" />
<col class="diff-content" />
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:17, 8 July 2024</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l62">Line 62:</td>
<td colspan="2" class="diff-lineno">Line 62:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*吸收</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*吸收</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**血漿峰值時間1至2小時</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**血漿峰值時間1至2小時</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*代謝**轉化為活性形式達比加群</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*代謝</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*排泄**</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>**轉化為活性形式達比加群</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>主要通過腎臟（80%），</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*排泄</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>**主要通過腎臟（80%），</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*半衰期</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*半衰期</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**12至17小時</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>**12至17小時</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*藥物作用持續時間</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*藥物作用持續時間</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>12至 17小時（每天兩次給藥）</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">**</ins>12至 17小時（每天兩次給藥）</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==用藥須知==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==用藥須知==</div></td></tr>
</table>
Zeki
https://www.sehk-wiki.org/index.php?title=%E9%81%94%E6%AF%94%E5%8A%A0%E7%BE%A4&diff=4041&oldid=prev
Zeki: /* 副作用 */
2024-07-08T06:17:26Z
<p><span class="autocomment">副作用</span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:17, 8 July 2024</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l46">Line 46:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>| 腹瀉</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>| 腹瀉</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">**</del>|-</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|輕微出血</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|輕微出血</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|-</div></td></tr>
</table>
Zeki
https://www.sehk-wiki.org/index.php?title=%E9%81%94%E6%AF%94%E5%8A%A0%E7%BE%A4&diff=4037&oldid=prev
Zeki: Created page with "Category: 直接凝血酶抑制劑 '''口服抗凝血藥物''' '''藥物類別：:Category: 直接凝血酶抑制劑 | 直接凝血酶抑..."
2024-07-08T05:33:01Z
<p>Created page with "<a href="/index.php/Category:%E7%9B%B4%E6%8E%A5%E5%87%9D%E8%A1%80%E9%85%B6%E6%8A%91%E5%88%B6%E5%8A%91" title="Category:直接凝血酶抑制劑">Category: 直接凝血酶抑制劑</a> <a href="/index.php/Category:%E6%8A%97%E5%87%9D%E8%A1%80%E8%97%A5" title="Category:抗凝血藥"> '''口服抗凝血藥物'''</a> '''藥物類別：:Category: 直接凝血酶抑制劑 | 直接凝血酶抑..."</p>
<p><b>New page</b></p><div>[[Category: 直接凝血酶抑制劑]]<br />
<br />
[[:Category: 抗凝血藥 | '''口服抗凝血藥物''']]<br />
<br />
'''藥物類別：[[:Category: 直接凝血酶抑制劑 | 直接凝血酶抑制劑]]<br />
<br />
'''達比加群''' (English: [[Dabigatran]])<br />
==常見劑量==<br />
75 毫克、110 毫克和 150 毫克膠囊<br />
<br />
==藥物商品名稱==<br />
PRADAXA 普栓達<br />
<br />
==藥物用途==<br />
*預防非瓣膜性心房顫動患者的中風和全身栓塞<br />
*治療和預防深部靜脈血栓（DVT）和肺栓塞（PE）<br />
*預防髖關節或膝關節置換手術後的血栓形成<br />
<br />
==作用機制==<br />
直接抑制凝血酶，防止血栓形成<br />
<br />
==給藥途徑==<br />
口服<br />
<br />
==劑量==<br />
*心房顫動患者：每天兩次，每次 150 毫克<br />
根據 eGFR 的腎功能劑量調整：<br />
*eGFR >50 mL/min：無需調整劑量，標準劑量為每天兩次，每次 150 毫克<br />
*eGFR 30-50 mL/min：<br />
**用於預防心房顫動引起的中風：每天兩次，每次75毫克<br />
**用於治療深靜脈血栓/肺栓塞：每天兩次，每次150毫克，但需謹慎使用<br />
*eGFR 15-30 mL/min：用於預防心房顫動引起的中風，每天兩次，每次75毫克<br />
*eGFR <15 mL/min：避免使用<br />
<br />
==副作用==<br />
{| class="wikitable"<br />
!style="text-align: left"| 頻率<br />
!不良反應<br />
|-<br />
| rowspan="5" | '''常見<br />
| 消化不良<br />
|-<br />
| 胃灼熱<br />
|-<br />
| 腹痛<br />
|-<br />
| 腹瀉<br />
**|-<br />
|輕微出血<br />
|-<br />
| rowspan="4" | '''不常見<br />
| 噁心、嘔吐<br />
|-<br />
| 嚴重胃灼熱<br />
|-<br />
| 大出血<br />
|-<br />
| 顱內出血<br />
|}<br />
<br />
==藥物動力學==<br />
*吸收<br />
**血漿峰值時間1至2小時<br />
*代謝**轉化為活性形式達比加群<br />
*排泄**<br />
主要通過腎臟（80%），<br />
*半衰期<br />
**12至17小時<br />
*藥物作用持續時間<br />
12至 17小時（每天兩次給藥）<br />
<br />
==用藥須知==<br />
'''懷孕<br />
<br />
不建議使用<br />
<br />
'''母乳餵哺<br />
<br />
不建議使用<br />
<br />
'''兒童及長者<br />
兒童安全性和有效性尚未確立；老年人出血風險增加<br />
<br />
'''監測要求<br />
<br />
腎功能、出血跡象<br />
<br />
'''藥物相互作用<br />
<br />
P-糖蛋白抑制劑、抗凝血劑、非類固醇消炎藥、抗血小板藥物<br />
<br />
'''警告<br />
*老年人及低體重患者慎用<br />
*出血性疾病、胃炎、食道逆流患者慎用<br />
<br />
==常見問題==<br />
'''如何服用片劑？<br />
<br />
<br />
整粒吞服膠囊，配水服用，可以空腹或飯後服用。不要打開、弄碎或咀嚼膠囊<br />
<br />
'''服用期間應避免什麼？<br />
<br />
增加出血或受傷風險的活動<br />
<br />
'''若錯過一劑該怎辦？<br />
<br />
如果距離下一次服藥時間超過6小時，請盡快服用。如果不到6小時，跳過漏服的劑量，按原定計劃服用下一劑</div>
Zeki