Aripiprazole - Revision history

Zeki at 05:17, 19 July 2024

2024-07-19T05:17:41Z

← Older revision		Revision as of 01:17, 19 July 2024
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	'''Aripiprazole (ABILIFY)'''（中文：[[阿立哌唑]]）		'''Aripiprazole (ABILIFY)'''（中文：[[阿立哌唑]]）

	~~==Pronunciation==~~


	==Common Strengths of Aripiprazole Tablet==		==Common Strengths of Aripiprazole Tablet==
	Aripiprazole tablets are available in the following strengths:		Aripiprazole tablets are available in the following strengths:

Zeki: /* Dosages */

2024-07-11T03:35:41Z

Dosages

← Older revision		Revision as of 23:35, 10 July 2024
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	==Dosages==		==Dosages==
	* Schizophrenia (adults): Initial dose 10-15 mg/day, target dose 10-15 mg/day, maximum 30 mg/day		* Schizophrenia (adults): Initial dose 10 - 15 mg/day, target dose 10 - 15 mg/day, maximum 30 mg/day
	* Bipolar disorder (adults): Initial dose 15 mg/day, maximum 30 mg/day		* Bipolar disorder (adults): Initial dose 15 mg/day, maximum 30 mg/day

Zeki: /* Mechanism of Action */

2024-07-11T03:35:21Z

Mechanism of Action

← Older revision		Revision as of 23:35, 10 July 2024
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	==Mechanism of Action==		==Mechanism of Action==
	*Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors.		Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors.

	==Route of Administration==		==Route of Administration==

Zeki at 03:34, 11 July 2024

2024-07-11T03:34:44Z

← Older revision		Revision as of 23:34, 10 July 2024
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	~~[[Category: Drugs]]~~

	[[Category: Drugs]][[Category: Atypical antipsychotic ]]		[[Category: Drugs]][[Category: Atypical antipsychotic ]]

	[[:Category: Antipsychotic Drug \| '''Antipsychotic Drug''']]		[[:Category: Antipsychotic Drug \| '''Antipsychotic Drug''']]

	'''Drug class: [[:Category: Atypical antipsychotic \| Atypical ~~antipsychotic~~ ]]		'''Drug class: [[:Category: Atypical antipsychotic \| Atypical Antipsychotic ]]

	'''Aripiprazole (ABILIFY)'''（中文：[[阿立哌唑]]）		'''Aripiprazole (ABILIFY)'''（中文：[[阿立哌唑]]）

Helen: /* Side Effects */

2024-07-09T02:17:08Z

Side Effects

← Older revision		Revision as of 22:17, 8 July 2024
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	!Adverse reactions		!Adverse reactions
	\|-		\|-
	\| rowspan="9" \| '''Common		\| rowspan="10" \| '''Common
	\| Insomnia: Difficulty sleeping, which often improves over time.		\| Insomnia: Difficulty sleeping, which often improves over time.
	\|-		\|-

Helen at 02:16, 9 July 2024

2024-07-09T02:16:31Z

Show changes

Helen at 02:14, 28 December 2020

2020-12-28T02:14:09Z

← Older revision		Revision as of 22:14, 27 December 2020
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	[[Category: Drugs]][[Category: Antipsychotics, typical; Antipsychotic 2nd Generation]]		[[Category: Drugs]][[Category: Antipsychotics, typical; Antipsychotic 2nd Generation]]
	'''Aripiprazole''' (中文:[[ ]]) is an atypical antipsychotic or 2nd Generation antipsychotic medication. It is mainly used in the treatment of		'''Aripiprazole''' (中文:[[阿立哌唑]]) is an atypical antipsychotic or 2nd Generation antipsychotic medication. It is mainly used in the treatment of
	*Schizophrenia: there is little difference in effectiveness between antipsychotics in prevention of relapse, the specific choice of antipsychotic be chosen based on person’s preference and side-effect profile.		*Schizophrenia: there is little difference in effectiveness between antipsychotics in prevention of relapse, the specific choice of antipsychotic be chosen based on person’s preference and side-effect profile.
	*bipolar disorder: aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder.It is useful for the prevention of manic episodes, but is not useful for bipolar depression.		*bipolar disorder: aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder.It is useful for the prevention of manic episodes, but is not useful for bipolar depression.

Helen at 02:35, 29 October 2020

2020-10-29T02:35:57Z

← Older revision		Revision as of 22:35, 28 October 2020
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	Steady-state plasma concentrations are achieved in about 14 days.		Steady-state plasma concentrations are achieved in about 14 days.
			\|}

			==Drug Management==
			===Monitoring===
			The following populations must be closely monitored after administration of aripiprazole:
			*Elderly persons with susceptibility to drowsiness, confusion, and unsteadiness, which may increase the risk of fall
			*Patients with severe liver failure because of the risk of accumulation.
			*Patients on long-term treatment should receive regular eye examinations.
			*Diabetic patients should get monitoring blood sugar levels during treatment.
			*Changes in mood, the development or worsening depression, and/or any thoughts or behaviour of suicide.
			*Be careful while taking antihistamines (chlorpheniramine), sleeping tablets while taking this medicine. Aripiprazole can increase drowsiness caused by medicines affecting the nervous system.
			*Tell the doctor if notice any of the following:
			-Abnormal movements of the face or tongue
			-Yellowing of the skin and eyes, that is jaundice
			-Muscle twitching
			*Report to the doctor if absence of monthly periods for 6 months or more

			===Drug interaction===
			Aripiprazole is metabolized by multiple pathways involving the CYP2D6 and CYP3A4 enzymes but not CYP1A enzymes. Thus, no dosage adjustment is required for smokers.

			{\| class="wikitable"
			!style="text-align: left"\| Drugs given with aripiprazole
			!style="text-align: left"\| Potential Effect
			\|-
			\|style="text-align: left"\|
			*CNS-depressant drugs including alcohol, hypnotics, anxiolytics, sedative H1 antihistamines, central antihypertensives, baclofen, thalidomide and opioids.
			\|
			Potentiates the sedative effect.
			\|-
			\|style="text-align: left"\|
			*Strong CYP2D6 inhibitors such as qunindine, fluoxetine and paroxetine.
			\|
			May result in higher plasma concentrations of aripiprazole, aripiprazole dose should be reduced to approximately one-half of its prescribed dose.
			\|-
			\|style="text-align: left"\|
			*Strong CYP3A4 inhibitors, such as itraconazole and HIV protease inhibitors
			\|May result in higher plasma concentrations of aripiprazole, so aripiprazole dose should be reduced.
			\|-
			\|style="text-align: left"\|
			*Strong CYP3A4 inducers, such as carbamazepine, rifampicin, phenytoin, phenobarbitone and St John’s Wort.
			\|May lower plasma concentrations of aripiprazole, so should increase aripiprazole dose.
			\|-
			\|style="text-align: left"\|
			*Antiparkinsonian drugs (amantadine, bromocriptine, levodopa, ropinirole)
			\|Antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic.
			\|-
			\|style="text-align: left"\|
			*Drugs that prolong the QT interval e.g. amiodarone, sotalol, quinidine
			*Drugs which induce bradycardia e.g. diltiazem, verapamil
			*Drugs which can cause hypokalaemia such as diuretics e.g. frusemide
			\|An increased risk of ventricular arrhythmias – avoid concomitant use.
	\|}		\|}

			===Caution===
			*In patients with cerebrovascular disease
			*In patients with a history of jaundice or who have blood dyscrasias (perform blood counts if unexplained infection or fever develops)
			*In patients with Parkinson’s disease
			*In patients with epilepsy
			*In patients with myasthenia gravis
			*A susceptibility to angle-closure glaucoma
			*In those with diabetes mellitus
			*In patients with paralytic ileus
			*In patients with prostatic hyperplasia or urinary retention
			*The elderly, especially those with dementia.

			===Contra-indications===
			Use of aripiprazole should be avoided in individuals with:
			*CNS depression
			*Comatose states
			*Phaeochromocytoma

			===Hepatic impairment===
			Use with caution in severe impairment

			===Pregnancy===
			Should be avoided in pregnancy.

			===Breast-feeding===
			Use during breast feeding should be avoided.

			===Driving and skilled tasks===
			Drivers and machine operators should be told about the risk of drowsiness with this medication especially at the start of treatment. Affected patients should not drive or operate machinery.

			==FAQ==
			===How should I take the tablet?===
			You will be prescribed the lowest dose needed to control your symptoms. The tablet should be swallowed whole with a glass of water. It may take 4 to 6 weeks before you get the full benefit of this medication. Do not stop taking this medication without consulting your doctor. You may experience symptoms such as upset stomach, nausea, vomiting, dizziness and shakiness.
			===What should I avoid while taking?===
			Avoid drinking alcohol while taking aripiprazole because it may enhance the side effects of sedation.

			Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
			===What happen if I overdose?===
			A : Contact your primary care doctor.
			If emergency situation, call 999
			===What happen if I miss a dose?===
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the
			regular time. Do not double the dose to catch up.

Helen at 02:23, 29 October 2020

2020-10-29T02:23:08Z

← Older revision		Revision as of 22:23, 28 October 2020
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	It is recommended that gradual withdrawal when discontinuing antipsychotics. Symptoms of withdrawal commonly include nausea, vomiting and loss of appetite. Symptoms generally resolve after a short period of time.		It is recommended that gradual withdrawal when discontinuing antipsychotics. Symptoms of withdrawal commonly include nausea, vomiting and loss of appetite. Symptoms generally resolve after a short period of time.

			==Pharmacokinetics==
			{\|class="wikitable"
			!style="text-align: left"\| Oral bioavailability
			\|It is readily absorbed after oral doses.
			\|-
			!style="text-align: left"\| Onset of action
			\|Peak plasma concentrations are achieved 3 – 5 hours after an oral dose.
			\|-
			!style="text-align: left"\| Metabolism
			\|It is metabolized in the liver, principally by the enzymes CYP2D6 and CYP3A4
			\|-
			!style="text-align: left"\| Elimination half-life
			\|
			It is eliminated via urine and faeces.

			The elimination half-life is approximately 75 hours.

			Steady-state plasma concentrations are achieved in about 14 days.

			\|}

Helen at 02:21, 29 October 2020

2020-10-29T02:21:42Z

← Older revision		Revision as of 22:21, 28 October 2020
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	\|P1S1S3		\|P1S1S3
	\|}		\|}

			==Mechanism of Action==
			Aripiprazole is a dopamine D2 partial agonist. It is also a partial activator of serotonin 5-HT1A receptors.
			Aripiprazole acts by modulating neurotransmission overactivity of dopamine, which is thought to mitigate schizophrenia symptoms.

			==Dosage==
			{\| class="wikitable"
			!style="text-align: left"\| Indication
			!style="text-align: left"\| Dose
			\|-
			!style="text-align: left"\| Schizophrenia
			\|By ''mouth
			ADULT:
			*10 – 15 mg once daily,
			*Maximum 30 mg once daily
			\|-
			!style="text-align: left"\| Treatment and recurrence prevention of mania
			\|By ''mouth
			ADULT:
			*15 mg once daily
			*Maximum 30 mg once daily
			\|-
			!style="text-align: left"\| Adjunct treatment of major depressive disorder
			\|By ''mouth
			ADULT:
			*Initially 2- 5 mg once daily,
			*Increased to 5 – 10 mg once daily
			*Maximum 15 mg once daily
			\|}

			How long does it take for Amisulpride to work?
			The patient may start to feel better in a few days but it can take as long as 4 to 6 weeks before the full effects of this medication is noticed.

			==Side Effects==
			All side-effects are listed by system organ and frequency.
			*Common ( ≥ 1/100 to < 1/10)
			*Uncommon (≥ 1/1000 to < 1/100)

			{\| class = "wikitable"
			!style="text-align: left"\| Endocrine disorders
			\|
			Uncommon: hyperprolactinaemia (elevated levels of the hormone prolactin, which for females may result in
			*Galactorrhea (unwanted breast milk)
			*amornorrhea (missed/stopped periods),
			For males it may result in
			*decreased sexual ability, or
			*gynecomastia (enlarged breast)
			\|-
			!style="text-align: left"\| Muscle/Nervous system disorders:
			\|
			Common:
			*Extrapyramidal symptoms (EPS)
			-Tremor
			-Akathisia
			-Parkinsonism
			*Anticholinergic side-effects such as:
			-Dry mouth
			-Constipation
			-Blurred vision
			*headache
			*sedation
			*somnolence
			*dizziness
			*salivary hypersecretion
			Uncommon: tardive dyskinesia and seizures
			Not known: Neuroleptic malignant syndrome
			\|-
			!style="text-align: left"\| Psychiatric disorders
			\|
			Common:
			*Insomnia
			*Anxiety
			*Restlessness
			Uncommon:
			*Depression
			*hypersexuality
			\|-
			!style="text-align: left"\| Metabolism disorders
			\|
			Common:
			*diabetes mellitus
			*weight gain
			Uncommon:
			*Hyponatraemia
			*Anorexia
			\|-
			!style="text-align: left"\| Cardiac disorders
			\|
			Uncommon:
			*tachycardia
			*orthostatic hypotension
			\|}

			Pathological gambling, compulsive shopping and binge eating can occur in patients treated with aripiprazole.

			It is not recommended for older people with dementia-related psychosis due to an increased risk of death.
			Discontinuation

			It is recommended that gradual withdrawal when discontinuing antipsychotics. Symptoms of withdrawal commonly include nausea, vomiting and loss of appetite. Symptoms generally resolve after a short period of time.