Haloperidol - Revision history

Zeki at 05:31, 29 July 2024

2024-07-29T05:31:00Z

← Older revision		Revision as of 01:31, 29 July 2024
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	*IM (lactate): 2 - 5 mg every 4 - 8 hours as needed, max 20 mg/day		*IM (lactate): 2 - 5 mg every 4 - 8 hours as needed, max 20 mg/day
	*IM (decanoate):10 - 20 times daily oral dose given monthly		*IM (decanoate):10 - 20 times daily oral dose given monthly

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="9" \| '''Common
			\| Insomnia
			\|-
			\| Drowsiness and sedation
			\|-
			\| Dizziness
			\|-
			\| Dry mouth
			\|-
			\| Blurred vision
			\|-
			\| Constipation
			\|-
			\| Weight gain
			\|-
			\| Increased appetite
			\|-
			\| Urinary retention
			\|-
			\| rowspan="9" \| '''Serious
			\| Extrapyramidal symptoms (movement disorders):
			*Muscle stiffness or spasms
			*Tremors
			*Restlessness (akathisia)
			*Parkinson-like symptoms
			\|-
			\| Taradive dyskinesia (potentially irreversible involuntary movements of face and tongue)
			\|-
			\| Neuroleptic malignant syndrome (fever, muscle rigidity, altered mental state)
			\|-
			\| Low white blood cell count (agranulocytosis)
			\|-
			\| Seizures
			\|-
			\| QT prolongation leading to dangerous heart arrhythmias
			\|-
			\| Hyperprolactinemia:
			*Breast enlargement or milk production
			*Menstrual changes
			\|-
			\| Hypersensitivity reactions
			\|-
			\| Inappropriate antidiuretic hormone secretion
			\|}

			==Pharmacokinetics==
			*Metabolism: Hepatic
			*Elimination half-life: 14 to 26 hours (IV), 20.7 hours (IM), 14 to 37 hours (oral)
			*Excretion: Biliary and renal
			*Onset: 30 - 60 minutes (oral), rapid (IM/IV)
			*Duration: 24 hours or longer

			==Drug Precautions==
			'''Pregnancy

			Use only if potential benefits outweigh the risks. May cause extrapyramidal symptoms in newborns if used in the third trimester.

			'''Breastfeeding

			Use caution. Haloperidol is excreted in breast milk.

			'''Children and Elderly

			Use caution. Children may be more sensitive to side effects. Elderly patients may require lower doses and are at increased risk of adverse effects.

			'''Monitoring Requirements
			*Extrapyramidal symptoms
			*ECG in patients at risk of QT prolongation
			*Blood pressure
			*Complete blood count
			*Liver function tests

			'''Drug Interactions
			*Increased sedation with CNS depressants
			*Increased risk of arrhythmias with drugs that prolong QT interval
			*Reduced effectiveness of levodopa
			*Increased plasma levels with CYP3A4 inhibitors

			==FAQ==
			'''How Should I Take the Tablet?

			It can be taken with or without food.

			'''What should I avoid while taking?

			Avoid alcohol and activities requiring mental alertness until you know how haloperidol affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Zeki at 03:54, 29 July 2024

2024-07-29T03:54:34Z

← Older revision		Revision as of 23:54, 28 July 2024
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	'''Haloperidol (HALDOL)''' (中文:[[氟哌啶醇]])		'''Haloperidol (HALDOL)''' (中文:[[氟哌啶醇]])
			==Common Strengths of Haloperidol Tablet==
			Haloperidol are available in the following strengths:
			*Tablets: 1 mg, 1.5 mg, 5 mg, 10 mg, 20 mg
			*Oral drops: 2 mg/mL
			*Injectable solution: 5 mg/mL, 50 mg/mL and 100 mg/mL (decanoate)

			==Drug Trade Names of Haloperidol Tablet==
			*Haldol
			*Serenace

			==Drug Usage==
			*Treatment of schizophrenia and other psychoses
			*Control of tics and vocal utterances in Tourette's disorder
			*Management of agitation, delirium, and acute psychosis

			==Mechanism of Action==
			Halperidol is a potent dopamine D<sub>2</sub> receptor antagonist in the brain.

			==Route of Administration==
			*Oral (tablets and liquid)
			*Intramuscular injection
			*Intravenous injection

			==Dosages==
			For schizophrenia/psychosis in adults:
			*Oral: 0.5 - 5 mg 2 - 3 times daily, up to 30 mg/day for severe cases
			*IM (lactate): 2 - 5 mg every 4 - 8 hours as needed, max 20 mg/day
			*IM (decanoate):10 - 20 times daily oral dose given monthly

Zeki: Replaced content with "Category: DrugsCategory: Typical Antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Typical Antipsychotic |..."

2024-07-29T03:36:54Z

Replaced content with "Category: Drugs Category: Typical Antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Typical Antipsychotic |..."

Show changes

Zeki at 02:15, 25 July 2024

2024-07-25T02:15:30Z

← Older revision		Revision as of 22:15, 24 July 2024
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	[[Category: Drugs]][[Category: ~~typical antipsychotic~~ ]]		[[Category: Drugs]][[Category: Conventional Antipsychotic]]
	'''Haloperidol'''(中文:[[氟哌啶醇]]) is a typical antipsychotic medication. It is used in the treatment of various psychoses including:		'''Haloperidol'''(中文:[[氟哌啶醇]]) is a typical antipsychotic medication. It is used in the treatment of various psychoses including:
	*Schizophrenia		*Schizophrenia

Helen at 02:47, 3 November 2020

2020-11-03T02:47:52Z

← Older revision		Revision as of 22:47, 2 November 2020
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	[[Category: Drugs]][[Category: typical antipsychotic ]]		[[Category: Drugs]][[Category: typical antipsychotic ]]
	'''Haloperidol'''(中文:[[ ]]) is a typical antipsychotic medication. It is used in the treatment of various psychoses including:		'''Haloperidol'''(中文:[[氟哌啶醇]]) is a typical antipsychotic medication. It is used in the treatment of various psychoses including:
	*Schizophrenia		*Schizophrenia
	*Bipolar disorder		*Bipolar disorder

Helen at 02:17, 22 October 2020

2020-10-22T02:17:33Z

← Older revision		Revision as of 22:17, 21 October 2020
Line 1:		Line 1:
	[[Category: Drugs]][[Category: typical antipsychotic ]]		[[Category: Drugs]][[Category: typical antipsychotic ]]
	'''Haloperidol'''(中文:[[ ]]) is a typical antipsychotic medication. It is used in the treatment of various psychoses including:		'''Haloperidol'''(中文:[[ ]]) is a typical antipsychotic medication. It is used in the treatment of various psychoses including:
	*Schizophrenia		*Schizophrenia
	*Bipolar disorder		*Bipolar disorder
Line 195:		Line 195:

	==Drug Management==		==Drug Management==
	===Monitoring:===		===Monitoring===
	Baseline ECG required before treatment – assess need for further ECGs during treatment on an individual basis.		Baseline ECG required before treatment – assess need for further ECGs during treatment on an individual basis.
	During long-term use, routine monitoring includes:		During long-term use, routine monitoring includes:
Line 276:		Line 276:

	== FAQ ==		== FAQ ==
	====What should I avoid while taking?====		===What should I avoid while taking?===
	Avoid drinking alcohol while taking haloperidol because it may enhance the side effects of sedation.		Avoid drinking alcohol while taking haloperidol because it may enhance the side effects of sedation.

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	Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.		Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
	==== What happen if I overdose? ====		=== What happen if I overdose? ===
	Contact your primary care doctor.		Contact your primary care doctor.
	If emergency situation, call 999		If emergency situation, call 999
	==== What happen if I miss a dose? ====		=== What happen if I miss a dose? ===
	Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.		Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Helen at 02:50, 19 October 2020

2020-10-19T02:50:53Z

← Older revision		Revision as of 22:50, 18 October 2020
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	===Driving and skilled tasks===		===Driving and skilled tasks===
	Drivers and machine operators should be told about the risk of drowsiness with this medication especially at the start of treatment. Affected patients should not drive or operate machinery.		Drivers and machine operators should be told about the risk of drowsiness with this medication especially at the start of treatment. Affected patients should not drive or operate machinery.

			== FAQ ==
			====What should I avoid while taking?====
			Avoid drinking alcohol while taking haloperidol because it may enhance the side effects of sedation.

			Avoid driving or hazardous activity until you know how chlorpromazine will affect you.

			Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
			==== What happen if I overdose? ====
			Contact your primary care doctor.
			If emergency situation, call 999
			==== What happen if I miss a dose? ====
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Helen: /* Drug Management */

2020-10-19T02:48:28Z

Drug Management

← Older revision		Revision as of 22:48, 18 October 2020
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	===Renal impairment===		===Renal impairment===
	*Start with small doses in severe impairment because of increased cerebral sensitivity.		*Start with small doses in severe impairment because of increased cerebral sensitivity.


	===Pregnancy===		===Pregnancy===

Helen: /* Drug Management */

2020-10-19T02:48:19Z

Drug Management

← Older revision		Revision as of 22:48, 18 October 2020
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	\|An increased risk of ventricular arrhythmias – avoid concomitant use.		\|An increased risk of ventricular arrhythmias – avoid concomitant use.
	\|}		\|}

			===Caution===
			*In patient with Alzheimer’s with mild behavioral problems, its use often make their condition worse and its withdrawal is even beneficial for some cognitive and functional measures.
			*In patients with impaired liver, as haloperidol is metabolized mainly by the liver
			*Patients at special risk for the development of QT prolongation (hypokalemia, concomitant use of other drugs causing QT prolongation)
			*In those with thyrotoxicosis
			*Patients with a history of leukopenia: a complete blood count should be monitored frequently during the first few months of therapy and discontinuation of haloperidol if white blood cells

			===Contra-indications===
			Use of chlorpromazine should be avoided in individuals with:
			*CNS depression
			*Comatose states
			*Acute stroke
			*Parkinson’s disease
			*Phaeochromocytoma
			*QT-interval prolongation, when combined will tend towards cardiac arrest

			===Hepatic impairment===
			*Can precipitate coma.

			===Renal impairment===
			*Start with small doses in severe impairment because of increased cerebral sensitivity.


			===Pregnancy===
			Should be avoided in pregnancy unless the physician considers it essential.

			===Breast-feeding===
			Use during breast feeding is not recommended.

			===Driving and skilled tasks===
			Drivers and machine operators should be told about the risk of drowsiness with this medication especially at the start of treatment. Affected patients should not drive or operate machinery.

Helen: /* Drug interaction */

2020-10-19T02:45:09Z

Drug interaction

← Older revision		Revision as of 22:45, 18 October 2020
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	*Drugs metabolized by the CYP3A4 enzyme system: inducers such ass carbamazepine, phenobarbitone and rifampicin		*Drugs metabolized by the CYP3A4 enzyme system: inducers such ass carbamazepine, phenobarbitone and rifampicin
	\|		\|
	Increased risk of extrapyramidal side effects		*Increased risk of extrapyramidal side effects
			*Decreases plasma levels of haloperidol
	Decreases plasma levels of haloperidol
	\|-		\|-
	\|style="text-align: left"\|		\|style="text-align: left"\|