Clobazam - Revision history

Zeki at 02:13, 29 August 2024

2024-08-29T02:13:36Z

← Older revision		Revision as of 22:13, 28 August 2024
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	[[Category: Drugs]][[Category:~~benzodiazepine~~]]		[[Category: Drugs]][[Category: Benzodiazepine]]
	'''Clobazam'''~~(中文:~~[[氯巴占]]) is a long-acting benzodiazepine with antiepileptic properties. It may be used as an adjunct with other antiepileptics in the treatment of epilepsy including seizzures associated with the Lennox-Gastaut syndrome, although its use may be limited by the development of tolerance or sedation. It is also used in the short-term treatment of acute anxiety.
			[[:Category: Anxiolytic and Hypnotic Drugs \| '''Anxiolytic and Hypnotic Drugs''']]

			'''Drug class: [[:Category: Benzodiazepine \| Benzodiazepine, BDZs]]

			'''Clobazam (FRISIUM)'''（中文：[[氯巴占]]） is a long-acting benzodiazepine with antiepileptic properties. It may be used as an adjunct with other antiepileptics in the treatment of epilepsy including seizzures associated with the Lennox-Gastaut syndrome, although its use may be limited by the development of tolerance or sedation. It is also used in the short-term treatment of acute anxiety.

	==Pronunciation==		==Pronunciation==

Helen at 06:43, 20 October 2020

2020-10-20T06:43:00Z

← Older revision		Revision as of 02:43, 20 October 2020
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	[[Category: Drugs]][[Category:benzodiazepine]]		[[Category: Drugs]][[Category:benzodiazepine]]
	'''Clobazam'''(中文:[[~~氯巴贊~~]]) is a long-acting benzodiazepine with antiepileptic properties. It may be used as an adjunct with other antiepileptics in the treatment of epilepsy including seizzures associated with the Lennox-Gastaut syndrome, although its use may be limited by the development of tolerance or sedation. It is also used in the short-term treatment of acute anxiety.		'''Clobazam'''(中文:[[氯巴占]]) is a long-acting benzodiazepine with antiepileptic properties. It may be used as an adjunct with other antiepileptics in the treatment of epilepsy including seizzures associated with the Lennox-Gastaut syndrome, although its use may be limited by the development of tolerance or sedation. It is also used in the short-term treatment of acute anxiety.

	==Pronunciation==		==Pronunciation==

Helen: /* Drug interaction */

2020-10-20T06:41:07Z

Drug interaction

← Older revision		Revision as of 02:41, 20 October 2020
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	\|		\|
	Steroid (e.g. Dexamethasone)		Steroid (e.g. Dexamethasone)

	St John’s wort		St John’s wort
	\|Increase the metabolism of clobazam, thus decreasing clobazam plasma levels and effects		\|Increase the metabolism of clobazam, thus decreasing clobazam plasma levels and effects

Helen: /* FAQ */

2020-10-20T06:40:42Z

FAQ

← Older revision		Revision as of 02:40, 20 October 2020
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	Do not drink any alcohol or use recreational drugs while taking clobazam.		Do not drink any alcohol or use recreational drugs while taking clobazam.

	==== What happen if I overdose? ====		=== What happen if I overdose? ===
	Contact your primary care doctor.		Contact your primary care doctor.
	If emergency situation, call 999		If emergency situation, call 999
	==== What happen if I miss a dose? ====		=== What happen if I miss a dose? ===
	Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.		Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Helen: /* How should I take the tablet? */

2020-10-20T06:40:26Z

How should I take the tablet?

← Older revision		Revision as of 02:40, 20 October 2020
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	== FAQ ==		== FAQ ==
	==== How should I take the tablet? ====		=== How should I take the tablet? ===
	If you get nauseous after taking Clobazam on on an empty stomach, try taking it with food.		If you get nauseous after taking Clobazam on on an empty stomach, try taking it with food.

	=== What should I avoid while taking? ===		=== What should I avoid while taking? ===
	Do not eat grapefruit or drink grapefruit juice.		Do not eat grapefruit or drink grapefruit juice.

Helen: /* What should I avoid while taking? */

2020-10-20T06:40:14Z

What should I avoid while taking?

← Older revision		Revision as of 02:40, 20 October 2020
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	==== How should I take the tablet? ====		==== How should I take the tablet? ====
	If you get nauseous after taking Clobazam on on an empty stomach, try taking it with food.		If you get nauseous after taking Clobazam on on an empty stomach, try taking it with food.
	==== What should I avoid while taking? ====		=== What should I avoid while taking? ===
	Do not eat grapefruit or drink grapefruit juice.		Do not eat grapefruit or drink grapefruit juice.
	Do not drink any alcohol or use recreational drugs while taking ~~clonazepam~~.
			Do not drink any alcohol or use recreational drugs while taking clobazam.

	==== What happen if I overdose? ====		==== What happen if I overdose? ====
	Contact your primary care doctor.		Contact your primary care doctor.

Helen: /* Caution */

2020-10-20T06:38:38Z

Caution

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	*avoid prolonged use and abrupt withdrawal thereafter		*avoid prolonged use and abrupt withdrawal thereafter

	====Contra-indications====		===Contra-indications===
	Bromazepam is contraindicated in patients with:		Bromazepam is contraindicated in patients with:
	*severe hepatic impairment		*severe hepatic impairment
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	*Chronic schizophrenia		*Chronic schizophrenia

	====Hepatic impairment====		===Hepatic impairment===
	*Start with smaller initial doses or reduce dose.		*Start with smaller initial doses or reduce dose.
	*Can precipitate coma.		*Can precipitate coma.
			*Avoid in sever impairment

	====Renal impairment====		===Renal impairment===
	*Start with small doses in severe impairment.		*Start with small doses in severe impairment.

	====Pregnancy====		===Pregnancy===
	Possible adverse effects of use of benzodiazepines such as Clobazam during pregnancy include: miscarriage, malformation, intrauterine growth retardation, and function deficits.		Possible adverse effects of use of benzodiazepines such as Clobazam during pregnancy include: miscarriage, malformation, intrauterine growth retardation, and function deficits.

	====Breast-feeding====		===Breast-feeding===
	Use during breast feeding is not recommended.		Use during breast feeding is not recommended.

	====Driving and skilled tasks====		===Driving and skilled tasks===
	May impair judgment and increase reaction time, and so affect ability to drive or operate machinery. Patients should be warned not to operate dangerous machinery or motor vehicles until it is known that they do not become drowsy from clonazepam therapy.		May impair judgment and increase reaction time, and so affect ability to drive or operate machinery. Patients should be warned not to operate dangerous machinery or motor vehicles until it is known that they do not become drowsy from clonazepam therapy.

Helen: /* Drug interaction */

2020-10-20T06:35:10Z

Drug interaction

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	\|Food that alkalinize the urine		\|Food that alkalinize the urine
	\|Can lead to slower absorption and elimination of clobazam, increasing the clobazam plasma levels and effects.		\|Can lead to slower absorption and elimination of clobazam, increasing the clobazam plasma levels and effects.
	\|}

	\|}		\|}

Helen: /* Drug interaction */

2020-10-20T06:34:26Z

Drug interaction

@@ Line 131: / Line 131: @@
+|
 Alcohol,
 Hypnotics/sedative (e.g. barbiturates)
 Antidepressants (e.g. fluoxetine, amitriptyline)
 Sedative histamines (e.g. promethazine)
 Antipsychotic (e.g. chlorpromazine, clozapine)
 |May worsens the side effects such as drowsiness , dizziness and respiratory depression
@@ Line 139: / Line 143: @@
+|
 Cimetidine
 Omeprazole
 Oxcarbazepine, topiramate, valproate
 Ketoconazole
 Itraconazole
 Isoniazid
 Erythromycin, ciprofloxacin
 Propranolol
 fluoxetine
 |Prolong the action of clobazam by inhibiting its elimination
 |}

Helen: /* Drug interaction */

2020-10-20T06:30:56Z

Drug interaction

← Older revision		Revision as of 02:30, 20 October 2020
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	Common medications that may interact with diazepam include:		Common medications that may interact with diazepam include:
			{\| class = "wikitable"
			!style="text-align: left"\| Drugs given with diazepam
			!style="text-align: left"\| Potential Effect
			\|-
			\|
			Alcohol,
			Hypnotics/sedative (e.g. barbiturates)
			Antidepressants (e.g. fluoxetine, amitriptyline)
			Sedative histamines (e.g. promethazine)
			Antipsychotic (e.g. chlorpromazine, clozapine)
			\|May worsens the side effects such as drowsiness , dizziness and respiratory depression
			\|-
			\|
			Cimetidine
			Omeprazole
			Oxcarbazepine, topiramate, valproate
			Ketoconazole
			Itraconazole
			Isoniazid
			Erythromycin, ciprofloxacin
			Propranolol
			fluoxetine
			\|Prolong the action of clobazam by inhibiting its elimination
			\|}

	===Caution===		===Caution===