Diazepam - Revision history

Ctol2: /* Drug Management */

2020-10-20T06:54:42Z

Drug Management

← Older revision		Revision as of 02:54, 20 October 2020
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	\|-		\|-
	\|style="text-align: left"\|		\|style="text-align: left"\|
	Alcohol,		*Alcohol,
	Hypnotics/sedative (e.g. barbiturates)		*Hypnotics / sedative (e.g. [[barbiturates]])
	Antidepressants (e.g. fluoxetine, amitriptyline)		*Antidepressants (e.g. [[fluoxetine]], [[amitriptyline]])
	Sedative histamines (e.g. promethazine)		*Sedative histamines (e.g. [[promethazine]])
	Antipsychotic (e.g. chlorpromazine, clozapine)		*Antipsychotic (e.g. [[chlorpromazine]], [[clozapine]])
	\|May worsens the side effects such as drowsiness , dizziness and respiratory depression		\|May worsens the side effects such as drowsiness , dizziness and respiratory depression
	\|-		\|-
	\|style="text-align: left"\|		\|style="text-align: left"\|
	Cimetidine		*[[Cimetidine]]
	Omeprazole		*[[Omeprazole]]
	Oxcarbazepine, ~~topiramate~~, ~~valproate~~		*[[Oxcarbazepine]], [[Topiramate]], [[Valproate]]
	Ketoconazole		*[[Ketoconazole]]
	Itraconazole		*[[Itraconazole]]
	Isoniazid		*[[Isoniazid]]
	Erythromycin, ~~ciprofloxacin~~		*[[Erythromycin]], [[Ciprofloxacin]]
	Propranolol		*[[Propranolol]]
	~~fluoxetine~~		*[[Fluoxetine]]
	\|'''Prolong the action''' of diazepam by inhibiting its elimination		\|'''Prolong the action''' of diazepam by inhibiting its elimination
	\|-		\|-
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	\|style="text-align: left"\|		\|style="text-align: left"\|
	Rifampicin		*[[Rifampicin]]
	Phenytoin		*[[Phenytoin]]
	Carbamazepine		*[[Carbamazepine]]
	~~phenobarbitone~~		*[[Phenobarbitone]]
	\|All these drugs increase the metabolism of diazepam, thus decreasing drug levels and effects		\|All these drugs increase the metabolism of diazepam, thus decreasing drug levels and effects
	\|-		\|-
	\|style="text-align: left"\|		\|style="text-align: left"\|
	Steroid (e.g. Dexamethasone)		*Steroid (e.g. [[Dexamethasone]])
	St John’s wort		*St John’s wort
	\|Increase the metabolism of diazepam, thus decreasing diazepam plasma levels and effects		\|Increase the metabolism of diazepam, thus decreasing diazepam plasma levels and effects
	\|-		\|-
	\|style="text-align: left"\| Theophylline		\|style="text-align: left"\| [[Theophylline]]
	\|May inhibit the action of diazepam		\|May inhibit the action of diazepam
	\|-		\|-
	\|style="text-align: left"\| Levodopa (e.g. Sinemet)		\|style="text-align: left"\| [[Levodopa]] (e.g. [[Sinemet]])
	\|Diazepam may block the action of levodopa used in the treatment of Parkinson’s disease.		\|Diazepam may block the action of levodopa used in the treatment of Parkinson’s disease.
	\|-		\|-
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	===Driving and skilled tasks===		===Driving and skilled tasks===
	May impair judgment and increase reaction time, and so affect ability to drive or operate machinery. Patients should be warned not to operate dangerous machinery or motor vehicles until it is known that they do not become drowsy from diazepam therapy.		May impair judgment and increase reaction time, and so affect ability to drive or operate machinery. Patients should be warned not to operate dangerous machinery or motor vehicles until it is known that they do not become drowsy from diazepam therapy.

	== FAQ ==		== FAQ ==

Ctol2 at 05:43, 20 October 2020

2020-10-20T05:43:41Z

← Older revision		Revision as of 01:43, 20 October 2020
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	[[Category: Drugs]][[Category:benzodiazepine]]		[[Category: Drugs]][[Category:benzodiazepine]]
	'''Diazepam''' (中文:[[地西泮]]) is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant properties. It is used:		'''Diazepam''' (中文: [[地西泮]]) is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant properties. It is used:
	*In the short-term treatment of severe anxiety disorders;		*In the short-term treatment of severe anxiety disorders;
	*As a hypnotic in the short-term treatment of insomnia;		*As a hypnotic in the short-term treatment of insomnia;

Ctol2 at 05:43, 20 October 2020

2020-10-20T05:43:31Z

← Older revision		Revision as of 01:43, 20 October 2020
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	[[Category: Drugs]][[Category:benzodiazepine]]		[[Category: Drugs]][[Category:benzodiazepine]]
	'''Diazepam''' (中文:[[ 地西泮 ]])is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant properties. It is used:		'''Diazepam''' (中文:[[地西泮]]) is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant properties. It is used:
	*In the short-term treatment of severe anxiety disorders;		*In the short-term treatment of severe anxiety disorders;
	*As a hypnotic in the short-term treatment of insomnia;		*As a hypnotic in the short-term treatment of insomnia;

Helen at 05:35, 19 October 2020

2020-10-19T05:35:45Z

← Older revision		Revision as of 01:35, 19 October 2020
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	[[Category: Drugs]][[Category:benzodiazepine]]		[[Category: Drugs]][[Category:benzodiazepine]]
	'''Diazepam''' (中文:[[ ]])is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant properties. It is used:		'''Diazepam''' (中文:[[ 地西泮 ]])is a long-acting benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant properties. It is used:
	*In the short-term treatment of severe anxiety disorders;		*In the short-term treatment of severe anxiety disorders;
	*As a hypnotic in the short-term treatment of insomnia;		*As a hypnotic in the short-term treatment of insomnia;

Helen at 04:50, 14 October 2020

2020-10-14T04:50:55Z

← Older revision		Revision as of 00:50, 14 October 2020
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	{\| class = "wikitable"		{\| class = "wikitable"
	\|style="text-align: left"\|~~'''~~Very common~~'''~~ (>10% of incidence)		!style="text-align: left"\| Very common (>10% of incidence)
	or~~'''~~ Common ~~'''~~(1-10% of incidence)		or Common(1-10% of incidence)
	\|		\|
	*Shakiness and unsteady walk (especially in the elderly)		*Shakiness and unsteady walk (especially in the elderly)
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	*Paradoxical increase in aggression		*Paradoxical increase in aggression
	\|-		\|-
	\|style="text-align: left"\|~~'''~~Infrequent~~'''~~ (0.1 -1% of incidence)		!style="text-align: left"\| Infrequent (0.1 -1% of incidence)
	\|		\|
	*Dysarthria		*Dysarthria
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	*Visual disturbances		*Visual disturbances
	\|-		\|-
	\|style="text-align: left"\| ~~'''~~Rare~~'''~~ (<0.1% of incidence)		!style="text-align: left"\| Rare (<0.1% of incidence)
	\|		\|
	*Apnoea		*Apnoea
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	Common medications that may interact with diazepam include:		Common medications that may interact with diazepam include:
	{\| class="wikitable"		{\| class="wikitable"
	!Drugs given with diazepam		!style="text-align: left"\| Drugs given with diazepam
	!Potential Effect		!style="text-align: left"\| Potential Effect
	\|-		\|-
	\|style="text-align: left"\|		\|style="text-align: left"\|

Helen: /* What should I avoid while taking? */

2020-10-12T03:26:09Z

What should I avoid while taking?

← Older revision		Revision as of 23:26, 11 October 2020
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	=== What should I avoid while taking? ===		=== What should I avoid while taking? ===
	Do not eat grapefruit or drink grapefruit juice as it may increase blood levels of diazepam.		Do not eat grapefruit or drink grapefruit juice as it may increase blood levels of diazepam.

	Avoid drinking alcohol while taking diazepam because it may enhance the side effects of sedation and respiratory depression.		Avoid drinking alcohol while taking diazepam because it may enhance the side effects of sedation and respiratory depression.

	Avoid driving or hazardous activity until you know how diazepam will affect you.		Avoid driving or hazardous activity until you know how diazepam will affect you.
	==== What happen if I overdose? ====		==== What happen if I overdose? ====

Helen: /* FAQ */

2020-10-12T03:25:56Z

FAQ

← Older revision		Revision as of 23:25, 11 October 2020
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	== FAQ ==		== FAQ ==
			=== How should I take the tablet? ===
			May be taken with or without food. Swallow whole with a glass of water.
			=== What should I avoid while taking? ===
			Do not eat grapefruit or drink grapefruit juice as it may increase blood levels of diazepam.
			Avoid drinking alcohol while taking diazepam because it may enhance the side effects of sedation and respiratory depression.
			Avoid driving or hazardous activity until you know how diazepam will affect you.
	==== What happen if I overdose? ====		==== What happen if I overdose? ====
	Contact your primary care doctor.		Contact your primary care doctor.

Helen: /* Drug Management */

2020-10-12T03:24:57Z

Drug Management

← Older revision		Revision as of 23:24, 11 October 2020
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	Can lead to slower absorption and elimination of diazepam, increasing the diazepam plasma levels and effects.		Can lead to slower absorption and elimination of diazepam, increasing the diazepam plasma levels and effects.
	\|}		\|}

			===Caution===
			*particular care in pregnancy,
			*elderly, due to increased susceptibility to side-effects, especially loss of coordination and drowsiness
			*in patients with hepatic or renal impairment, who may require reduced doses
			*people with history of alcohol dependence or abuse
			*people with history of drug dependence or abuse
			*people with psychiatric disorders
			*avoid prolonged use and abrupt withdrawal thereafter

			===Contra-indications===
			Use of diazepam should be avoided, when possible, in individuals with:
			*severe hepatic impairment
			*sleep apnoea
			*chronic obstructive airways disease (COPD)
			*Myasthenia gravis
			*Acute narrow-angle glaucoma
			*Chronic schizophrenia

			===Hepatic impairment===
			*Start with smaller initial doses or reduce dose.
			*Can precipitate coma.
			*Avoid in severe impairment.

			===Renal impairment===
			*Start with small doses in severe impairment.

			===Pregnancy===
			Possible adverse effects of use of benzodiazepines such as diazepam during pregnancy include: miscarriage, malformation, intrauterine growth retardation, and function deficits.

			===Breast-feeding===
			Use during breast feeding is not recommended.

			===Driving and skilled tasks===
			May impair judgment and increase reaction time, and so affect ability to drive or operate machinery. Patients should be warned not to operate dangerous machinery or motor vehicles until it is known that they do not become drowsy from diazepam therapy.

			== FAQ ==
			==== What happen if I overdose? ====
			Contact your primary care doctor.
			If emergency situation, call 999
			==== What happen if I miss a dose? ====
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Helen: /* Drug interaction */

2020-10-12T03:21:49Z

Drug interaction

← Older revision		Revision as of 23:21, 11 October 2020
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	Foods that acidify the urine		Foods that acidify the urine

	Food that alkalinize the urine		Food that alkalinize the urine
	\|Can lead to faster absorption and elimination of diazepam, reducing drug levels and effects.		\|Can lead to faster absorption and elimination of diazepam, reducing drug levels and effects.
	Can lead to slower absorption and elimination of diazepam, increasing the diazepam plasma levels and effects.		Can lead to slower absorption and elimination of diazepam, increasing the diazepam plasma levels and effects.
	\|}		\|}

Helen: /* Drug interaction */

2020-10-12T03:21:35Z

Drug interaction

← Older revision		Revision as of 23:21, 11 October 2020
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	\|-		\|-
	\|style="text-align: left"\|		\|style="text-align: left"\|
	Foods that acidify the urine		Foods that acidify the urine
	Food that alkalinize the urine		Food that alkalinize the urine
	\|Can lead to faster absorption and elimination of diazepam, reducing drug levels and effects.		\|Can lead to faster absorption and elimination of diazepam, reducing drug levels and effects.
	Can lead to slower absorption and elimination of diazepam, increasing the diazepam plasma levels and effects.		Can lead to slower absorption and elimination of diazepam, increasing the diazepam plasma levels and effects.
	\|}		\|}