Amlodipine - Revision history

Zeki at 02:59, 5 September 2024

2024-09-05T02:59:59Z

← Older revision		Revision as of 22:59, 4 September 2024
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	'''Drug class: [[:Category: Calcium-channel Blocker, CCB \| Calcium-channel Blocker, CCB]]		'''Drug class: [[:Category: Calcium-channel Blocker, CCB \| Calcium-channel Blocker, CCB]]

	'''Amlodipine'''（中文：[[氨氯地平]]）is a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.		'''Amlodipine (NORVASC)'''（中文：[[氨氯地平]]）is a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.

	==Pronunciation==		==Pronunciation==

2024-09-05T02:31:30Z

← Older revision		Revision as of 22:31, 4 September 2024
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	'''Drug class: [[:Category: Calcium-channel Blocker, CCB \| Calcium-channel Blocker, CCB]]		'''Drug class: [[:Category: Calcium-channel Blocker, CCB \| Calcium-channel Blocker, CCB]]

	'''Amlodipine'''~~(中文:~~[[氨氯地平]]~~) is~~ a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.		'''Amlodipine'''（中文：[[氨氯地平]]）is a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.

	==Pronunciation==		==Pronunciation==

2024-09-05T02:31:03Z

← Older revision		Revision as of 22:31, 4 September 2024
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	[[Category: Drugs]] [[Category: Calcium-channel Blocker, CCB]]		[[Category: Drugs]][[Category: Calcium-channel Blocker, CCB]]

			[[:Category: Cardiovascular Drug \| '''Cardiovascular Drug''']]

			'''Drug class: [[:Category: Calcium-channel Blocker, CCB \| Calcium-channel Blocker, CCB]]

	'''Amlodipine'''(中文:[[氨氯地平]]) is a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.		'''Amlodipine'''(中文:[[氨氯地平]]) is a dihydropyridine calcium-channel blocker. It is used in the management of hypertension and angina.


	==Pronunciation==		==Pronunciation==

2022-08-22T06:24:23Z

Side Effects

← Older revision		Revision as of 02:24, 22 August 2022
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	\|dyspnoea		\|dyspnoea
	\|-		\|-
	\|'''Gastro-intestinal disorders		\| rowspan="2" \|'''Gastro-intestinal disorders
	\|Common		\|Common
	\|Abdominal pain, nausea, dyspepsia, altered bowel habits (including diarrhoea and constipation)		\|Abdominal pain, nausea, dyspepsia, altered bowel habits (including diarrhoea and constipation)
	\|-		\|-
	\|
	\|Very rare		\|Very rare
	\|Gingival hyperplasia		\|Gingival hyperplasia

2022-08-22T06:24:10Z

Side Effects

← Older revision		Revision as of 02:24, 22 August 2022
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	\|Visual disturbance (including diplopia)		\|Visual disturbance (including diplopia)
	\|-		\|-
	\|'''Cardiac disorders		\| rowspan="2" \|'''Cardiac disorders
	\|Common		\|Common
	\|palpitations		\|palpitations
	\|-		\|-
	\|
	\|Uncommon		\|Uncommon
	\|Arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation)		\|Arrhythmia (including bradycardia, ventricular tachycardia and atrial fibrillation)

2022-08-04T03:58:22Z

← Older revision		Revision as of 23:58, 3 August 2022
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	\|cardiogenic shock, significant aortic stenosis, unstable angina		\|cardiogenic shock, significant aortic stenosis, unstable angina
	\|}		\|}

			== FAQ ==
			==== How should I take the tablet? ====
			You will usually take amlodipine once a day. You can take it at any time of day, but try to make sure it is around the same time every day.
			You can take amlodipine with or without food.

			==== What should I avoid while taking? ====
			Avoid eating grapefruit or drinking grapefruit juice while taking amlodipine.
			Grapefruit juice can increase amlodipine in your body and make side effects worse, such as feeling dizzy, flushing or getting headaches.

2022-08-04T03:56:58Z

Pharmacokinetics

← Older revision		Revision as of 23:56, 3 August 2022
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	{\|class="wikitable"		{\|class="wikitable"
	~~!style="text-align: left"\| Drug Interaction:~~
	!style="text-align: left"\| ''Simvastatin:		!style="text-align: left"\| ''Simvastatin:
	\|Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.		\|Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.

2022-08-04T03:56:32Z

Pharmacokinetics

← Older revision		Revision as of 23:56, 3 August 2022
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	{\|class="wikitable"		{\|class="wikitable"
	!style="text-align: left"\| ~~Oral bioavailability~~		!style="text-align: left"\| Drug Interaction:
	\|~~Bromazepam is well absorbed after oral~~ doses.		!style="text-align: left"\| ''Simvastatin:
			\|Co-administration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.
	\|-		\|-
	!style="text-align: left"\| ~~Onset of action~~		!style="text-align: left"\| Contraindication:
	~~\|Bromazepam is well absorbed after oral doses.~~		\|cardiogenic shock, significant aortic stenosis, unstable angina
	~~Peak plasma concentrations are reached between 0.5 and 4 hours of a dose.~~
	\|-
	~~!style="text-align~~: ~~left"\| Metabolism~~
	\|~~Bromazepam is metabolized in the liver~~
	\|-
	~~!style="text-align: left"\| Elimination half-life~~
	~~\|Bromazepam is eliminated in the urine.~~
	~~It has an elimination half-life of about 17 hours (range 11 – 22 hours).~~
	\|}		\|}

2022-08-04T03:54:48Z

Pharmacokinetics

← Older revision		Revision as of 23:54, 3 August 2022
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	'''How long does amlodipine take to work?		'''How long does amlodipine take to work?
	\|-
	Amlodipine starts to work on the day you start taking it, but it may be a couple of weeks before it takes full effect.		Amlodipine starts to work on the day you start taking it, but it may be a couple of weeks before it takes full effect.

2022-08-04T03:54:39Z

Pharmacokinetics

← Older revision		Revision as of 23:54, 3 August 2022
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	'''How long does amlodipine take to work?		'''How long does amlodipine take to work?
			\|-
	Amlodipine starts to work on the day you start taking it, but it may be a couple of weeks before it takes full effect.		Amlodipine starts to work on the day you start taking it, but it may be a couple of weeks before it takes full effect.