Cabergoline - Revision history

Zeki at 03:51, 4 November 2024

2024-11-04T03:51:05Z

← Older revision		Revision as of 23:51, 3 November 2024
Line 57:		Line 57:

	Use in children requires careful consideration and monitoring. In elderly patients, increased sensitivity to side effects may occur; dosage adjustments may be necessary.		Use in children requires careful consideration and monitoring. In elderly patients, increased sensitivity to side effects may occur; dosage adjustments may be necessary.

			'''Drug Monitoring Items

			Regular monitoring of:
			*Prolactin levels
			*Cardiac function (echocardiograms) to assess for valvular disease. Discontinuation is advised if new valvular regurgitation or thickening is detected.
			*Blood pressure due to risk of orthostatic hypotension.
			*Impulse Control Issues: Some patients may experience increased sexual urges or compulsive behaviors. Monitoring and possible dose adjustment are recommended if these symptoms occur.

			'''Drug Interactions
			*Dopamine Antagonists: Drugs like metoclopramide, phenothiazines, and butyrophenones may reduce the prolactin-lowering effect of cabergoline and should not be used concurrently.
			*Anti-depressants such as
			**Cymbalta (duloxetine)
			**Lexapro (escitalopram)
			**Prozac (fluoxetine)
			**Zoloft (sertraline)
			*Macrolide Antibiotics: Co-administration with macrolides (e.g. erythromycin) can increase the systemic bioavailability of cabergoline, thus increasing the risk of side effects.

			==FAQ==
			'''How Should I Take the Tablet?

			Take cabergoline by mouth with or without food as directed by your healthcare provider.

			'''What Should I Avoid While Taking?

			Avoid activities requiring mental alertness until you know how cabergoline affects you; also limit alcohol consumption due to potential interactions.

			'''What Happens if I Miss a Dose?

			If you miss a dose, take it as soon as you remember unless it s almost time for your next dose; do not double up on doses.

Zeki at 03:34, 4 November 2024

2024-11-04T03:34:18Z

← Older revision		Revision as of 23:34, 3 November 2024
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	'''Cabergoline (DOSTINEX)'''（中文：[[卡麥角林]]）		'''Cabergoline (DOSTINEX)'''（中文：[[卡麥角林]]）
			==Common Strengths==
			*0.5 mg

			==Drug Trade Names==
			*Dostinex

			==Drug Usage==
			Cabergoline is utilized for:
			*Treating hyperprolactinemia (high prolactin levels).
			*Managing prolactinomas (tumors that produce prolactin).
			*Adjunct therapy in Parkinson's disease.

			==Mechanism of Action==
			Cabergoline works by stimulating dopamine D2 receptors, which inhibits the secretion of prolactin from the pituitary gland. This action helps normalize prolactin levels and can improve symptoms related to hyperprolactinemia and certain cases of Parkinson's disease.

			==Route of Administration==
			Cabergoline is administered '''orally''' in tablet form.

			==Dosages==
			*Initial dose: 0.25 mg twice weekly
			*Maximum dose: 1 mg twice weekly

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| '''Common Side Effects
			\| Nausea, vomiting, dizziness, fatigue, and abdominal pain.
			\|-
			\| '''Serious Side Effects
			\| Cardiac valvopathy, pulmonary fibrosis, severe hypotension, and compulsive behaviors (e.g. gambling)
			\|}

			==Pharmacokinetics==
			*Onset of Action: Typically, within a few hours after administration.
			*Duration of Action: Long-lasting effects, allowing for dosing twice weekly.
			*Half-life: Approximately 63 to 109 hours after oral administration.

			==Drug Precautions==
			'''Pregnancy

			The safety of cabergoline during pregnancy is not well established.

			'''Breastfeeding

			Cabergoline is not recommended during breastfeeding due to its potential effects on milk production.

			'''Children and Elderly

			Use in children requires careful consideration and monitoring. In elderly patients, increased sensitivity to side effects may occur; dosage adjustments may be necessary.

Zeki: Created page with "Category: DrugsCategory: Dopaminergic Antiparkinsonian agent '''Antiparkinsonian Drug''' '''Drug class: :Category: Dopaminer..."

2024-11-04T02:09:43Z

Created page with "Category: Drugs Category: Dopaminergic Antiparkinsonian agent '''Antiparkinsonian Drug''' '''Drug class: :Category: Dopaminer..."

New page

[[Category: Drugs]][[Category: Dopaminergic Antiparkinsonian agent]]

[[:Category: Antiparkinsonian Drug | '''Antiparkinsonian Drug''']]

'''Drug class: [[:Category: Dopaminergic Antiparkinsonian agent | Dopaminergic Antiparkinsonian Agent]]'''; [[:Category: Prolactin inhibitor | Prolactin Inhibitor]]

'''Cabergoline (DOSTINEX)'''（中文：[[卡麥角林]]）