Alogliptin - Revision history

Helen: /* Drug Trade Name of Alogliptin */

2024-07-05T01:53:59Z

Drug Trade Name of Alogliptin

← Older revision		Revision as of 21:53, 4 July 2024
Line 14:		Line 14:
	It is also sold under various brand names when combined with other antidiabetic medications, such as:		It is also sold under various brand names when combined with other antidiabetic medications, such as:
	*NESINA MET TABLET 12.5MG/1000MG: Alogliptin 12.5mg + Metformin 1000mg		*NESINA MET TABLET 12.5MG/1000MG: Alogliptin 12.5mg + Metformin 1000mg
	*NESINA MET TABLET 12.5MG/500MG: Alogliptin 12.5mg + Metformin ~~10500mg~~		*NESINA MET TABLET 12.5MG/500MG: Alogliptin 12.5mg + Metformin 1000mg
	*OSENI TABLET 25MG/15MG: Alogliptin 25mg + Pioglitazone 15mg		*OSENI TABLET 25MG/15MG: Alogliptin 25mg + Pioglitazone 15mg
	*OSENI TABLET 25MG/30MG: Alogliptin 25mg + Pioglitazone 30mg		*OSENI TABLET 25MG/30MG: Alogliptin 25mg + Pioglitazone 30mg

Zeki at 07:16, 4 July 2024

2024-07-04T07:16:16Z

Show changes

Zeki: /* Drug Trade Name of Alogliptin */

2024-07-04T07:00:39Z

Drug Trade Name of Alogliptin

← Older revision		Revision as of 03:00, 4 July 2024
Line 11:		Line 11:

	==Drug Trade Name of Alogliptin==		==Drug Trade Name of Alogliptin==
	~~Alogliptin~~ is ~~marketed~~ under ~~several trade name~~, ~~including~~:		*Nesina, Vipidia, Oseni
	*~~Nesina~~		It is also sold under various brand names when combined with other antidiabetic medications, such as:
	*~~Vipidia~~		*NESINA MET TABLET 12.5MG/1000MG: Alogliptin 12.5mg + Metformin 1000mg
	*~~Kazano (when combined with metformin)~~		*NESINA MET TABLET 12.5MG/500MG: Alogliptin 12.5mg + Metformin 10500mg
	*~~Oseni (when combined with pioglitazone)~~		*OSENI TABLET 25MG/15MG: Alogliptin 25mg + Pioglitazone 15mg
			*OSENI TABLET 25MG/30MG: Alogliptin 25mg + Pioglitazone 30mg

	==Mechanism of Action==		==Mechanism of Action==

Zeki: /* Common Strengths of Alogliptin */

2024-07-04T06:59:42Z

Common Strengths of Alogliptin

← Older revision		Revision as of 02:59, 4 July 2024
Line 8:		Line 8:
	==Common Strengths of Alogliptin==		==Common Strengths of Alogliptin==
	Alogliptin is available in the following strengths:		Alogliptin is available in the following strengths:
	*6.25 mg		*6.25 mg, 12.5 mg, 25 mg tablets
	*12.5 mg
	*25 mg

	==Drug Trade Name of Alogliptin==		==Drug Trade Name of Alogliptin==

Zeki at 06:52, 4 July 2024

2024-07-04T06:52:13Z

← Older revision		Revision as of 02:52, 4 July 2024
Line 1:		Line 1:
	[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]		[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

	'''Alogliptin''' ~~(中文：~~[[阿格列汀]])		[[:Category: Antidiabetic Drug \| '''Antidiabetic Drug''']]

			'''Drug class: [[:Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor \| Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

			'''Alogliptin (NESINA)'''（中文：[[阿格列汀]]）
	==Common Strengths of Alogliptin==		==Common Strengths of Alogliptin==
	Alogliptin is available in the following strengths:		Alogliptin is available in the following strengths:

Zeki at 03:28, 24 June 2024

2024-06-24T03:28:39Z

← Older revision		Revision as of 23:28, 23 June 2024
Line 1:		Line 1:
	[[Category: Drugs]]		[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

	'''Alogliptin''' (中文：[[阿格列汀]])		'''Alogliptin''' (中文：[[阿格列汀]])

Zeki at 01:45, 24 June 2024

2024-06-24T01:45:53Z

← Older revision		Revision as of 21:45, 23 June 2024
Line 1:		Line 1:
			[[Category: Drugs]]

	'''Alogliptin''' (中文：[[阿格列汀]])		'''Alogliptin''' (中文：[[阿格列汀]])
	==Common Strengths of Alogliptin==		==Common Strengths of Alogliptin==

Zeki: Created page with "'''Alogliptin''' (中文：阿格列汀) ==Common Strengths of Alogliptin== Alogliptin is available in the following strengths: 6.25 mg 12.5 mg *25 mg ==Drug Trade Name..."

2024-06-24T01:45:18Z

Created page with "'''Alogliptin''' (中文：阿格列汀) ==Common Strengths of Alogliptin== Alogliptin is available in the following strengths: *6.25 mg *12.5 mg *25 mg ==Drug Trade Name..."

New page

'''Alogliptin''' (中文：[[阿格列汀]])
==Common Strengths of Alogliptin==
Alogliptin is available in the following strengths:
*6.25 mg
*12.5 mg
*25 mg

==Drug Trade Name of Alogliptin==
Alogliptin is marketed under several trade name, including:
*Nesina
*Vipidia
*Kazano (when combined with metformin)
*Oseni (when combined with pioglitazone)

==Mechanism of Action==
Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by inhibiting the DPP-4 enzyme, which results in increased levels of incretin hormones. These hormones help regulate blood glucose by increasing insulin release and decreasing glucagon levels in a glucose-dependent manner.

==Route of Administration==
Alogliptin is administered orally in tablet form.

==Dosages==
*Normal People
**The usual dose is 25 mg once daily.
*Hypertension
**No specific dosage adjustment is required, but caution is advised due to potential cardiovascular effects.
*Heart Failure
**No specific dosage adjustment is required, but caution is advised due to potential cardiovascular effects.
*Diabetic Kidney Disases
**Mild renal impairment (CrCl ≥ 60 to < 90 mL/min)
***No dose adjustment required.
**Moderate renal impairment (CrCl ≥ 39 to < 60 mL/min)
***12.5 mg once daily.
**Severe renal impairment (CrCl ≥ 15 to < 30 mL/min) or end-stage renal disease (ESRD) (CrCl < 15 mL/min)
***6.25 mg once daily.

==Side Effects==
{| class="wikitable"
!style="text-align: left"| Frequency
!Adverse reactions
|-
| '''Very common (≥1/10)
| None reported
|-
| rowspan="3" | '''Common (≥1/100 to <1/10)
| Headache
|-
| Nasopharyngitis
|-
| Upper respiratory tract infection
|-
| rowspan="3" | '''Uncommon (≥1/1,000 to <1/100)
| Hypoglycemia (when used with other antidiabetic drugs)
|-
| Pruritus
|-
| Rash
|-
| rowspan="3" | '''Rare (≥1/10,000 to <1/1,000)
| Pancreatitis
|-
| Hepatic dysfunction
|-
| Hypersensitivity reaction including anaphylaxis and angioedema
|-
| '''Very Rare (<1/10,000)
| Severe cutaneous adverse reactions including Stevens-Johnson syndrome
|}

==Pharmacokinetics==
*Absorption
**Rapidly absorbed with peak plasma concentrations occurring 1 - 2 hours after dosing. The absolute bioavailability is approximately 100%.
*Distribution
**Alogliptin is 20 - 30% bound to plasma proteins
*Metabolism
**Alogliptin does not undergo extensive metabolism, 60 - 70% of the dose is excreted as unchanged drug in the urine. Limited metabolism primarily via CYP2D6 and CYP3A4.
*Elimination
**Primarily excreted unchanged in urine. The mean terminal half-life is approximately 21 hours.

==Drug Precautions==
'''Safety

Use with caution in patients with liver disease. Monitor liver functions tests regularly. Discontinue if pancreatitis or severe hypersensitivity reactions occur.

'''Pregnancy

Not recommended due to lack of sufficient data on safety.

'''Breast Feeding

Not recommended due to lack of sufficient data on safety.

'''Children and Elderly

Not recommended for children. Elderly patients should be monitored closely due to increased risk of adverse effects.

'''Renal Impairment

Dose adjustments are required for patients with moderate to severe renal impairment and ESRD.

'''Monitoring Requirements

Regular monitoring of liver function tests and renal function is recommended.

'''Drug Interaction

Caution with CYP2D6 and CYP3A4 inhibitors. Monitor for hypoglycemia when used with insulin or insulin secretagogues.

==FAQs==
'''How should I take the tablet?

Take alogliptin exactly as prescribed by your doctor, usually once daily, with or without food.

'''What should I avoid while taking?

Avoid alcohol and other medications that can affect liver function. Avoid useing alogliptin if you have a history of severe hypersensitivity reactions to DPP-4 inhibitors.

'''What happens if I miss a dose?

Take the missed dose as soon as you remember, unless it is close to the time for your next dose. Do not take two doses at one time.

==Reference==
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834733

[2] https://www.accessdata fda.gov/drugsatfda_docs/label/2015/022426s005lbl.pdf

[3] https://www.drugs.com/pro/alogliptin.html

[4] https://www.rxlist.com/alogliptin/generic-drug.htm

[5] https://n.wikipedia.org/wiki/Alogliptin