Helen at 09:11, 8 July 2024

2024-07-08T09:11:24Z

← Older revision		Revision as of 05:11, 8 July 2024
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	==Drug Trade Names of ~~BrexpiprazoleBrexpiprazole~~ Tablet==		==Drug Trade Names of Brexpiprazole Tablet==
	Rexulti is the trade name for Brexpiprazole:		Rexulti is the trade name for Brexpiprazole:

Helen: Created page with "Category: DrugsCategory: Atypical antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Atypical antipsychotic | A..."

2024-07-08T08:58:02Z

Created page with "Category: Drugs Category: Atypical antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Atypical antipsychotic | A..."

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[[Category: Drugs]][[Category: Atypical antipsychotic ]]

[[:Category: Antipsychotic Drug | '''Antipsychotic Drug''']]

'''Drug class: [[:Category: Atypical antipsychotic | Atypical antipsychotic ]]

'''Brexpiprazole (Rexulti)'''（中文：[[銳思定]]）

==Common Strengths of Brexpiprazole Tablet==
Brexpiprazole tablets are available in the following strengths:
* 0.25 mg

* 0.5 mg

* 1 mg

* 2 mg

* 3 mg

* 4 mg

==Drug Trade Names of BrexpiprazoleBrexpiprazole Tablet==
Rexulti is the trade name for Brexpiprazole:

==Drug Usage==
Brexpiprazole is used for:
* Treatment of schizophrenia
* Adjunctive treatment of major depressive disorder (MDD)
* Treatment of agitation associated with dementia due to Alzheimer's disease

==Mechanism of Action==
Brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors. It modulates dopaminergic and

serotonergic activity to improve symptoms of schizophrenia and depression

==Route of Administration==
Brexpiprazole is administered orally in the form of tablets or liquid solution.

==Dosages==
* Schizophrenia (Adults): Initial dose of 1 mg once daily, titrated to 2 mg on Day 5 to 7, and up to 4 mg by Day 8. Target dose: 2 to 4 mg daily. Maximum dose: 4 mg/day.

* Depression (Adults): Initial dose of 0.5 mg or 1 mg once daily, titrated to 2 mg daily. Maximum dose: 3 mg/day.
* Pediatric Schizophrenia (13-17 years): Initial dose of 0.5 mg once daily, titrated to 1 mg on Day 5 to 7, and up to 2 mg by Day 8. Maximum dose: 4 mg/day.

For patients with moderate to severe renal impairment, the dosage of brexpiprazole should be reduced to a maximum of 3 mg per day for schizophrenia and 2 mg per day for MDD.

No adjustment is needed for mild renal impairment.

==Side Effects==
{| class="wikitable"
!style="text-align: left"| Frequency
!Adverse reactions
|-
| rowspan="12" | '''Common
| Weight gain
|-
| Akathisia (feeling of restlessness, constant urge to move)
|-
| Headache
|-
| Drowsiness/sleepiness
|-
| Dizziness
|-
| Nausea
|-
| Constipation
|-
| Indigestion/heartburn
|-
| Increased appetite
|-
| Fatigue/tiredness
|-
| Tremor
|-
| Stuffy or runny nose
|-
| rowspan="13" | '''Uncommon
| Neuroleptic malignant syndrome (high fever, muscle stiffness, confusion)
|-
| Tardive dyskinesia (uncontrolled muscle movements)
|-
| High blood sugar/diabetes
|-
| Orthostatic hypotension (dizziness when standing up)
|-
| Seizures
|-
| Low white blood cell count
|-
| Difficulty swallowing
|-
| Suicidal thoughts or behaviors (especially in young adults)
|-
| Compulsive behaviors (gambling, sexual urges, binge eating)
|-
| Cognitive impairment
|-
| Impaired body temperature regulation
|-
| Stroke in elderly patients with dementia-related psychosis
|-
| Allergic reactions (rash, itching, difficulty breathing)
|}

==Pharmacokinetics==
*Absorption
**Peak plasma concentration within 4 hours.
*Metabolism
**Primarily metabolized by CYP3A4 and CYP2D6.
*Excretion
**25% in urine and 46% in feces. Terminal elimination half-life is approximately 91 hours.

Initial effects: Some patients may begin to see improvements within 1 to 2 weeks of starting treatment.

Full Therapeutic Effects: The best results are typically observed after 4 to 6 weeks for schizophrenia and major depressive disorder (MDD) For agitation associated with

dementia due to Alzheimer's disease, significant results may be seen in about 12 weeks.

==Drug Precautions==
'''Increased risk in elderly patients

*Should not be used to treat dementia-related psychosis in older adults due to increased risk of stroke and death
*May cause drowsiness, dizziness, and difficulty swallowing in elderly patients, increasing the risk of falls and choking

'''Suicidal thoughts in young people

*May increase the risk of suicidal thoughts in young people under 24 years old, especially in the first few months of treatment or with dose changes
*Close monitoring is required for children/teens taking aripiprazole

'''Use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold.

'''Dysphagia

*Esophageal dysmotility and aspiration associated with antipsychotic drug use
*Use cautiously in patients at risk for aspiration pneumonia

'''Monitoring Requirements
*Regular monitoring of blood sugar levels, weight, and signs of extrapyramidal symptoms
*Perform complete blood count (CBC) in patients with pre-existing low white blood cell count (WBC) or history of drug-induced leukopenia/neutropenia
*Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope

'''Drug Interactions

*Avoid strong CYP3A4 inducers and inhibitors

==FAQ==
'''How Should I Take the Tablet?
* Take brexpiprazole once daily with or without food, at the same time each day.

''What should I avoid while taking brexpiprazole?
*Avoid alcohol, and activities requiring alertness until you know how the medication affects you. Avoid overheating and dehydration

'''What Happens if I Miss a Dose?
*Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Brexpiprazole - Revision history

Helen at 09:11, 8 July 2024

Helen: Created page with "Category: DrugsCategory: Atypical antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Atypical antipsychotic | A..."