Amantadine - Revision history

Zeki at 08:06, 28 October 2024

2024-10-28T08:06:12Z

← Older revision		Revision as of 04:06, 28 October 2024
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	***Serum creatinine and blood urea nitrogen (BUN) levels.		***Serum creatinine and blood urea nitrogen (BUN) levels.
	***Estimated glomerular filtration rate (eGFR).		***Estimated glomerular filtration rate (eGFR).
			*Mental Status
			**Patients should be monitored for changes in mental status, including:
			***Hallucinations, delusions, depression, and suicidality.
			**Increased risk of neuroleptic malignant syndrome (NMS) symptoms upon abrupt discontinuation.
			*Blood Pressure
			**Blood pressure should be monitored regularly due to the risk of orthostatic hypotension, particularly in older adults.
			*Liver Function
			**Liver enzymes (AST and ALT should be checked periodically, especially in patients with liver disease or those experiencing symptoms suggestive of hepatic impairment.
			*'''Seizure Activity'''
			**For patients with a history of seizures, monitoring for seizure activity is advised as amantadine can lower the seizure threshold.

			'''Drug Interactions

			Amantadine may interact with:
			*Anticholinergic drugs (increased side effects).
			*Dopaminergic agents (potentially enhanced effects).

			==FAQ==
			'''How Should I Take the Tablet?

			Take amantadine exactly as prescribed by your healthcare provider, typically with or without food.

			'''What Should I Avoid While Taking?

			Avoid alcohol and other CNS depressants while taking amantadine due to increased risk of drowsiness.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is close to the time of your next dose. Do not double up on doses.

Zeki at 07:51, 28 October 2024

2024-10-28T07:51:39Z

← Older revision		Revision as of 03:51, 28 October 2024
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	'''Drug Monitoring Items		'''Drug Monitoring Items
	*Renal Function		*Renal Function
	**Regular assessment of renal function is critical, especially in elderly patients or those with pre-existing renal impairment. Amantadine is predominantly excreted unchanged through the kidneys, and impaired renal function can lead to increased plasma concentrations and prolonged half-life of the drug.		**Regular assessment of renal function is critical, especially in elderly patients or those with pre-existing renal impairment. Amantadine is predominantly excreted unchanged through the kidneys, and impaired renal function can lead to increased plasma concentrations and prolonged half-life of the drug. Monitoring should include:
			***Serum creatinine and blood urea nitrogen (BUN) levels.
	Monitoring should include:		***Estimated glomerular filtration rate (eGFR).
	**Serum creatinine and blood urea nitrogen (BUN) levels.
	**Estimated glomerular filtration rate (eGFR).

Zeki: Created page with "Category: DrugsCategory: Dopaminergic Antiparkinsonian agent '''Antiparkinsonian Drug''' '''Drug class: :Category: Dopaminer..."

2024-10-28T07:51:06Z

Created page with "Category: Drugs Category: Dopaminergic Antiparkinsonian agent '''Antiparkinsonian Drug''' '''Drug class: :Category: Dopaminer..."

New page

[[Category: Drugs]][[Category: Dopaminergic Antiparkinsonian agent]]

[[:Category: Antiparkinsonian Drug | '''Antiparkinsonian Drug''']]

'''Drug class: [[:Category: Dopaminergic Antiparkinsonian agent | Dopaminergic Antiparkinsonian Agent]]'''

'''Amantadine'''（中文：[[金鋼烷胺]]）
==Common Strengths==
*Tablets: 100 mg

==Drug Usage==
Amantadine is utilized for:
*Treating dyskinesia associated with Parkinson's disease.
*Managing drug-induced extrapyramidal symptoms.

==Mechanism of Action==
The exact mechanism is not fully understood, but it is believed to:
*Increase dopamine release and inhibit its reuptake.
*Act as a weak NMDA receptor antagonist, which helps in reducing dyskinesia.

==Route of Administration==
Amantadine is administered orally.

==Dosages==
*Initial Dose: 100 mg once daily; may be increased based on response.

==Side Effects==
{| class="wikitable"
!style="text-align: left"| Frequency
!Adverse reactions
|-
| rowspan="3" | '''Common Side Effects
| Dizziness
|-
| Nausea
|-
| Insonia
|-
| rowspan="3" | '''Serious Side Effects
| Congestive heary failure exacerbation
|-
| Severe skin reactions (e.g. rash)
|-
| Neuroleptic malignant syndrome
|}

==Pharmacokinetics==
*Onset Time: Effects may begin within 2 days, but full benefits can take up to 2 weeks.
*Duration: gnerally lasting 12 to 24 hours.

==Drug Precautions==
'''Pregnancy

Amantadine should be used during pregnancy only if clearly needed, as risks vs. benefits must be evaluated.

'''Breastfeeding

Excretion in breast milk is unknown; caution is advised.

'''Drug Monitoring Items
*Renal Function
**Regular assessment of renal function is critical, especially in elderly patients or those with pre-existing renal impairment. Amantadine is predominantly excreted unchanged through the kidneys, and impaired renal function can lead to increased plasma concentrations and prolonged half-life of the drug.

Monitoring should include:
**Serum creatinine and blood urea nitrogen (BUN) levels.
**Estimated glomerular filtration rate (eGFR).