Zeki at 03:21, 21 November 2024

2024-11-21T03:21:43Z

← Older revision		Revision as of 23:21, 20 November 2024
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	'''Drug class: [[:Category: Fourth Generation Cephalosporin Antibiotic \| Fourth-Generation Cephalosporin Antibiotic]]'''; beta-lactam antibiotics class, specifically categorized as a Fourth-generation cephalosporin.		'''Drug class: [[:Category: Fourth Generation Cephalosporin Antibiotic \| Fourth-Generation Cephalosporin Antibiotic]]'''; beta-lactam antibiotics class, specifically categorized as a Fourth-generation cephalosporin.

	'''Cefepime''' (中文：[[頭孢吡肟]])		'''Cefepime (Maxipime)''' (中文：[[頭孢吡肟]])
			==Common Strengths==
			Cefepime injections available in the following strengths:
			*1 g per vial

			==Trade Name==
			Maxipime

			==Drug Usage==
			Cefepime is a fourth-generation cephalosporin antibiotic that belongs to the beta-lactam class. It is used to treat a variety of bacterial infections, particularly those caused by gram-positive and gram-negative organisms.

			Cefepime is indicated for:
			*Pneumonia
			*Complicated and uncomplicated urinary tract infections
			*Skin and soft tissue infections
			*Complicated intra-abdominal infections (in combination with metronidazole)
			*Empiric treatment for febrile neutropenia

			==Mechanism of Action==
			Cefepime disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation, which leads to cell lysis and death of the bacteria.

			==Route of Administration==
			Intravenous (IV) injection

			==Dosages==
			Normal Adults:
			*Typical dosing is 2 g IV every 8 hours for severe infections or every 12 hours for moderate infections.
			Renal Impairment: Dosage adjustments are necessary based on creatinine clearance (CrCl):
			*CrCl >60 mL/min: 2 g IV every 8 hours
			*CrCl 30-60 mL/min: 2 g IV every 12 hours
			*CrCl 10-29 mL/min: 1 g IV every 24 hours
			*CrCl <10 mL/min: 500 mg IV every 24 hours

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="4" \| '''Common Side Effects
			\| Diarrhea
			\|-
			\| Nausea
			\|-
			\| Rash
			\|-
			\| Injection site reactions
			\|-
			\| rowspan="3" \| '''Serious Side Effects
			\| Neurotoxicity (e.g. seizures)
			\|-
			\| Allergic reactions (e.g. anaphylaxis)
			\|-
			\| Clostridium difficile-associated diarrhea
			\|}

			==Pharmacokinetics==
			*Cefepime has a half-life of approximately 2 hours in patients with normal renal function.
			*Onset Time: Rapid onset after IV administration.
			*Duration of Action: Generally lasts for about 8 to 12 hours.

			==Drug Precautions==
			'''Pregnancy

			Use with caution; benefits should outweigh risks.

			'''Breastfeeding

			Minimal risk to infants; use under medical advice.

			'''Children and Elderly

			Safety in children under two months is not established; the elderly may require dose adjustments due to renal function decline.

			'''Monitoring Items
			*Renal function (creatinine clearance)
			*Signs of neurotoxicity
			*Efficacy of treatment (resolution of infection)

			'''Drug Interactions
			*Aminoglycosides (e.g. gentamicin): Increased risk of nephrotoxicity.
			*Frusemide: Concurrent use can lead to an increased risk of nephrotoxicity.
			*Warfarin: Cefepime may elevate INR, increasing bleeding risk, particularly in patients with renal dysfunction.
			*BCG vaccine (live): Concurrent use is not recommended as it may adversely affect treatment outcomes.
			*Cholera and Typhoid vaccines: Th efficacy of these live vaccines may be reduced when administered with cefepime.

			==FAQ==
			'''How Should I Take the Cefepime?

			Cefepime is administered via injection.

			'''What Should I Avoid during Treatment?

			Avoid alcohol, as it may increase side effects. Consult your doctor about other medications you are taking to avoid interactions.

Zeki: Created page with "Category: DrugsCategory: Fourth Generation Cephalosporin Antibiotic '''Oral Antibiotics''' '''Drug class: :Category: Fourth Generation..."

2024-11-21T02:46:05Z

Created page with "Category: Drugs Category: Fourth Generation Cephalosporin Antibiotic '''Oral Antibiotics''' '''Drug class: :Category: Fourth Generation..."

New page

[[Category: Drugs]][[Category: Fourth Generation Cephalosporin Antibiotic]]

[[:Category: Antibiotics | '''Oral Antibiotics''']]

'''Drug class: [[:Category: Fourth Generation Cephalosporin Antibiotic | Fourth-Generation Cephalosporin Antibiotic]]'''; beta-lactam antibiotics class, specifically categorized as a Fourth-generation cephalosporin.

'''Cefepime''' (中文：[[頭孢吡肟]])

Cefepime - Revision history

Zeki at 03:21, 21 November 2024

Zeki: Created page with "Category: DrugsCategory: Fourth Generation Cephalosporin Antibiotic '''Oral Antibiotics''' '''Drug class: :Category: Fourth Generation..."