Zeki at 08:05, 8 August 2024

2024-08-08T08:05:59Z

← Older revision		Revision as of 04:05, 8 August 2024
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	\| Increased bleeding risk		\| Increased bleeding risk
	\|}		\|}

			==FAQ==
			'''How Should I Take the Tablet?

			Do not chew or crush the tablet. Take the tablet whole with or without food, at approximately the same time each day.

			'''What Should I Avoid While Taking?

			Avoid alcohol and operating heavy machinery until you know how desvenlafaxine affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Zeki at 08:01, 8 August 2024

2024-08-08T08:01:43Z

← Older revision		Revision as of 04:01, 8 August 2024
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	'''Desvenlafaxine (PRISTIQ)'''（中文：[[去甲文拉法辛]]）		'''Desvenlafaxine (PRISTIQ)'''（中文：[[去甲文拉法辛]]）
			==Common Strengths of Desvenlafaxine==
			Desvenlafaxine are available in the following strengths:
			*25 mg, 50 mg, 100 mg

			==Drug Trade Names of Desvenlafaxine==
			Pristiq

			==Drug Usage==
			Desvenlafaxine is primarily used to treat:
			*Major depressive disorder (MDD) in adults

			==Mechanism of Action==
			Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It works by inhibiting the reuptake of serotonin and norepinephrine, increasing their levels in the brain.

			==Route of Administration==
			Oral (extended-release tablets)

			==Dosages==
			The recommended dose is 50 mg once daily

			Renal dose based on eGFR:
			*eGFR ≥50 mL/min: No dosage adjustment is needed
			*eGFR 30 - 50 mL/min: Maximum 50 mg/day
			*eGFR <30 mL/min: Maximum 25 mg/day or 50 mg every

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="10" \| '''Common
			\| Nausea: Stick to simple meals and avoid rich or spicy foods
			\|-
			\| Dry Mouth: Chew sugar-free gum or sweets
			\|-
			\| Excessive Sweating: Wear loose clothing and use a fan if needed
			\|-
			\| Dizziness: Get up slowly from sitting or lying positions
			\|-
			\| Constipation: Increase fiber intake and drink plenty of water
			\|-
			\| Insomnia: Take in the morning
			\|-
			\| Decreased Appetite
			\|-
			\| Fatigue or Sleepiness
			\|-
			\| Anxiety
			\|-
			\| Sexual Dysfunction: includes decreased libido and difficulty achieving orgasm
			\|-
			\| rowspan="10" \| '''Serious
			\| '''Serious side effects are less common but require immediate medical attention'''
			\|-
			\| Suicidal Thoughts or Actions: especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusual changes in mood or behavior.
			\|-
			\| Serotonin Syndrome: This potentially life-threatening condition can occur when there is too much serotonin in the body. Symptoms include agitation, hallucinations, rapid heart rate, fever, nausea, vomiting, diarrhea, and muscle twitching
			\|-
			\| Severe Allergic Reactions: These include symptoms like difficulty breathing, swelling of the face, lips, tongue, or throat, and severe rash or hives
			\|-
			\| Abnormal Bleeding: Can manifest as unusual bruising or bleeding
			\|-
			\| Low Sodium Levels: Particularly in older adults, symptoms include headache, confusion, weakness, and difficulty concentrating
			\|-
			\| Mania: Symptoms include excessively high energy, severe trouble sleeping, racing thoughts, reckless behavior, and unusually grand ideas
			\|-
			\| Eye Problems- Such as blurred vision, eye pain, or swelling, which may indicate glaucoma
			\|-
			\| Seizures
			\|-
			\| High blood pressure
			\|}

			==Pharmacokinetics==
			*Metabolism: Primarily through conjugation, minor oxidative metabolism
			*Elimination: 45% excreted unchanged in urine. Half-life of about 11 hours
			*Onset of action: 1 to 4 weeks for full antidepressant effect

			==Drug Precautions==
			'''Pregnancy

			Use with caution; potential risks to the fetus.

			'''Breastfeeding

			Use with caution; desvenlafaxine is excreted in breast milk

			'''Children and Elderly
			*Not approved for use in children
			*Elderly may be more sensitive to side effects; lower doses may be needed

			'''Monitoring Requirements
			*Blood pressure
			*Signs of serotonin syndrome

			'''Drug Interactions
			{\| class="wikitable"
			!style="text-align: left"\| Interaction Type
			!Examples
			!Notes
			\|-
			\| Major
			\| Other serotonergic drugs include other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, and St. John’s Wort.
			\| Risk of serotonin syndrome
			\|-
			\| Moderate
			\| Antiplatelets, Anticoagulants, NSAID, CYP2D6 substrates: dextromethorphan, metoprolol, nebivolol, tolterodine
			\| Increased bleeding risk
			\|}

Zeki: Created page with "Category: DrugsCategory: Serotonin-norepinephrine reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Serot..."

2024-08-08T07:23:23Z

Created page with "Category: Drugs Category: Serotonin-norepinephrine reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Serot..."

New page

[[Category: Drugs]][[Category: Serotonin-norepinephrine reuptake inhibitor]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Serotonin-norepinephrine reuptake inhibitor | Serotonin-Norepinephrine Reuptake Inhibitor]]

'''Desvenlafaxine (PRISTIQ)'''（中文：[[去甲文拉法辛]]）

Desvenlafaxine - Revision history

Zeki at 08:05, 8 August 2024

Zeki at 08:01, 8 August 2024

Zeki: Created page with "Category: DrugsCategory: Serotonin-norepinephrine reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Serot..."