Donepezil Hydrochloride - Revision history

Zeki at 07:48, 4 November 2024

2024-11-04T07:48:08Z

← Older revision		Revision as of 03:48, 4 November 2024
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	'''Donepezil hydrochloride''' (中文: [[~~多奈哌齊~~]]), is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.		'''Donepezil hydrochloride''' (中文: [[鹽酸多奈哌齊]]), is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.

	==Drug Names==		==Drug Names==

Zeki at 07:47, 4 November 2024

2024-11-04T07:47:08Z

← Older revision		Revision as of 03:47, 4 November 2024
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	~~[[Category: Drugs]][[Category:Acetylcholinesterase inhibiting drug ]]~~
	'''Donepezil hydrochloride''' (中文: [[多奈哌齊]]), is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.		'''Donepezil hydrochloride''' (中文: [[多奈哌齊]]), is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.

Helen: /* Dosage */

2020-10-12T06:01:44Z

Dosage

← Older revision		Revision as of 02:01, 12 October 2020
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	==Dosage==		==Dosage==
	By Oral~~: initially~~ 5 mg once daily at bedtime, increased if necessary, after one month to max. 10 mg daily.		{\|class="wikitable"
			!style="text-align: left"\| By Oral
	Clinical benefit should be assessed on a regular basis. Up to half the patients will show a slower rate of cognitive decline. Donepezil should be discontinued in those not responding.		\|nitially 5 mg once daily at bedtime, increased if necessary, after one month to max. 10 mg daily.
			Clinical benefit should be assessed on a regular basis. Up to half the patients will show a slower rate of cognitive decline. Donepezil should be discontinued in those not responding.
			\|}

	==Side Effects==		==Side Effects==

Helen at 06:13, 8 October 2020

2020-10-08T06:13:33Z

← Older revision		Revision as of 02:13, 8 October 2020
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	[[Category: Drugs]][[Category:Acetylcholinesterase inhibiting drug ]]		[[Category: Drugs]][[Category:Acetylcholinesterase inhibiting drug ]]
	Donepezil hydrochloride, is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.		'''Donepezil hydrochloride''' (中文: [[多奈哌齊]]), is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.

			==Drug Names==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名
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	\|P1S1S3		\|P1S1S3
	\|}		\|}

	==Pronunciation==		==Pronunciation==
	===Donepezil hydrochloride 10mg (ARICEPT 10mg)===		===Donepezil hydrochloride 10mg (ARICEPT 10mg)===

Ctol2: /* FAQ */

2020-09-30T09:30:55Z

FAQ

← Older revision		Revision as of 05:30, 30 September 2020
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	==FAQ==		==FAQ==

	==== How should I take the tablet?====		=== How should I take the tablet?===
	Donepezil tablet and orodispersible tablet should be taken orally at bedtime, or as directed by the doctor. The orodispersible tablet should be placed on the tongue and allowed to disperse before swallowing with or without water. Both formulations can be taken with or without food.		Donepezil tablet and orodispersible tablet should be taken orally at bedtime, or as directed by the doctor. The orodispersible tablet should be placed on the tongue and allowed to disperse before swallowing with or without water. Both formulations can be taken with or without food.

	====What should I avoid while taking?====		===What should I avoid while taking?===
	Avoid abruptly discontinue the medication.		Avoid abruptly discontinue the medication.

	==== What happen if I overdose?====		=== What happen if I overdose?===
	Contact your primary care doctor.		Contact your primary care doctor.
	If emergency situation, call 999		If emergency situation, call 999

	==== What happen if I miss a dose?====		=== What happen if I miss a dose?===
	Take it as soon as you		Take it as soon as you
	remember. If it is near the time		remember. If it is near the time

Ctol2: /* Drug Management */

2020-09-30T09:30:03Z

Drug Management

← Older revision		Revision as of 05:30, 30 September 2020
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	===Monitoring===		===Monitoring===
	*Acetylcholinesterase inhibitor may increase gastric acid secretion, so patients should be monitored closely for GI bleeding, especially those receiving concurrent NSAID drugs.		*Acetylcholinesterase inhibitor may increase gastric acid secretion, so patients should be monitored closely for GI bleeding, especially those receiving concurrent NSAID drugs.
	*~~check~~ body weight regularly		*Check body weight regularly
	*~~monitor~~ the cognitive, global functions, and ADL activities		*Monitor the cognitive, global functions, and ADL activities
	*~~monitor~~ the sleeping quality		*Monitor the sleeping quality

	===Drug interaction===		===Drug interaction===
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	\|May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions.		\|May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions.
	\|-		\|-
	!style="text-align: left"\| May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions.		!style="text-align: left"\| May increase plasma-donepezil concentration,
			increasing the risk of severe adverse reactions.
	\|May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions		\|May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions
	\|-		\|-
	!style="text-align: left"\| CYP3A4 inducers & CYP2D6 inducers:		!style="text-align: left"\| CYP3A4 inducers & CYP2D6 inducers:
	Rifampicin		Rifampicin, Phenytoin, Carbamazepine
	Phenytoin
	Carbamazepine

	\|May reduce plasma-donepezil concentration		\|May reduce plasma-donepezil concentration
	\|}		\|}

	~~'''~~Caution :		===Caution===
	*Cardiovascular conduction disorders such as sick-sinus syndrome		*Cardiovascular conduction disorders such as sick-sinus syndrome
	*Susceptibility to peptic ulcers		*Susceptibility to peptic ulcers
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	*Concomitant antipsychotic treatment – increased risk of neuroleptic malignant syndrome		*Concomitant antipsychotic treatment – increased risk of neuroleptic malignant syndrome

	~~'''~~Contraindications:		===Contraindications===
	It is contraindicated in patients with a known hypersensitivity to donepezil hydrochloride.		It is contraindicated in patients with a known hypersensitivity to donepezil hydrochloride.

	~~'''~~Hepatic and Renal impairment		===Hepatic and Renal impairment===
	A similar dose schedule can be followed for patients with renal or mild to moderate hepatic impairment as clearance of donepezil is not significantly affected by these conditions.		A similar dose schedule can be followed for patients with renal or mild to moderate hepatic impairment as clearance of donepezil is not significantly affected by these conditions.

	~~'''~~Effects on ability to drive and use machinery		===Effects on ability to drive and use machinery===
	Donepezil can cause fatigue, dizziness and muscles, mainly when initiating or increasing the dose. The treating doctor should routinely evaluate the ability of patients on donepezil to continue driving or operating complex machines.		Donepezil can cause fatigue, dizziness and muscles, mainly when initiating or increasing the dose. The treating doctor should routinely evaluate the ability of patients on donepezil to continue driving or operating complex machines.


	==FAQ==		==FAQ==

Ctol2: /* Pharmacokinetics */

2020-09-30T09:27:58Z

Pharmacokinetics

← Older revision		Revision as of 05:27, 30 September 2020
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	\|70 hours, but around 100 hours in elderly		\|70 hours, but around 100 hours in elderly
	\|-		\|-
	!Duration of action		!style="text-align: left"\| Duration of action
	\|With daily dosing, steady-state concentration is reached within 3 weeks after initiation of therapy. Once at steady-state, plasma donepezil hydrochloride concentrations show little variability over the course of the day.		\|With daily dosing, steady-state concentration is reached within 3 weeks after initiation of therapy. Once at steady-state, plasma donepezil hydrochloride concentrations show little variability over the course of the day.
	\|}		\|}

Ctol2: /* Pharmacokinetics */

2020-09-30T09:27:25Z

Pharmacokinetics

← Older revision		Revision as of 05:27, 30 September 2020
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	!style="text-align: left"\| Onset of action		!style="text-align: left"\| Onset of action
	\|Peak plasma levels in 3-4 hours		\|Peak plasma levels in 3-4 hours

	\|-		\|-
	!style="text-align: left"\| Elimination half-life		!style="text-align: left"\| Elimination half-life
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	\|}		\|}

	====How long does it take for donepezil to take effect?====		===How long does it take for donepezil to take effect?===
	Donepezil may take as long as 12 weeks to begin working.		Donepezil may take as long as 12 weeks to begin working.
	====What time of day should donepezil be taken?====		===What time of day should donepezil be taken?===
	It is usually taken once a day with or without food, just before bedtime. Take donepezil at around the same time every day.		It is usually taken once a day with or without food, just before bedtime. Take donepezil at around the same time every day.
	====Why is donepezil taken at night?====		===Why is donepezil taken at night?===
	Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects.		Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects.

Ctol2 at 09:26, 30 September 2020

2020-09-30T09:26:39Z

← Older revision		Revision as of 05:26, 30 September 2020
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	[[Category: Drugs]][[Category:Acetylcholinesterase inhibiting drug ]]		[[Category: Drugs]][[Category:Acetylcholinesterase inhibiting drug ]]
	~~==Pronunciation==~~
	~~===Donepezil hydrochloride 10mg (ARICEPT 10mg)===~~
	~~[[File:Donepezil hydrochloride 10mg (ARICEPT 10mg).mp3]]~~

	~~===Donepezil hydrochloride 5mg (ARICEPT 5mg)===~~
	~~[[File:Donepezil hydrochloride 5mg (ARICEPT 5mg).mp3]]~~

	~~==Introduction==~~

	Donepezil hydrochloride, is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.		Donepezil hydrochloride, is a reversible inhibitor of acetylcholinesterase. It is used for the treatment of mild to moderate dementia in Alzheimer’s disease.


	{\| class="wikitable"		{\| class="wikitable"
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	\|P1S1S3		\|P1S1S3
	\|}		\|}
			==Pronunciation==
			===Donepezil hydrochloride 10mg (ARICEPT 10mg)===
			[[File:Donepezil hydrochloride 10mg (ARICEPT 10mg).mp3]]

			===Donepezil hydrochloride 5mg (ARICEPT 5mg)===
			[[File:Donepezil hydrochloride 5mg (ARICEPT 5mg).mp3]]

	==Mechanism of Action==		==Mechanism of Action==
	Acetylcholinesterase inhibiting drug		Acetylcholinesterase inhibiting drug


	==Dosage==		==Dosage==

	By Oral: initially 5 mg once daily at bedtime, increased if necessary, after one month to max. 10 mg daily.		By Oral: initially 5 mg once daily at bedtime, increased if necessary, after one month to max. 10 mg daily.

	Clinical benefit should be assessed on a regular basis. Up to half the patients will show a slower rate of cognitive decline. Donepezil should be discontinued in those not responding.		Clinical benefit should be assessed on a regular basis. Up to half the patients will show a slower rate of cognitive decline. Donepezil should be discontinued in those not responding.



	==Side Effects==		==Side Effects==

	Common side effects include		Common side effects include
	*Nausea and vomiting		*Nausea and vomiting
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	==Pharmacokinetics==		==Pharmacokinetics==

	{\| class = "wikitable"		{\| class = "wikitable"
	!style="text-align: left"\| Oral bioavailability		!style="text-align: left"\| Oral bioavailability
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	====Why is donepezil taken at night?====		====Why is donepezil taken at night?====
	Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects.		Donepezil is taken at night because it can cause irregular or slow heartbeat for some patients, which can cause fainting. When it is taken at bedtime, affected patients will be able to sleep through those side effects.


	==Drug Management==		==Drug Management==
	~~'''~~Monitoring:		===Monitoring===
	*~~acetylcholinesterase~~ inhibitor may increase gastric acid secretion, so patients should be monitored closely for GI bleeding, especially those receiving concurrent NSAID drugs.		*Acetylcholinesterase inhibitor may increase gastric acid secretion, so patients should be monitored closely for GI bleeding, especially those receiving concurrent NSAID drugs.
	*check body weight regularly		*check body weight regularly
	*monitor the cognitive, global functions, and ADL activities		*monitor the cognitive, global functions, and ADL activities
	*monitor the sleeping quality		*monitor the sleeping quality

			===Drug interaction===
	~~'''~~Drug interaction:

	{\|class="wikitable"		{\|class="wikitable"
	!style="text-align: left"\| CYP2D6 inhibitors:		!style="text-align: left"\| CYP2D6 inhibitors:
	SSRI, such as Paroxetine		SSRI, such as Paroxetine quinidine
	quinidine

	\|May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions.		\|May increase plasma-donepezil concentration, increasing the risk of severe adverse reactions.
	\|-		\|-

Ctol2: /* How should I take the tablet? */

2020-09-30T09:24:49Z

How should I take the tablet?

← Older revision		Revision as of 05:24, 30 September 2020
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	==== How should I take the tablet?====		==== How should I take the tablet?====
	Donepezil tablet and orodispersible tablet should be taken orally at bedtime, or as directed by the doctor. The orodispersible tablet should be placed on the tongue and allowed to disperse before swallowing with or without water. Both formulations can be taken with or without food.		Donepezil tablet and orodispersible tablet should be taken orally at bedtime, or as directed by the doctor. The orodispersible tablet should be placed on the tongue and allowed to disperse before swallowing with or without water. Both formulations can be taken with or without food.

	====What should I avoid while taking?====		====What should I avoid while taking?====