Fludrocortisone - Revision history

Helen: /* Drug interaction */

2020-10-14T02:52:38Z

Drug interaction

← Older revision		Revision as of 22:52, 13 October 2020
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	\|-		\|-
	\|NSAIDs		\|NSAIDs
	Increased risk of gastro-intestinal bleeding		\|Increased risk of gastro-intestinal bleeding
	\|-		\|-
	\|Rifampicin		\|Rifampicin

Helen: /* Drug interaction */

2020-10-14T02:52:21Z

Drug interaction

← Older revision		Revision as of 22:52, 13 October 2020
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	\|-		\|-
	\|NSAIDs		\|NSAIDs
	Increased risk of gastro-intestinal bleeding		Increased risk of gastro-intestinal bleeding
	\|-		\|-
	\|Rifampicin		\|Rifampicin

Helen: /* Drug Management */

2020-10-14T02:52:11Z

Drug Management

← Older revision		Revision as of 22:52, 13 October 2020
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	Interactions do not generally apply to steroid used for topical action including inhalation, unless specified.		Interactions do not generally apply to steroid used for topical action including inhalation, unless specified.
	{\| class = "wikitable"		{\| class = "wikitable"
	!Drugs given with steroid		!style="text-align: left"\| Drugs given with steroid
	!Potential adverse drug interactions		!style="text-align: left"\| Potential adverse drug interactions
	\|-		\|-
	\| NSAIDs		\|NSAIDs
	\| Increased risk of gastro-intestinal bleeding		Increased risk of gastro-intestinal bleeding
	\|-		\|-
	\| Rifampicin		\|Rifampicin
	\| Accelerate metabolism of fludrocortisone so reduce its effects		\|Accelerate metabolism of fludrocortisone so reduce its effects
	\|-		\|-
	\| Antidiabetics		\|Antidiabetics
	\| Antagonize hypoglycemic effect, so may need to increase antidiabetic dosage		\|Antagonize hypoglycemic effect, so may need to increase antidiabetic dosage
	\|-		\|-
	\| Antiepileptics such as carbamazepine, phenobarbitone, phenytoin		\|Antiepileptics such as carbamazepine, phenobarbitone, phenytoin
	\| Accelerate metabolism of fludrocortisone so reduce its effects		\|Accelerate metabolism of fludrocortisone so reduce its effects
	\|-		\|-
	\| Antifungal e.g. amphotericin		\|Antifungal e.g. amphotericin
	\| Increased risk of hypokalaemia		\|Increased risk of hypokalaemia
	\|-		\|-
	\| Antiviral e.g ritonavir		\|Antiviral e.g ritonavir
	\| Increase plasma concentration of steroid – increased risk of adrenal suppression		\|Increase plasma concentration of steroid – increased risk of adrenal suppression
	\|-		\|-
	\| Digoxin		\|Digoxin
	\| Increased risk of hypokalaemia		\|Increased risk of hypokalaemia
	\|-		\|-
	\| Diuretics e.g. frusemide, hydrochlorothiazide		\|Diuretics e.g. frusemide, hydrochlorothiazide
	\| Antagonize diuretic effect; increased risk of hypokalaemia		\|Antagonize diuretic effect; increased risk of hypokalaemia
	\|-		\|-
	\| Oral contraceptive (oestrogens)		\|Oral contraceptive (oestrogens)
	\| Increase plasma concentration of steroid		\|Increase plasma concentration of steroid
	\|-		\|-
	\| Theophylline		\|Theophylline
	\| Increased risk of hypokalaemia		\|Increased risk of hypokalaemia
	\|}		\|}

Helen: /* Pharmacokinetics */

2020-10-14T02:51:25Z

Pharmacokinetics

← Older revision		Revision as of 22:51, 13 October 2020
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	== Pharmacokinetics ==		== Pharmacokinetics ==
	Fludrocortisone is readily absorbed from the gastrointestinal tract. The plasma half-life is about 3.5 hours, but fludrocortisone has a more prolonged biological half-life of 18 to 36 hours.		Fludrocortisone is readily absorbed from the gastrointestinal tract.

			The plasma half-life is about 3.5 hours, but fludrocortisone has a more prolonged biological half-life of 18 to 36 hours.

	== Drug Management ==		== Drug Management ==

Helen: /* Side Effects */

2020-10-14T02:50:34Z

Side Effects

← Older revision		Revision as of 22:50, 13 October 2020
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	Other side-effects include:		Other side-effects include:
	{\| class = "wikitable"		{\| class = "wikitable"
	!Steroid-induced diabetes		!style="text-align: left"\| Steroid-induced diabetes
	\| Raised blood sugar level		\|Raised blood sugar level
	\|-		\|-
	!Osteoporosis, muscle wasting and weakness		!style="text-align: left"\| Osteoporosis, muscle wasting and weakness
	\| Particularly danger in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae		\|Particularly danger in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae
	\|-		\|-
	! Susceptibility to infection		!style="text-align: left"\| Susceptibility to infection
	\|		\|
	\|-		\|-
	!Disturbances of the gut		!style="text-align: left"\| Disturbances of the gut
	\| Indigestion, peptic ulcer, distension of the abdomen		\|Indigestion, peptic ulcer, distension of the abdomen
	\|-		\|-
	!Suppression of growth in children		!style="text-align: left"\| Suppression of growth in children
	\|		\|
	\|-		\|-
	!Endocrine side effects		!style="text-align: left"\| Endocrine side effects
	\|Menstrual irregularities , hirsutism (increased hair growth), weight gain		\|Menstrual irregularities , hirsutism (increased hair growth), weight gain
	\|-		\|-
	!Neuropsychiatric side effects		!style="text-align: left"\| Neuropsychiatric side effects
	\| Aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, depression		\|Aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, depression
	\|-		\|-
	!Dermatological side effects		!style="text-align: left"\| Dermatological side effects
	\| Easy bruising, impaired wound healing, thinning of skin and stretch marks		\| Easy bruising, impaired wound healing, thinning of skin and stretch marks
	\|-		\|-
	!Ophthalmic side effects		!style="text-align: left"\| Ophthalmic side effects
	\| Glaucoma, partial loss of vision due to opacity in the lens of the eye (cataracts)		\|Glaucoma, partial loss of vision due to opacity in the lens of the eye (cataracts)
	\|}		\|}

Helen: /* Dosage */

2020-10-14T02:49:44Z

Dosage

← Older revision		Revision as of 22:49, 13 October 2020
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	Fludrocortisone is used, usually with hydrocortisone, for replacement therapy in adrenocortical insufficiency.		Fludrocortisone is used, usually with hydrocortisone, for replacement therapy in adrenocortical insufficiency.
	{\| class = "wikitable"		{\| class = "wikitable"
	! Replacement therapy in adrenal insufficiency		!style="text-align: left"\| Replacement therapy in adrenal insufficiency
	\| Oral: 50-300 micrograms daily		\|Oral: 50-300 micrograms daily
	\|-		\|-
	! Severe orthostatic hypotension		!style="text-align: left"\| Severe orthostatic hypotension
	\| Oral: 50-300 micrograms daily		\|Oral: 50-300 micrograms daily
	\|}		\|}

Helen: /* Drug name */

2020-10-14T02:42:23Z

Drug name

@@ Line 19: / Line 19: @@
 |FLUD01
 |P1S1S3
 |}

Helen at 02:53, 9 October 2020

2020-10-09T02:53:59Z

← Older revision		Revision as of 22:53, 8 October 2020
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	[[Category: Drugs]] [[Category: Steroids]]		[[Category: Drugs]] [[Category: Steroids]]
	'''Fludrocortisone''' is a steroid with potent mineralocorticoid activity.		'''Fludrocortisone''' (中文: [[氟可的松]])is a steroid with potent mineralocorticoid activity.
	It is used to treat:		It is used to treat:
	*Adrenocortical insufficiency		*Adrenocortical insufficiency
Line 6:		Line 6:
	*Adrenogenital syndrome		*Adrenogenital syndrome

	== ~~Introduction~~ ==		== Pronunciation ==
			=== Fludrocortisone 100mcg ===
			[[File:Fludrocortisone 100mcg.mp3]]

			==Drug name==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name		!Generic Name
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	\|fludrocortisone acetate		\|fludrocortisone acetate
	\|}		\|}

	~~== Pronunciation ==~~
	~~=== Fludrocortisone 100mcg ===~~
	~~[[File:Fludrocortisone 100mcg.mp3]]~~

	== Mechanism of Action ==		== Mechanism of Action ==

Annayung: /* Introduction */

2020-09-28T13:10:07Z

Introduction

← Older revision		Revision as of 09:10, 28 September 2020
Line 26:		Line 26:
	\|fludrocortisone acetate		\|fludrocortisone acetate
	\|}		\|}

	== Pronunciation ==		== Pronunciation ==
	=== Fludrocortisone 100mcg ===		=== Fludrocortisone 100mcg ===

Ctol2: /* Side Effects */

2020-09-08T09:58:30Z

Side Effects

← Older revision		Revision as of 05:58, 8 September 2020
Line 55:		Line 55:
	Other side-effects include:		Other side-effects include:
	{\| class = "wikitable"		{\| class = "wikitable"
	!~~steroid~~-induced diabetes		!Steroid-induced diabetes
	\| Raised blood sugar level		\| Raised blood sugar level
	\|-		\|-
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	\|		\|
	\|-		\|-
	! Disturbances of the gut		!Disturbances of the gut
	\| Indigestion, peptic ulcer, distension of the abdomen		\| Indigestion, peptic ulcer, distension of the abdomen
	\|-		\|-