Bupropion - Revision history

Zeki at 07:47, 15 August 2024

2024-08-15T07:47:52Z

← Older revision		Revision as of 03:47, 15 August 2024
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	\| Manic episodes: Symptoms include excessively high energy, severe trouble sleeping, racing thoughts, reckless behavior, and unusually grand ideas.		\| Manic episodes: Symptoms include excessively high energy, severe trouble sleeping, racing thoughts, reckless behavior, and unusually grand ideas.
	\|}		\|}

			==Pharmacokinetics==
			*Extensively metabolized by CYP2B6 in the liver
			*Elimination half-life: approximately 10 - 20 hours

			The full therapeutic effects of bupropion can take 4 to 6 weeks to manifest.

			Bupropion's pharmacokinetic profile is characterized by rapid absorption, extensive metabolism, and a significant presence of active metabolites.

			==Drug Precautions==
			'''Pregnancy

			Use with caution; potential risks to the fetus

			'''Breastfeeding

			Use with caution; bupropion is ecreted in breast milk

			'''Children and Elderly
			*Not recommended for children under 18 for depression
			*Elderly may require lower doses due to decreased clearance

			'''Monitoring Requirements
			*Blood pressure
			*Signs of suicidal thoughts or behaviors
			*Seizure risk
			*Liver function

			'''Drug Interaction
			*Major Drug Interactions
			**Bupropion is primarily metabolized by CYP2B6, so inhibitors or inducers of this enzyme can significantly affect bupropion levels. Examples of CYP2B6 inhibitors include ticlopidine and clopidogrel.
			**Bupropion is a moderate inhibitor of CYP2D6, so it can increase levels of medications metabolized by this enzyme like venlafaxine, desipramine, and metoprolol.
			**Combining bupropion with other antidepressants like SSRIs like fluoxetine (Prozac) and sertraline (Zoloft), venlafaxine or duloxetine may increase the risk of serotonin syndrome, especially in poor CYP2D6 metabolizers.
			**Bupropion can lower the seizure threshold, so it should be avoided in patients with seizure disorders or eating disorders like bulimia or anorexia that increase seizure risk.
			**Drinking alcohol while taking bupropion may increase the risk of seizures. Alcohol should be limited or avoided.
			**Antipsychotics: Drugs like thioridazine can interact with bupropion, increasing the risk of side effects such as seizures and cardiovascular issues.
			**Tamoxifen: Bupropion can reduce the effectiveness of tamoxifen, a medication used in breast cancer treatment.

			==FAQ==
			'''How Should I Take the Tablet?

			Take the tablet whole with or without food. Do not crush, chew, or split extended-release tablets

			'''What Should I Avoid While Taking?

			Avoid alcohol consumption and operating heavy machinery until you know how bupropion affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Zeki at 07:09, 15 August 2024

2024-08-15T07:09:12Z

← Older revision		Revision as of 03:09, 15 August 2024
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	==Side Effects==		==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="13" \| '''Common
			\| '''These side effects are generally not severe and may diminish as your body adjusts to the medication.'''
			\|-
			\| Dry mouth: Chew sugar-free gum or sweets.
			\|-
			\| Constipation: Increase fiber intake and drink plenty of water
			\|-
			\| Dizziness: Change sitting or standing position slowly
			\|-
			\| Nausea: Stick to simple meals and avoid rich or spicy foods
			\|-
			\| Increased sweating: Wear loose clothing and use a fan if needed
			\|-
			\| Tremors or shaking
			\|-
			\| Insomnia: Take in the morning
			\|-
			\| Blurred vision
			\|-
			\| Ringing in the ears (tinnitus)
			\|-
			\| Agitation
			\|-
			\| Restlessness
			\|-
			\| Anxiety
			\|-
			\| rowspan="8" \| '''Serious
			\| '''Serious side effect of bupropion require immediate medical attention. These include:'''
			\|-
			\| Seizures: Bupropion can lower the seizure threshold, especially at higher doses.
			\|-
			\| Severe allergic reaction: Symptoms can include hives, itching, fever, swollen glands, difficulty breathing, and swelling of the face or throat.
			\|-
			\| Mental health effects: These can include new or worsening depression, suicidal thoughts or behaviors, panic attacks, agitation, aggression, hostility, and other unusual changes in behavior or mood.
			\|-
			\| Cardiovascular issues: Fast or irregular heartbeats, chest pain, and high blood pressure.
			\|-
			\| Eye problems: Pain, swelling, redness, or vision changes such as blurred or double vision.
			\|-
			\| Severe skin reactions: Rash, blisters, peeling skin, and other severe skin reactions.
			\|-
			\| Manic episodes: Symptoms include excessively high energy, severe trouble sleeping, racing thoughts, reckless behavior, and unusually grand ideas.
			\|}

Zeki at 06:42, 15 August 2024

2024-08-15T06:42:22Z

← Older revision		Revision as of 02:42, 15 August 2024
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	==Drug Usage==		==Drug Usage==
			*Major depressive disorder (MDD)
			*Seasonal affective disorder (SAD): Bupropion is used to manage seasonal patterns of depression.
			*Smoking cessation: Under the brand name Zyban, it helps reduce nicotine cravings and withdrawal symptoms.

			==Mechanism of Action==
			Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI).
			It works by inhibiting the reuptake of norepinephrine and dopamine, two neurotransmitters involved in mood regulation and reward pathways. By preventing their reabsorption, bupropion increases the levels of these neurotransmitters in the brain, which can help alleviate symptoms of depression and aid in smoking cessation.

			==Route of Administration==
			Oral

			==Dosages==
			Major depressive disorder (MDD):
			*Immediate-release: 100 mg twice daily, up to 450 mg/day
			*Sustained-release: 150 mg twice daily, up to 400 mg/day
			*Extended-release: 150 - 300 mg once daily, up to 450 mg/day

			Renal dose based on eGFR:
			*eGFR 30 - 89 mL/min: Reduce dose by 25 - 50%
			*eGFR <30 mL/min: Reduce dose by 50% or more

			==Side Effects==

Zeki at 05:55, 15 August 2024

2024-08-15T05:55:31Z

← Older revision		Revision as of 01:55, 15 August 2024
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	'''Bupropion (WELLBUTRIN)'''（中文：[[安非他酮]]）		'''Bupropion (WELLBUTRIN)'''（中文：[[安非他酮]]）
			==Common Strengths of Bupropion==
			Bupropion are available in the following strengths:
			*Immediate-release: 75 mg, 100 mg
			*Sustained-release (SR): 100 mg, 150 mg, 200 mg
			*Extended-release (XL): 150 mg, 300 mg, 450 mg

			==Drug Trade Names of Bupropion==
			*Wellbutrin
			*Wellbutrin SR
			*Wellbutrin XL
			*Zyban

			==Drug Usage==

Zeki: Created page with "Category: DrugsCategory: Atypical antidepressants '''Antidepressant Drug''' '''Drug class: :Category: Atypical antidepressants..."

2024-08-15T03:38:41Z

Created page with "Category: Drugs Category: Atypical antidepressants '''Antidepressant Drug''' '''Drug class: :Category: Atypical antidepressants..."

New page

[[Category: Drugs]][[Category: Atypical antidepressants]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Atypical antidepressants | Atypical Antidepressants]]

'''Bupropion (WELLBUTRIN)'''（中文：[[安非他酮]]）