Fentanyl - Revision history

Ctol2: /* Side Effects */

2020-10-09T06:56:53Z

Side Effects

← Older revision		Revision as of 02:56, 9 October 2020
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	==Side Effects==		==Side Effects==
	===As for Opioid Analgesic in general===		===As for Opioid Analgesic in general===

	The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.		The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.

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	===Treatment of Adverse Effects===		===Treatment of Adverse Effects===

	#Constipation can be treated with laxatives such as senna tables and lactulose.		#Constipation can be treated with laxatives such as senna tables and lactulose.
	#Nausea and vomiting can be alleviated by metoclopramide.		#Nausea and vomiting can be alleviated by metoclopramide.

Ctol2: /* Mechanism of Action */

2020-10-07T07:34:26Z

Mechanism of Action

← Older revision		Revision as of 03:34, 7 October 2020
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	\|}		\|}

	~~'''~~Route of Administration~~'''~~ Fentanyl is usually given parenterally, intranasally, or by the transmucosal route as the citrate, or in transdermal patches as the base.		===Route of Administration===
			Fentanyl is usually given parenterally, intranasally, or by the transmucosal route as the citrate, or in transdermal patches as the base.

	==Dosage==		==Dosage==

Ctol2 at 07:34, 7 October 2020

2020-10-07T07:34:05Z

← Older revision		Revision as of 03:34, 7 October 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]
	'''Fentanyl''', is a potent opioid analgesic and is mainly a -opioid agonist.		'''Fentanyl''' is a potent opioid analgesic and is mainly a -opioid agonist.
	It is used as an adjunct to general anesthetics.		It is used as an adjunct to general anesthetics.

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	\|}		\|}

	'''Route of ~~Adminstration~~''' Fentanyl is usually given parenterally, intranasally, or by the transmucosal route as the citrate, or in transdermal patches as the base.		'''Route of Administration''' Fentanyl is usually given parenterally, intranasally, or by the transmucosal route as the citrate, or in transdermal patches as the base.

	==Dosage==		==Dosage==

Ctol2: /* Introduction */

2020-10-07T07:33:32Z

Introduction

← Older revision		Revision as of 03:33, 7 October 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]
	~~==Introduction==~~
	'''Fentanyl''', is a potent opioid analgesic and is mainly a -opioid agonist.		'''Fentanyl''', is a potent opioid analgesic and is mainly a -opioid agonist.
	It is used as an adjunct to general anesthetics.		It is used as an adjunct to general anesthetics.

			==Drug Names==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名

Ctol2: /* Introduction */

2020-10-07T07:32:40Z

Introduction

← Older revision		Revision as of 03:32, 7 October 2020
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	\|FENT08		\|FENT08
	\|DD		\|DD
	\|
	\|-		\|-
	\|Fentanyl patch 25 mcg/hr		\|Fentanyl patch 25 mcg/hr

Helen at 07:33, 5 October 2020

2020-10-05T07:33:00Z

← Older revision		Revision as of 03:33, 5 October 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: opioid analgesic ]]
			==Introduction==
	'''Fentanyl''', is a potent opioid analgesic and is mainly a -opioid agonist.		'''Fentanyl''', is a potent opioid analgesic and is mainly a -opioid agonist.
	It is used as an adjunct to general anesthetics.		It is used as an adjunct to general anesthetics.

Helen at 03:24, 5 October 2020

2020-10-05T03:24:02Z

← Older revision		Revision as of 23:24, 4 October 2020
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	==Side Effects==		==Side Effects==
	As for ~~'''~~Opioid Analgesic'' in general		===As for Opioid Analgesic in general===

	The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.		The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.
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	Large doses of opioids produce respiratory depression and hypotension, with circulatory failure and deepening coma. Death may occur from respiratory failure.		Large doses of opioids produce respiratory depression and hypotension, with circulatory failure and deepening coma. Death may occur from respiratory failure.

	~~'''~~Treatment of Adverse Effects~~'''~~		===Treatment of Adverse Effects===

	1. Constipation can be treated with laxatives such as senna tables and lactulose.		#Constipation can be treated with laxatives such as senna tables and lactulose.
			#Nausea and vomiting can be alleviated by metoclopramide.
	2. Nausea and vomiting can be alleviated by metoclopramide.		#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe respiratory depression and coma.

	3. Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe respiratory depression and coma.

	Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression, hypertension, application-sited reaction, appetite changes, anxiety		Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression, hypertension, application-sited reaction, appetite changes, anxiety

Helen at 02:51, 5 October 2020

2020-10-05T02:51:39Z

← Older revision		Revision as of 22:51, 4 October 2020
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	===Contraindication===		===Contraindication===
	Transdermal patch is not suitable for acute pain		Transdermal patch is not suitable for acute pain

			== FAQ ==
			=== How should I use the patch? ===
			Follow the doctor's prescription,
			Apply the patch to non-hairy skin.
			Remove from the sealed pouch, peel off the protective liner, and apply right away to the skin.
			Press firmly, making sure the contact is complete.
			=== What should I avoid while using? ===
			Do not use the patch if it appears to be broken, cut, or damaged.
			Avoid abrupt withdrawal
			=== What happen if I overdose? ===
			Emergency situation, called 999 immediately
			Antidote: Naloxone
			=== What happen if I miss a dose? ===
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take
			your next dose at the regular time. Do not double the dose to catch up.

Helen at 02:48, 5 October 2020

2020-10-05T02:48:34Z

← Older revision		Revision as of 22:48, 4 October 2020
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	\|fentanyl is mainly metabolized in the liver into the inactive metabolite		\|fentanyl is mainly metabolized in the liver into the inactive metabolite
	\|}		\|}

			==Drug Management==
			===Efficiency===
			Pain control
			===Safety===
			mental status, blood pressure, respiratory drive, and misuse / overuse.
			===Caution===
			Transdermal patch is not suitable for acute pain
			Tolerance and dependence
			===Contraindication===
			Transdermal patch is not suitable for acute pain

Helen: /* Pharmacokinetics */

2020-10-05T02:46:49Z

Pharmacokinetics

← Older revision		Revision as of 22:46, 4 October 2020
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	!Elimination half-life		!Elimination half-life
	\|It may take 17 hours or longer for plasma concentrations of fentanyl to decrease by 50% after removal of a transdermal patch; patients who have had adverse effects should be monitored for up to 24 hours.		\|It may take 17 hours or longer for plasma concentrations of fentanyl to decrease by 50% after removal of a transdermal patch; patients who have had adverse effects should be monitored for up to 24 hours.
			\|-
			!Metabolism
			\|fentanyl is mainly metabolized in the liver into the inactive metabolite
	\|}		\|}