Diclofenac Sodium - Revision history

Helen: /* Side Effects */

2020-10-14T02:12:01Z

Side Effects

← Older revision		Revision as of 22:12, 13 October 2020
Line 89:		Line 89:
	==Side Effects==		==Side Effects==
	As for NSAIDs in general.		As for NSAIDs in general.
	Common side effects ~~include heartburn~~, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.		{\| class = "wikitable"
			!style="text-align: left"\| Common side effects
			\|Heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.
			\|}
	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

	{\| class="wikitable"		{\| class="wikitable"
	!Diclofenac suppositories		!Diclofenac suppositories

Helen: /* Mechanism of Action */

2020-10-14T02:10:23Z

Mechanism of Action

← Older revision		Revision as of 22:10, 13 October 2020
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	==Mechanism of Action==		==Mechanism of Action==
	~~非鴉片類止痛藥~~		Anti-inflammatory agent,
			Non-steroidal anti-inflammatory drug (NSAID)
	~~非類固醇消炎止痛藥~~(NSAID),		Non-selective COX inhibitor

	~~非選擇性環氧合酶抑製劑~~

	==Dosage==		==Dosage==

Helen at 06:47, 12 October 2020

2020-10-12T06:47:03Z

← Older revision		Revision as of 02:47, 12 October 2020
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	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

	~~NSAID can also worsen asthma.~~

	{\| class="wikitable"		{\| class="wikitable"
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	\|-		\|-
	!Diclofenac such as plasters and gel		!Diclofenac such as plasters and gel
	\|May cause application site reactions.		\|May cause application site reactions
			\|-
			!Asthma
			\|Can be worsen
	\|-		\|-
	!Cardiovascular risk		!Cardiovascular risk

Helen: /* Side Effects */

2020-10-12T06:41:46Z

Side Effects

← Older revision		Revision as of 02:41, 12 October 2020
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	!Diclofenac such as plasters and gel		!Diclofenac such as plasters and gel
	\|May cause application site reactions.		\|May cause application site reactions.
			\|-
	!Cardiovascular risk		!Cardiovascular risk
	\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.		\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

Helen: /* Side Effects */

2020-10-12T06:41:28Z

Side Effects

← Older revision		Revision as of 02:41, 12 October 2020
Line 109:		Line 109:
	!Diclofenac such as plasters and gel		!Diclofenac such as plasters and gel
	\|May cause application site reactions.		\|May cause application site reactions.
	\|}

	~~{\| class="wikitable"~~
	!Cardiovascular risk		!Cardiovascular risk
	\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.		\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

Helen at 06:40, 12 October 2020

2020-10-12T06:40:30Z

← Older revision		Revision as of 02:40, 12 October 2020
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	!Skin		!Skin
	\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.		\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
			\|}

	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* Side Effects */

2020-10-12T06:39:47Z

Side Effects

← Older revision		Revision as of 02:39, 12 October 2020
Line 92:		Line 92:
	As for NSAIDs in general.		As for NSAIDs in general.
	Common side effects include heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.		Common side effects include heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.

			It also increases the risk of heart attack, stroke, kidney failure and liver failure.

			NSAID can also worsen asthma.

	{\| class="wikitable"		{\| class="wikitable"
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	\|-		\|-
	!Effects on the blood		!Effects on the blood
	\|Localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.		\|Localized spontaneous bleeding, bruising and prolonged bleeding time have been reported
			\|-
			!Diclofenac such as plasters and gel
			\|May cause application site reactions.
	\|}		\|}


	~~Topical preparations of diclofenac such as plasters and gel may cause application site reactions.~~

	~~It also increases the risk of heart attack, stroke, kidney failure and liver failure.~~

	~~NSAID can also worsen asthma.~~
	{\| class="wikitable"		{\| class="wikitable"
	!Cardiovascular risk		!Cardiovascular risk
	\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.		\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

	\|-		\|-
	\|Skin		!Skin
	\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.		\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.

Helen: /* Side Effects */

2020-10-12T06:36:32Z

Side Effects

← Older revision		Revision as of 02:36, 12 October 2020
Line 91:		Line 91:
	==Side Effects==		==Side Effects==
	As for NSAIDs in general.		As for NSAIDs in general.
			Common side effects include heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.

	Diclofenac suppositories ~~can~~ cause local irritation.		{\| class="wikitable"
			!Diclofenac suppositories
			\|Can cause local irritation
			\|-
			!Diclofenac eye drops
			\|Transient burning and stinging may occur
			\|-
			!Effects on the blood
			\|Localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.
			\|}

	~~Transient burning and stinging may occur with diclofenac eye drops.~~

	Topical preparations of diclofenac such as plasters and gel may cause application site reactions.		Topical preparations of diclofenac such as plasters and gel may cause application site reactions.

	~~Common side effects include heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.~~

	~~Effects on the blood: localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.~~

	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

	NSAID can also worsen asthma.		NSAID can also worsen asthma.
			{\| class="wikitable"
			!Cardiovascular risk
			\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

	~~'''Cardiovascular risk~~		\|-
	Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.		\|Skin
			\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
	~~'''~~Skin
	NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.

	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* oral dose */

2020-10-12T06:27:49Z

oral dose

← Older revision		Revision as of 02:27, 12 October 2020
Line 47:		Line 47:

	==Dosage==		==Dosage==
	~~===oral dose ===~~
	{\| class="wikitable"		{\| class="wikitable"
	!style="text-align: left"\| Oral		!style="text-align: left"\| Oral

Helen: /* Dosage */

2020-10-12T06:26:36Z

Dosage

← Older revision		Revision as of 02:26, 12 October 2020
Line 47:		Line 47:

	==Dosage==		==Dosage==
	===~~Usual~~ oral dose ~~for painful conditions~~===		===oral dose ===
	{\| class="wikitable"		{\| class="wikitable"
	!style="text-align: left"\| Oral		!style="text-align: left"\| Oral