Betamethasone - Revision history

Helen: /* Drug Management */

2020-10-14T02:38:23Z

Drug Management

← Older revision		Revision as of 22:38, 13 October 2020
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	*patients with active or doubtfully quiescent tuberculosis		*patients with active or doubtfully quiescent tuberculosis
	*concurrent treatment live virus vaccines for at least 3 months afterwards		*concurrent treatment live virus vaccines for at least 3 months afterwards


	===Hepatic impairment===		===Hepatic impairment===

Helen: /* Drug Management */

2020-10-14T02:38:05Z

Drug Management

← Older revision		Revision as of 22:38, 13 October 2020
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	\|}		\|}

	~~'''~~Caution:		===Caution===
	*Children and adolescents (growth restriction possibly irreversible)		*Children and adolescents (growth restriction possibly irreversible)
	*Osteoporosis (post-menopausal women at special risk)		*Osteoporosis (post-menopausal women at special risk)
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	~~'''~~Hepatic impairment		===Hepatic impairment===
	When steroids are administered orally or parenterally, the plasma-drug concentration may be increased in patients with hepatic impairment. The patient should be monitored closely.		When steroids are administered orally or parenterally, the plasma-drug concentration may be increased in patients with hepatic impairment. The patient should be monitored closely.

	~~'''~~Renal impairment		===Renal impairment===
	Should be used with caution in patients with renal impairment.		Should be used with caution in patients with renal impairment.

	~~'''~~Pregnancy		===Pregnancy===
	Betamethasone should only be used in pregnant women when benefits outweigh the risks.		Betamethasone should only be used in pregnant women when benefits outweigh the risks.
	*No convincing evidence that systemic steroids increase the incidence of congenital abnormalities such as cleft palate or lip.		*No convincing evidence that systemic steroids increase the incidence of congenital abnormalities such as cleft palate or lip.
	*Prolonged use increases the risk of intra-uterine growth; but no evidence of intra-uterine growth restriction following short-term treatment.		*Prolonged use increases the risk of intra-uterine growth; but no evidence of intra-uterine growth restriction following short-term treatment.

	~~'''~~Note		===Note===

	{\| class = "wikitable"		{\| class = "wikitable"
	!style="text-align: left"\| Prolonged use of steroid		!style="text-align: left"\| Prolonged use of steroid
	!~~'''~~Recommendation		!style="text-align: left"\| Recommendation
	\|-		\|-
	\|~~'''~~Immunosuppression		\|style="text-align: left"\| Immunosuppression
	Prolonged use can increase susceptibility to infection		Prolonged use can increase susceptibility to infection

	\|Avoid contact with people who have chickenpox, shingles, or measles.		\|Avoid contact with people who have chickenpox, shingles, or measles.
	\|-		\|-
	\|~~'''~~Adrenal suppression		\|style="text-align: left"\| Adrenal suppression
	Steroid suppresses the endogenous secretion of corticotropin by the anterior pituitary, resulting the adrenal cortex becomes atrophied.		Steroid suppresses the endogenous secretion of corticotropin by the anterior pituitary, resulting the adrenal cortex becomes atrophied.
	If given for more than 3 weeks, treatment must not be stopped gradually.		If given for more than 3 weeks, treatment must not be stopped gradually.

Helen: /* Drug Management */

2020-10-14T02:36:47Z

Drug Management

← Older revision		Revision as of 22:36, 13 October 2020
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	==Drug Management==		==Drug Management==

	~~'''~~Monitoring:		===Monitoring===
	*Elderly (close supervision required particularly on long-term treatment)		*Elderly (close supervision required particularly on long-term treatment)
	*Frequent monitoring required if history of tuberculosis (or X-ray changes)		*Frequent monitoring required if history of tuberculosis (or X-ray changes)

Helen: /* Drug Management */

2020-10-14T02:36:37Z

Drug Management

← Older revision		Revision as of 22:36, 13 October 2020
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	*Height should be monitored in children receiving prolonged therapy with inhaled or nasal steroid.		*Height should be monitored in children receiving prolonged therapy with inhaled or nasal steroid.

	~~'''~~Drug interaction:		===Drug interaction===
	Interactions do not generally apply to steroid used for topical action including inhalation, unless specified.		Interactions do not generally apply to steroid used for topical action including inhalation, unless specified.

Helen: /* Pharmacokinetics */

2020-10-14T02:36:23Z

Pharmacokinetics

← Older revision		Revision as of 22:36, 13 October 2020
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	==Pharmacokinetics==		==Pharmacokinetics==

	Betamethasone is readily absorbed from the gastrointestinal tract~~. It is also absorbed when given locally or use rectally as an enema.~~		Betamethasone is readily absorbed from the gastrointestinal tract.
	~~Steroid is rapidly distributed to all body tissues. They cross the placenta and may distributed in small amounts into breast milk~~.

			It is also absorbed when given locally or use rectally as an enema.

			Steroid is rapidly distributed to all body tissues.

			They cross the placenta and may distributed in small amounts into breast milk.

	==Drug Management==		==Drug Management==

Helen: /* Short-term use */

2020-10-14T02:36:05Z

Short-term use

← Older revision		Revision as of 22:36, 13 October 2020
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	===Short-term use===		===Short-term use===
	include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.		include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.

	===Long-term steroid use can lead to:===		===Long-term steroid use can lead to:===

Helen: /* Long-term steroid use can lead to: */

2020-10-14T02:35:57Z

Long-term steroid use can lead to:

← Older revision		Revision as of 22:35, 13 October 2020
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	\|		\|
	\|-		\|-
	!\|Steroid-induced diabetes		!style="text-align: left"\| Steroid-induced diabetes
	\|		\|
	\|-		\|-
	!\|Osteoporosis, muscle wasting and weakness		!style="text-align: left"\| Osteoporosis, muscle wasting and weakness
	\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae		\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae
	\|-		\|-
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	\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia		\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia
	\|-		\|-
	!Neuropsychiatric side effects		!style="text-align: left"\| Neuropsychiatric side effects
	\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes		\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes
	\|-		\|-
	!Dermatological effects		!style="text-align: left"\| Dermatological effects
	\|easy bruising, impaired wound healing, and thinning of skin		\|easy bruising, impaired wound healing, and thinning of skin
	\|-		\|-
	!Ophthalmic effects		!style="text-align: left"\| Ophthalmic effects
	\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease		\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease

	\|}		\|}

Helen: /* Long-term steroid use */

2020-10-14T02:35:28Z

Long-term steroid use

← Older revision		Revision as of 22:35, 13 October 2020
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	include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.		include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.

	===Long-term steroid use~~===~~		===Long-term steroid use can lead to:===
	can lead to:

	{\| class = "wikitable"		{\| class = "wikitable"

Helen: /* Side Effects */

2020-10-14T02:35:11Z

Side Effects

← Older revision		Revision as of 22:35, 13 October 2020
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	==Side Effects==		==Side Effects==

	Short-term use include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.		===Short-term use===
			include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.

	Long-term steroid use can lead to:		===Long-term steroid use===
			can lead to:

	{\| class = "wikitable"		{\| class = "wikitable"
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	Side-effects can be minimized by using lowest effective dose for minimum period possible.		Side-effects can be minimized by using lowest effective dose for minimum period possible.


	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* Dosage */

2020-10-14T02:33:40Z

Dosage

← Older revision		Revision as of 22:33, 13 October 2020
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	*12 years and older: adult doses		*12 years and older: adult doses
	\|-		\|-
	~~\|Doses repeated up to 4 times in 24 hours according to response~~
	\|}		\|}

			Doses repeated up to 4 times in 24 hours according to response

	==Side Effects==		==Side Effects==