Zeki at 06:06, 30 September 2024

2024-09-30T06:06:15Z

← Older revision		Revision as of 02:06, 30 September 2024
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	'''Cefalexin (KEFLEX)'''（中文：[[頭孢氨芐]]）		'''Cefalexin (KEFLEX)'''（中文：[[頭孢氨芐]]）
			==Common Strengths of Cefalexin==
			Cefalexin is available in several strengths including:
			*125 mg
			*250 mg
			*500 mg

			==Drug Tarde Name of Cefalexin==
			Cefalexin is marketed under various trade names, including:
			*Keflex

			==Drug Usage==
			Cefalexin is used to treat bacterial infections such as:
			*Respiratory tract infections
			*Otitis media (ear infections)
			*Skin and soft tissue infections
			*Bone and joint infections
			*Urinary tract infections (UTIs)
			*Dental infections
			It is not effective against viral infections or certain resistant bacteria like MRSA.

			==Mechanism of Action==
			Cefalexin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the peptidoglycan layer, which is essential for bacterial cell wall integrity, leading to cell lysis and death.

			==Route of Administration==
			Oral

			==Dosages==
			*Normal aadults: 250 mg to 500 mg every 6 to 12 hours.
			*Renal Dose: For eGFR <60 mL/min, the maximum daily dose should not exceed 1000 mg.

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="5" \| '''Common Side Effects
			\| Nausea
			\|-
			\| Diarrhea
			\|-
			\| Stomach pain
			\|-
			\| Rash
			\|-
			\| Dizziness
			\|-
			\| rowspan="5" \| '''Serious Side Effects
			\| Severe allergic reactions (anaphylaxis)
			\|-
			\| Clostridium difficile infection (severe diarrgea)
			\|-
			\| Liver dysfunction (yellowing of skin/eyes)
			\|-
			\| Nephrotoxicity in patients with renal impairment
			\|}

			==Pharmacokinetics==
			*Onset of Action: Typically, within 1 hour.
			*Duration: Therapeutic levels maintained for 6 to 8 hours.
			*Half-life: Approximately 1 hour in individuals with normal renal function.

			==Drug Precautions==
			'''Pregnancy

			Cefalexin is generally considered safe during pregnancy, but it should only be used if clearly needed.

			'''Breastfeeding

			Cefalexin is excreted in breast milk in small amounts; it is usually deemed safe but should be used with caution.

			'''Children and Elderly

			Cefalexin can be used in children and the elderly, with dosage adjustments based on weight and renal function.

			'''Monitoring Requirements

			Regular monitoring of renal function is recommended, especially in patients with pre-existing conditions or those on other nephrotoxic medications.

			'''Drug Interactions

			Cefalexin may interact with:
			*Warfarin: Cefalexin can enhance the anticogulant effect of warfarin, increasing the risk of bleeding.
			*Metformin: The combination may increase metformin levels, leading to a higher risk of lactic aicdosis.
			*Furosemide (Lasix): Co-administration can impair kidney function, so renal function should be monitored.
			*Aminoglycosides: Using cephalexin with aminoglycoside antibiotics raises the risk of nephrotoxicty, necessitating careful monitoring of kidney function.
			*Probenecid: This gout medication can increase cefalexin levels in blood, potentially enhancing side effects
			*Caffeine: May exacerbate gastrointestinal side effects when taken with cefalexin.
			*Zinc Supplements: Zinc can reduce the absorption of cefalexin; it's advosable tp space their intake by at least three hours.

			==FAQ==
			'''How Should I Take the Tablet?

			Swallow cefalexin tablets whole with a glass of water. Do not chew or break them. It can be taken with or without food.

			'''What Should I Avoid While Taking?

			Avoid alcohol, as it may exacerbate side effects like nausea.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember, but skip it if it is almost time for your next dose. Do not double up on doses.

Zeki: Created page with "Category: DrugsCategory: First Generation Cephalosporin Antibiotic '''Oral Antibiotics''' '''Drug class: :Category: First Generation C..."

2024-09-30T03:50:33Z

Created page with "Category: Drugs Category: First Generation Cephalosporin Antibiotic '''Oral Antibiotics''' '''Drug class: :Category: First Generation C..."

New page

[[Category: Drugs]][[Category: First Generation Cephalosporin Antibiotic]]

[[:Category: Antibiotics | '''Oral Antibiotics''']]

'''Drug class: [[:Category: First Generation Cephalosporin Antibiotic | First-Generation Cephalosporin Antibiotic]]'''

'''Cefalexin (KEFLEX)'''（中文：[[頭孢氨芐]]）

Cefalexin - Revision history

Zeki at 06:06, 30 September 2024

Zeki: Created page with "Category: DrugsCategory: First Generation Cephalosporin Antibiotic '''Oral Antibiotics''' '''Drug class: :Category: First Generation C..."