Hydrocortisone - Revision history

Helen: /* Drug Management */

2020-10-14T03:05:36Z

Drug Management

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	{\| class = "wikitable"		{\| class = "wikitable"
	!style="text-align: left"\| Prolonged use of steroid		!style="text-align: left"\| Prolonged use of steroid
	!~~'''~~Advice to patient		!style="text-align: left"\| Advice to patient
	\|-		\|-
	\|~~'''~~Immunosuppression		\|style="text-align: left"\| Immunosuppression
	Prolonged use can increase susceptibility to infection		Prolonged use can increase susceptibility to infection

Helen: /* Drug Management */

2020-10-14T03:05:04Z

Drug Management

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	==Drug Management==		==Drug Management==

	~~'''~~Monitoring:		===Monitoring===
	*Elderly (close supervision required particularly on long-term treatment)		*Elderly (close supervision required particularly on long-term treatment)
	*Frequent monitoring required if history of tuberculosis (or X-ray changes)		*Frequent monitoring required if history of tuberculosis (or X-ray changes)
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	*Height should be monitored in children receiving prolonged therapy with inhaled or nasal steroid.		*Height should be monitored in children receiving prolonged therapy with inhaled or nasal steroid.

	~~'''~~Drug interaction:		===Drug interaction===
	Interactions do not generally apply to steroid used for topical action including inhalation, unless specified.		Interactions do not generally apply to steroid used for topical action including inhalation, unless specified.
	{\| class = "wikitable"		{\| class = "wikitable"
	!style="text-align: left"\| Drugs given with steroid		!style="text-align: left"\| Drugs given with steroid
	!Potential adverse drug interactions		!style="text-align: left"\| Potential adverse drug interactions
	\|-		\|-
	\|NSAIDs		\|NSAIDs
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	\|}		\|}

	~~'''~~Caution:		===Caution===
	*Children and adolescents (growth restriction possibly irreversible)		*Children and adolescents (growth restriction possibly irreversible)
	*Osteoporosis (post-menopausal women at special risk)		*Osteoporosis (post-menopausal women at special risk)
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	*Myasthenia gravis		*Myasthenia gravis

	~~'''~~Contraindication:		===Contraindication===
	*acute infections		*acute infections
	*patients with active or doubtfully quiescent tuberculosis		*patients with active or doubtfully quiescent tuberculosis
	*concurrent treatment live virus vaccines for at least 3 months afterwards		*concurrent treatment live virus vaccines for at least 3 months afterwards

	~~'''~~Hepatic impairment		===Hepatic impairment===
	When steroids are administered orally or parenterally, the plasma-drug concentration may be increased in patients with hepatic impairment. The patient should be monitored closely.		When steroids are administered orally or parenterally, the plasma-drug concentration may be increased in patients with hepatic impairment. The patient should be monitored closely.

	~~'''~~Renal impairment		===Renal impairment===
	Should be used with caution in patients with renal impairment.		Should be used with caution in patients with renal impairment.

	~~'''~~Pregnancy		===Pregnancy===
	Hydrocortisone should only be used in pregnant women when benefits outweigh the risks.		Hydrocortisone should only be used in pregnant women when benefits outweigh the risks.
	*No convincing evidence that systemic steroids increase the incidence of congenital abnormalities such as cleft palate or lip.		*No convincing evidence that systemic steroids increase the incidence of congenital abnormalities such as cleft palate or lip.
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	\|Avoid contact with people who have chickenpox, shingles, or measles.		\|Avoid contact with people who have chickenpox, shingles, or measles.
	\|-		\|-
	\|~~'''~~Adrenal suppression		\|
			Adrenal suppression
	Steroid suppresses the endogenous secretion of corticotropin by the anterior pituitary, resulting the adrenal cortex becomes atrophied.		Steroid suppresses the endogenous secretion of corticotropin by the anterior pituitary, resulting the adrenal cortex becomes atrophied.
	If given for more than 3 weeks, treatment must not be stopped gradually.		If given for more than 3 weeks, treatment must not be stopped gradually.

Helen: /* Pharmacokinetics */

2020-10-14T03:03:57Z

Pharmacokinetics

← Older revision		Revision as of 23:03, 13 October 2020
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	Hydrocortisone crosses the placenta and may distributed in small amounts into breast milk.		Hydrocortisone crosses the placenta and may distributed in small amounts into breast milk.


	==Drug Management==		==Drug Management==

Helen: /* Side Effects */

2020-10-14T03:03:40Z

Side Effects

← Older revision		Revision as of 23:03, 13 October 2020
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	==Side Effects==		==Side Effects==

	Short-term use include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.		===Short-term use===
			include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.

	Long-term steroid use can lead to:		===Long-term steroid use can lead to===

	{\| class = "wikitable"		{\| class = "wikitable"
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	\|		\|
	\|-		\|-
	!\|Steroid-induced diabetes		!style="text-align: left"\| Steroid-induced diabetes
	\|		\|
	\|-		\|-
	!\|Osteoporosis, muscle wasting and weakness		!style="text-align: left"\| Osteoporosis, muscle wasting and weakness
	\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae		\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae
	\|-		\|-
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	\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia		\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia
	\|-		\|-
	!Neuropsychiatric side effects		!style="text-align: left"\| Neuropsychiatric side effects
	\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes		\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes
	\|-		\|-
	!Dermatological effects		!style="text-align: left"\| Dermatological effects
	\|easy bruising, impaired wound healing, and thinning of skin		\|easy bruising, impaired wound healing, and thinning of skin
	\|-		\|-
	!Ophthalmic effects		!style="text-align: left"\| Ophthalmic effects
	\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease		\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease
			\|}

	\|}
	Side-effects can be minimized by using lowest effective dose for minimum period possible.		Side-effects can be minimized by using lowest effective dose for minimum period possible.


	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* Dosage */

2020-10-14T03:01:13Z

Dosage

← Older revision		Revision as of 23:01, 13 October 2020
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	Hydrocortisone is used, usually with a more potent mineralocorticoid fludrocortisone, for replacement therapy in adrenocortical insufficiency.		Hydrocortisone is used, usually with a more potent mineralocorticoid fludrocortisone, for replacement therapy in adrenocortical insufficiency.

	''By Oral~~'':~~ as replacement therapy, 20-30 mg daily (usually in 2 doses, the larger in the morning and the smaller in the early evening, to mimic the circadian rhythm of the body).		{\| class="wikitable"
	''By intramuscular injection or slow intravenous injection~~'':~~ 100-500 mg, 3-4 times in 24 hours or as required.		!style="text-align: left"\| By Oral
	~~''Child dose'': as replacement therapy in adrenocortical insufficiency,~~		\|as replacement therapy, 20-30 mg daily (usually in 2 doses, the larger in the morning and the smaller in the early evening, to mimic the circadian rhythm of the body).
			\|-
	~~''By slow intravenous injection~~		!style="text-align: left"\| By intramuscular injection or slow intravenous injection
	*Up to 1 year: 25 mg		\|100-500 mg, 3-4 times in 24 hours or as required.
	*1-5 years: 50 mg		\|}
	*6-12 years: 100 mg

			{\| class="wikitable"
			!style="text-align: left"\| Child dose: as replacement therapy in adrenocortical insufficiency
			\|-
			!style="text-align: left"\| By slow intravenous injection
			\|-
			\|style="text-align: left"\| Up to 1 year: 25 mg
			\|-
			\|style="text-align: left"\| 1-5 years: 50 mg
			\|-
			\|style="text-align: left"\| 6-12 years: 100 mg
			\|}

	==Side Effects==		==Side Effects==

Helen at 02:58, 14 October 2020

2020-10-14T02:58:44Z

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	[[File:Hydrocortisone 20mg.mp3]]		[[File:Hydrocortisone 20mg.mp3]]

	~~==Drug Names==~~
	'''Equivalent anti-inflammatory doses of steroids		'''Equivalent anti-inflammatory doses of steroids
	{\| class = "wikitable"		{\| class = "wikitable"
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	\|		\|
	\| triamcinolone 4 mg		\| triamcinolone 4 mg

	\|}		\|}

			==Drug Names==
	==~~Mechanism of Action~~==

	~~Immunosuppression agent,~~
	~~Steroid replacement agent,~~
	~~Anti-inflammatory agent~~

	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名
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	\|P1S1S3		\|P1S1S3
	\|}		\|}

			==Mechanism of Action==
			Immunosuppression agent,
			Steroid replacement agent,
			Anti-inflammatory agent

	==Dosage==		==Dosage==

Helen: /* Mechanism of Action */

2020-10-14T02:57:56Z

Mechanism of Action

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	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name		!Generic Name 藥名
	藥名
	!HA Code 藥物代碼		!HA Code 藥物代碼
	!Classification藥物分類		!Classification藥物分類
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	\|HYDR06		\|HYDR06
	\|P1S1S3		\|P1S1S3

	\|}		\|}


	==Dosage==		==Dosage==

Helen at 04:16, 9 October 2020

2020-10-09T04:16:24Z

← Older revision		Revision as of 00:16, 9 October 2020
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	[[Category: Drugs]] [[Category: Steroids]]		[[Category: Drugs]] [[Category: Steroids]]
			'''Hydrocortisone''' (中文: [[氫化可的松]]) is a steroid with anti-inflammatory and immunosuppressant effects.
	~~==Pronunciation==~~
	~~===~~Hydrocortisone ~~20mg===~~
	[[~~File:Hydrocortisone 20mg.mp3~~]]


	~~== Introduction ==~~

	~~Hydrocortisone~~ is a steroid with anti-inflammatory and immunosuppressant effects.
	Indications include:		Indications include:
	*Hypersensitivity reactions e.g. anaphylaxis and angioedema		*Hypersensitivity reactions e.g. anaphylaxis and angioedema
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	Hydrocortisone can be given by mouth, topically, or by injection.		Hydrocortisone can be given by mouth, topically, or by injection.

			==Pronunciation==
			===Hydrocortisone 20mg===
			[[File:Hydrocortisone 20mg.mp3]]

			==Drug Names==
	'''Equivalent anti-inflammatory doses of steroids		'''Equivalent anti-inflammatory doses of steroids
	{\| class = "wikitable"		{\| class = "wikitable"

Helen at 07:00, 5 October 2020

2020-10-05T07:00:51Z

← Older revision		Revision as of 03:00, 5 October 2020
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	Short-term use include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.		Short-term use include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.

	Long-term steroid use can lead to:		Long-term steroid use can lead to:

Helen at 06:07, 5 October 2020

2020-10-05T06:07:09Z

← Older revision		Revision as of 02:07, 5 October 2020
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	\|Patient must mention the course of steroid when receiving treatment for intercurrent illnesses or trauma such as surgery.		\|Patient must mention the course of steroid when receiving treatment for intercurrent illnesses or trauma such as surgery.
			\|}

	== FAQ ==		== FAQ ==