Zeki at 08:20, 8 July 2024

2024-07-08T08:20:38Z

← Older revision		Revision as of 04:20, 8 July 2024
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	'''Edoxaban (LIXIANA)'''（中文：[[依度沙班]]）		'''Edoxaban (LIXIANA)'''（中文：[[依度沙班]]）
			==Common Strengths of Edoxaban==
			Edoxaban are available in the following strengths:
			15 mg, 30 mg, 60 mg tablets

			==Drug Trade Names of Edoxaban==
			Lixiana

			==Drug Usage==
			*Reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
			*Treatment of deep vein thrombosis (DVT) and pulmonary embolism
			*Reduce risk of recurrent DVT and PE

			==Mechanism of Action==
			Selectively inhibits factor Xa, preventing the formation of blood clots.

			==Route of Administration==
			Oral

			==Dosages==
			*60 mg once daily
			*No specific dosages for hypertension, heart failure, or diabetic kidney disease
			Renal dosing based on eGFR:
			*Mild impairment (CrCl > 50 mL/min): The recommended dose is 60 mg once daily
			*Moderate renal impairment (CrCl 30-50 mL/min): The dose should be reduced to 30 mg once daily
			*Severe renal impairment (CrCl 15-29 mL/min): The recommended dose is 30 mg once daily, but should be used with caution
			*End-stage renal disease (CrCl < 15 mL/min) or on dialysis: Not recommended

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="2" \| '''Common
			\| Easy bruising
			\|-
			\| Anemia
			\|-
			\| rowspan="2" \| '''Uncommon
			\| Abnormal liver function tests
			\|-
			\| Allergic reactions
			\|}

			==Pharmacokinetics==
			*Metabolism
			**Minimal hepatic metabolism
			*Elimination
			**50% renal excretion
			*Drug Onset
			**1 - 2 hours after oral dosing
			*Duration
			**24 hours (once-daily dosing)

			==Drug Precautions==
			'''Pregnancy

			Not recommended

			'''Breastfeeding

			Not recommended

			'''Renal Impairment

			Dose adjustment required (see renal dosing)

			'''Monitoring Requirements

			*Renal function test
			*Signs and symptoms of bleeding:
			**Unexpected bleeding or bleeding that lasts a long time
			**Unusual bruising, nosebleeds, bleeding gums
			**Pink/brown urine, red/black stools
			**Coughing up blood or blood clots
			**Vomiting blood or vomit that looks like coffee grounds

			'''Drug Interactions

			Anticoagulants, NSAIDs, antiplatelet drugs

			'''Caution

			Use with caution in patients at risk of bleeding, or taking concomitant drugs that increase risk of bleeding.

			==FAQ==
			'''How Should I Take the Tablet?

			Take with or without food, at the same time each day. It can be crushed and mixed with water if unable to be swallowed whole.

			'''What Should I Avoid While Taking?

			Activities that increase the risk of bleeding or injury

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember. Skip the missed dose if it's almost time for your next scheduled dose

Zeki: Created page with "Category: DrugsCategory: Direct Factor Xa inhibitor '''Anticoagulant Drug''' '''Drug class: :Category: Direct Factor Xa inhibit..."

2024-07-08T07:41:08Z

Created page with "Category: Drugs Category: Direct Factor Xa inhibitor '''Anticoagulant Drug''' '''Drug class: :Category: Direct Factor Xa inhibit..."

New page

[[Category: Drugs]][[Category: Direct Factor Xa inhibitor]]

[[:Category: Anticoagulant Drug | '''Anticoagulant Drug''']]

'''Drug class: [[:Category: Direct Factor Xa inhibitor | Direct Factor Xa inhibitor]]

'''Edoxaban (LIXIANA)'''（中文：[[依度沙班]]）

Edoxaban - Revision history

Zeki at 08:20, 8 July 2024

Zeki: Created page with "Category: DrugsCategory: Direct Factor Xa inhibitor '''Anticoagulant Drug''' '''Drug class: :Category: Direct Factor Xa inhibit..."