Bromocriptine - Revision history

Zeki at 07:21, 21 October 2024

2024-10-21T07:21:31Z

← Older revision		Revision as of 03:21, 21 October 2024
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	'''Drug class: [[:Category: Dopamine D2 receptor agonist \| Dopamine D2 Receptor Agonist]]		'''Drug class: [[:Category: Dopamine D2 receptor agonist \| Dopamine D2 Receptor Agonist]]

	'''Bromocriptine (PARLODEL)		'''Bromocriptine (PARLODEL)（中文：[[溴隱亭]]）
	==Pronunciation==		==Pronunciation==
	===Bromocriptine 2.5mg===		===Bromocriptine 2.5mg===

Zeki at 07:11, 21 October 2024

2024-10-21T07:11:53Z

← Older revision		Revision as of 03:11, 21 October 2024
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	===Bromocriptine 2.5mg===		===Bromocriptine 2.5mg===
	[[File:Bromocriptine 2.5mg.mp3]]		[[File:Bromocriptine 2.5mg.mp3]]

			==Common Strengths of Bromocriptine==
			*Tablet: 2.5 mg

			==Drug Trade Names==
			*Parlodel

			==Drug Usage==
			Bromocriptine is indicated for:
			*Hyperprolactinemia: Conditions leading to excessive prolactin levels.
			*Parkinson's Disease: To manage symptoms like stiffness and tremors.
			*Acromegaly: To contorl growth hormone secretion.

			==Mechanism of Action==
			Bromocriptine acts as an agonist on dopamine D2 receptors, inhibiting prolactin secretion from the pituitary gland and alleviating symptoms associated with conditions like hyperprolactinemia and Parkinson's disease.

			==Route of Administration==
			Oral

			==Dosages==
			*Initial: 1.25-2.5 mg once daily.
			*Maintenance: 5-15 mg/day, with some cases requiring up to 30 mg/day.

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="3" \| '''Common Side Effects
			\| Dizziness
			\|-
			\| Nausea
			\|-
			\| Headaches
			\|-
			\| rowspan="3" \| '''Serious Side Effects
			\| Hallucinations
			\|-
			\| Severe hypotension
			\|-
			\| Pulmonary fibrosis
			\|}

			==Pharmacokinetics==
			*Bioavailability: Approximately 28% after oral administration.
			*Half-life: 12-14 hours.
			*Onset of Action: Varies; generally within hours for most effects, but full therapeutic effects may take longer.

			==Drug Precautions==
			'''Pregnancy

			Bromocriptine may be acceptable during pregnancy, but caution is warranted, especially in women with high blood pressure.

			'''Breastfeeding

			Not recommended as it can inhibit lactation.

			'''Children and Elderly

			Dosage adjustments are often necessary; pediatric use is typically limited to ages 11-15 years.

			'''Drug Monitoring Items
			*Blood Pressure Monitoring: Patients should have their blood pressure monitored regularly. Orthostatic hypotension can occur, leading to dizziness or syncope.
			*Liver Function Tests: Regular liver function test should be conducted to monitor for elevated liver enzymes.
			*Pregnancy Testing: Women of childbearing age should undergo pregnancy testing if amenorrhea occurs while on bromocriptine, as the medication can suppress prolactin levels necessary for normal pregnancy.
			*Cardiac Monitoring: A cardiovascular assessment is advised before starting bromocriptine, especially in patients with a history of cardiovascular disease. Close monitoring is necessary throughout treatment due to potential cardiac side effects like myocardial toxicity.
			*Regular Eye Examinations: Patinets may require periodic eye exams if they are at risk for visual disturbances related to bromocriptine use.
			*Monitoring for Impulse Control Disorders: Patients should be assessed for behavioral changes or impulse control issues, which can occur with dopamine agonists like bromocriptine.

			'''Drug Interactions

			Bromociptine may interact with:
			*Dopamine Antagonists
			**Antipsychotics (e.g. clozapine, olanzapine): These can reduce the effectiveness of bromocriptine due to their dopamine-blocking properties. Concurrent use is not recommended.
			*Sympathomimetics
			**Amphetamines and other sympathomimetic agents: Co-administration can lead to hypertension and tachycardia, particularly in postpartum women.
			*Selective Serotonin Reuptake Inhibitors (SSRIs)
			**SSRIs may increase the risk of serotonin syndrome when combined with bromocriptine.
			*Triptans (e.g. sumatriptan)
			**The combination can also lead to serotonin syndrome and is generally contraindicated.
			*Benzodiazepines
			**Combining bromocriptine with benzodiazepines may increase the risk of CNS depression.
			*Metformin
			**There may be an increased risk of hypoglycemia when bromocriptine is used alongside metformin.
			*CYP3A4 inhibitors (e.g. erythromycin) which may increase bromocriptine levels.

			==FAQ==
			'''How Should I Take the Tablet?

			Take bromocriptine orally with food to minimize gastrointestinal side effects.

			'''What Should I Avoid While Taking?

			Avoid activities that require alertness until you know how bromocriptine affects you; also, avoid alcohol and other CNS depressants.

			'''What Happens if I Miss a Dose?

			If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double up on doses.

Zeki at 06:25, 21 October 2024

2024-10-21T06:25:19Z

← Older revision		Revision as of 02:25, 21 October 2024
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	[[Category: Drugs]][[Category: Dopamine receptor agonist]]		[[Category: Drugs]][[Category: Dopamine D2 receptor agonist]]

	[[:Category: Antiparkinsonian Drug \| '''Antiparkinsonian Drug''']]		[[:Category: Antiparkinsonian Drug \| '''Antiparkinsonian Drug''']]

	'''Drug class: [[:Category: Dopamine receptor agonist \| Dopamine Receptor Agonist]]		'''Drug class: [[:Category: Dopamine D2 receptor agonist \| Dopamine D2 Receptor Agonist]]

	'''Bromocriptine (PARLODEL)		'''Bromocriptine (PARLODEL)

Zeki at 06:33, 5 September 2024

2024-09-05T06:33:40Z

← Older revision		Revision as of 02:33, 5 September 2024
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	[[Category: Drugs]][[Category: Dopamine receptor agonist]]		[[Category: Drugs]][[Category: Dopamine receptor agonist]]

			[[:Category: Antiparkinsonian Drug \| '''Antiparkinsonian Drug''']]

			'''Drug class: [[:Category: Dopamine receptor agonist \| Dopamine Receptor Agonist]]

			'''Bromocriptine (PARLODEL)
	==Pronunciation==		==Pronunciation==
	===Bromocriptine 2.5mg===		===Bromocriptine 2.5mg===
	[[File:Bromocriptine 2.5mg.mp3]]		[[File:Bromocriptine 2.5mg.mp3]]

Zeki at 07:39, 25 July 2024

2024-07-25T07:39:11Z

← Older revision		Revision as of 03:39, 25 July 2024
Line 1:		Line 1:
	[[Category: Drugs]]		[[Category: Drugs]][[Category: Dopamine receptor agonist]]
	==Pronunciation==		==Pronunciation==
	===Bromocriptine 2.5mg===		===Bromocriptine 2.5mg===
	[[File:Bromocriptine 2.5mg.mp3]]		[[File:Bromocriptine 2.5mg.mp3]]

Colin Bot: Populate pages with audio

2020-09-08T09:37:19Z

Populate pages with audio

← Older revision		Revision as of 05:37, 8 September 2020
Line 1:		Line 1:
	[[Category: Drugs]]		[[Category: Drugs]]
	==Pronunciation==		==Pronunciation==
	===Bromocriptine 2.5mg.===		===Bromocriptine 2.5mg===
	[[File:Bromocriptine 2.5mg.mp3]]		[[File:Bromocriptine 2.5mg.mp3]]

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2020-09-08T09:24:18Z

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[[Category: Drugs]]
==Pronunciation==
===Bromocriptine 2.5mg.===
[[File:Bromocriptine 2.5mg.mp3]]