Amisulpride - Revision history

Zeki: /* Drug Precautions */

2024-07-15T01:08:34Z

Drug Precautions

← Older revision		Revision as of 21:08, 14 July 2024
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	==Drug Precautions==		==Drug Precautions==
	''' Pregnancy		''' Pregnancy

	Insufficient data on use during pregnancy to establish risk		Insufficient data on use during pregnancy to establish risk

	''' Breastfeeding		''' Breastfeeding

	Contraindicated during breastfeeding		Contraindicated during breastfeeding

Zeki: /* Dosages */

2024-07-15T00:58:38Z

Dosages

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	==Dosages==		==Dosages==
	* Schizophrenia: 400-800 mg/day orally, divided into two doses.		* Schizophrenia: 400 - 800 mg/day orally, divided into two doses.

	Renal dose based on eGFR:		Renal dose based on eGFR:

Zeki: /* Mechanism of Action */

2024-07-15T00:56:20Z

Mechanism of Action

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	==Mechanism of Action==		==Mechanism of Action==
	Amisulpride is a selective dopamine D2 and D3 receptor antagonist. At low doses, it selectively binds to presynaptic dopamine autoreceptors, while at high doses, it		Amisulpride is a selective dopamine D2 and D3 receptor antagonist. At low doses, it selectively binds to presynaptic dopamine autoreceptors, while at high doses, it preferentially binds to post-synaptic dopamine receptors. This explains its effectiveness in treating both negative and positive symptoms of schizophrenia.

	preferentially binds to post-synaptic dopamine receptors. This explains its effectiveness in treating both negative and positive symptoms of schizophrenia.

	==Route of Administration==		==Route of Administration==

Zeki at 00:53, 15 July 2024

2024-07-15T00:53:57Z

← Older revision		Revision as of 20:53, 14 July 2024
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	~~[[Category: Drugs]]~~		[[Category: Drugs]][[Category: Atypical antipsychotic ]]

	[[Category: Drugs]][[Category: Atypical ~~Antipsychotic~~ ]]

	[[:Category: Antipsychotic Drug \| '''Antipsychotic Drug''']]		[[:Category: Antipsychotic Drug \| '''Antipsychotic Drug''']]

	'''Drug class: [[:Category: Atypical antipsychotic \| Atypical ~~antipsychotic~~ ]]		'''Drug class: [[:Category: Atypical antipsychotic \| Atypical Antipsychotic ]]

	'''Amisulpride (SOLIAN)'''（中文：[[氨磺必利]]）		'''Amisulpride (SOLIAN)'''（中文：[[氨磺必利]]）

Zeki at 00:53, 15 July 2024

2024-07-15T00:53:22Z

← Older revision		Revision as of 20:53, 14 July 2024
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	[[Category: Drugs]]		[[Category: Drugs]]

	[[Category: Drugs]][[Category: Atypical ~~antipsychotic~~ ]]		[[Category: Drugs]][[Category: Atypical Antipsychotic ]]

	[[:Category: Antipsychotic Drug \| '''Antipsychotic Drug''']]		[[:Category: Antipsychotic Drug \| '''Antipsychotic Drug''']]

Zeki: /* FAQ */

2024-07-11T03:10:51Z

FAQ

← Older revision		Revision as of 23:10, 10 July 2024
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	==FAQ==		==FAQ==
	'''How Should I Take the Tablet?		'''How Should I Take the Tablet?

	Swallow the tablets whole with a full glass of water. Do not chew, crush or break the tablets		Swallow the tablets whole with a full glass of water. Do not chew, crush or break the tablets

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	'''What Happens if I Miss a Dose?		'''What Happens if I Miss a Dose?

	Answer not provided in the given information. If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.		Answer not provided in the given information. If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Zeki: /* FAQ */

2024-07-11T03:10:39Z

FAQ

← Older revision		Revision as of 23:10, 10 July 2024
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	==FAQ==		==FAQ==
	'''How Should I Take the Tablet?		'''How Should I Take the Tablet?
	* Swallow the tablets whole with a full glass of water. Do not chew, crush or break the tablets		Swallow the tablets whole with a full glass of water. Do not chew, crush or break the tablets

	'''What should I avoid while taking?		'''What should I avoid while taking?
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	'''What Happens if I Miss a Dose?		'''What Happens if I Miss a Dose?
	* Answer not provided in the given information. If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the		Answer not provided in the given information. If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
	missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Zeki: /* Contraindications */

2024-07-11T03:08:59Z

Contraindications

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	* Prolactin-dependent tumors (e.g., prolactinoma, breast cancer)		* Prolactin-dependent tumors (e.g., prolactinoma, breast cancer)
	* Movement disorders (e.g., Parkinson's disease, dementia with Lewy bodies)		* Movement disorders (e.g., Parkinson's disease, dementia with Lewy bodies)


	==FAQ==		==FAQ==

Zeki: /* Drug Precautions */

2024-07-11T03:08:27Z

Drug Precautions

← Older revision		Revision as of 23:08, 10 July 2024
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	==Drug Precautions==		==Drug Precautions==
	''' Pregnancy		''' Pregnancy
	*Insufficient data on use during pregnancy to establish risk		Insufficient data on use during pregnancy to establish risk

	''' Breastfeeding		''' Breastfeeding
	*Contraindicated during breastfeeding		Contraindicated during breastfeeding

	'''Children and Elderly		'''Children and Elderly

Zeki: /* Drug Precautions */

2024-07-11T03:07:58Z

Drug Precautions

← Older revision		Revision as of 23:07, 10 July 2024
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	==Drug Precautions==		==Drug Precautions==
	~~'''Increased risk in elderly patients~~

	*Should not be used to treat dementia-related psychosis in older adults due to increased risk of stroke and death
	*May cause drowsiness, dizziness, and difficulty swallowing in elderly patients, increasing the risk of falls and choking

	''' Pregnancy		''' Pregnancy
	*Insufficient data on use during pregnancy to establish risk		*Insufficient data on use during pregnancy to establish risk
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	*Contraindicated during breastfeeding		*Contraindicated during breastfeeding

	'''Children ~~& Adult~~		'''Children and Elderly
	*Not recommended for use in children under 18 years old		*Not recommended for use in children under 18 years old
			*Should not be used to treat dementia-related psychosis in older adults due to increased risk of stroke and death
			*May cause drowsiness, dizziness, and difficulty swallowing in elderly patients, increasing the risk of falls and choking

			'''Renal Imapirment

	~~'''Renal impairment~~		Dose adjustments are necessary for patients with renal insufficiency.
	*Dose adjustments are necessary for patients with renal insufficiency

	'''QT Prolongation		'''QT Prolongation
	*Amisulpride can cause dose- and concentration-dependent prolongation of the QT interval, which can lead to serious ventricular arrhythmias like torsades de pointes. It
	should be avoided in patients with congenital long QT syndrome and those taking other drugs that prolong the QT interval (e.g., droperidol, ondansetron)		Amisulpride can cause dose- and concentration-dependent prolongation of the QT interval, which can lead to serious ventricular arrhythmias like torsades de pointes. It should be avoided in patients with congenital long QT syndrome and those taking other drugs that prolong the QT interval (e.g., droperidol, ondansetron).

	'''Abrupt Withdrawal		'''Abrupt Withdrawal
	*Should not be stopped abruptly to avoid withdrawal symptoms such as nausea, vomiting, insomnia, and the recurrence of psychotic symptoms
			Should not be stopped abruptly to avoid withdrawal symptoms such as nausea, vomiting, insomnia, and the recurrence of psychotic symptoms

	'''Monitoring Requirements		'''Monitoring Requirements
	* Blood glucose monitoring as it may cause elevated blood glucose levels.		*Blood glucose monitoring as it may cause elevated blood glucose levels.
	* ECG Monitoring: Recommended for patients with preexisting arrhythmias, cardiac conduction disorders, electrolyte imbalances (e.g., hypokalemia, hypomagnesemia), and		*ECG Monitoring: Recommended for patients with preexisting arrhythmias, cardiac conduction disorders, electrolyte imbalances (e.g., hypokalemia, hypomagnesemia), and congestive heart failure.
	congestive heart failure.

	'''Drug ~~Interactions~~		'''Drug Interaction
	* Dopamine Agonists: Reciprocal antagonism with dopamine agonists (e.g., levodopa); concurrent use should be avoided.		*Dopamine Agonists: Reciprocal antagonism with dopamine agonists (e.g., levodopa); concurrent use should be avoided.
	* Other QT-Prolonging Drugs: Avoid coadministration with other drugs known to prolong the QT interval.		*Other QT-Prolonging Drugs: Avoid coadministration with other drugs known to prolong the QT interval.

	==Contraindications==		==Contraindications==