Dihydrocodeine - Revision history

Helen: /* Introduction */

2020-10-05T07:34:23Z

Introduction

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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]
	==Introduction==		==Introduction==
	'''Dihydrocodeine is an opioid analgesic . It is used for the relief of moderate to severe pain, often in combination preparations with paracetamol. It has also been used as a cough suppressant.		'''Dihydrocodeine''' is an opioid analgesic . It is used for the relief of moderate to severe pain, often in combination preparations with paracetamol. It has also been used as a cough suppressant.

	{\| class="wikitable"		{\| class="wikitable"

2020-10-05T07:34:13Z

← Older revision		Revision as of 03:34, 5 October 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]
	Dihydrocodeine is an ~~'''~~opioid analgesic~~'''~~ . It is used for the relief of moderate to severe pain, often in combination preparations with paracetamol. It has also been used as a cough suppressant.		==Introduction==
			'''Dihydrocodeine is an opioid analgesic . It is used for the relief of moderate to severe pain, often in combination preparations with paracetamol. It has also been used as a cough suppressant.

	{\| class="wikitable"		{\| class="wikitable"

2020-10-05T03:30:38Z

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	\|Elimination half-life is reported to range from about 3.5 to 5 hours.		\|Elimination half-life is reported to range from about 3.5 to 5 hours.
	\|}		\|}

			==Drug Management==
			===Efficiency===
			Pain control
			===Safety===
			mental status, blood pressure, respiratory drive, and misuse / overuse.
			===Caution===
			Pancreatitis, severe cor pulmonale
			Tolerance and dependence

			== FAQ ==
			=== How should I take the tablet? ===
			Follow the doctor's prescription,
			Take with or without food
			Take the medication with plenty of water
			Can be crushed
			Do not crush modified-released tablet (DF-118)
			=== What should I avoid while taking? ===
			Avoid abrupt withdrawal
			=== What happen if I overdose? ===
			Emergency situation, called 999 immediately
			Antidote: Naloxone
			=== What happen if I miss a dose? ===
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

2020-10-05T03:28:05Z

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	===Treatment of Adverse Effects===		===Treatment of Adverse Effects===
	Abdominal pain, hyperthermia, pancreatitis Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression.		Abdominal pain, hyperthermia, pancreatitis Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression.

			==Pharmacokinetics==

			{\|class="wikitable"
			!Oral bioavailability
			\|Oral bioavailability is only about 20%, probably because of substantial first-pass metabolism in the gut wall or liver.
			\|-
			!Onset of action
			\|peak concentrations of dihydrocodeine occur about 1.2 to 1.8 hours after oral doses.
			\|-
			!Metabolism
			\|Dihydrocodeine is metabolized in the liver, and is excreted in urine.
			\|-
			!Elimination half-life
			\|Elimination half-life is reported to range from about 3.5 to 5 hours.
			\|}

2020-10-05T03:25:50Z

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	===Treatment of Adverse Effects===		===Treatment of Adverse Effects===
	~~#Constipation can be treated with laxatives such as senna tables and lactulose.~~		Abdominal pain, hyperthermia, pancreatitis Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression.
	~~#Nausea~~ and vomiting ~~can be alleviated by metoclopramide.~~
	~~#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe~~ respiratory depression and ~~coma~~.

2020-10-05T03:20:16Z

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	Older children may be given the usual adult dose.		Older children may be given the usual adult dose.

			==Side Effects==

			===As for Opioid Analgesic in general===

			The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.

			Large doses of opioids produce respiratory depression and hypotension, with circulatory failure and deepening coma. Death may occur from respiratory failure.

			===Treatment of Adverse Effects===
			#Constipation can be treated with laxatives such as senna tables and lactulose.
			#Nausea and vomiting can be alleviated by metoclopramide.
			#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe respiratory depression and coma.

2020-10-05T03:17:59Z

Dosage

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	\|50 mg every 4 to 6 hours.		\|50 mg every 4 to 6 hours.
	\|}		\|}

			Doses in children:

			*may be given orally, or by deep subcutaneous or intramuscular injection;

			1 to 3 years: 500 micrograms/kg every 4 to 6 hours

			4 to 12 years: 0.5 to 1 mg/kg every 4 to 6 hours

			Older children may be given the usual adult dose.

2020-10-05T03:17:28Z

Dosage

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	!Oral		!Oral
	\|30mg after food every 4 to 6 hours; up to 240mg daily.		\|30mg after food every 4 to 6 hours; up to 240mg daily.
			\|-
			\|
	\|Modified-release preparations are taken twice daily.		\|Modified-release preparations are taken twice daily.
	\|-		\|-

2020-10-05T03:17:08Z

@@ Line 44: / Line 44: @@
 !Route of Administration
 |PO (tablet form)
 |}

2020-10-05T03:15:45Z