Indometacin - Revision history

Helen: /* Administration in children */

2020-10-14T03:26:16Z

Administration in children

← Older revision		Revision as of 23:26, 13 October 2020
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	{\| class="wikitable"		{\| class="wikitable"
	!Aged 1 month to 17 years		!Aged 1 month to 17 years
	\|Oral :		\|Oral : 0.5 to 1 mg/kg twice daily.
	0.5 to 1 mg/kg twice daily.
	\|}		\|}

Helen: /* Administration in children */

2020-10-14T03:25:59Z

Administration in children

← Older revision		Revision as of 23:25, 13 October 2020
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	{\| class="wikitable"		{\| class="wikitable"
	!Aged 1 month to 17 years		!Aged 1 month to 17 years
	\|Oral: 0.5 to 1 mg/kg twice daily.		\|Oral :
			0.5 to 1 mg/kg twice daily.
	\|}		\|}

Helen: /* Dosage */

2020-10-14T03:25:40Z

Dosage

← Older revision		Revision as of 23:25, 13 October 2020
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	In other inflammatory eye disorders, the usual dose is 1 drop of 0.1% indomethacin eye drop 4 to 6 times daily until symptoms are resolved.		In other inflammatory eye disorders, the usual dose is 1 drop of 0.1% indomethacin eye drop 4 to 6 times daily until symptoms are resolved.

			===Administration in children===
	{\| class="wikitable"		{\| class="wikitable"
	!~~Administration in children~~		!Aged 1 month to 17 years
	\|Aged 1 month to 17 years; Oral: 0.5 to 1 mg/kg twice daily.		\|Oral: 0.5 to 1 mg/kg twice daily.
	\|}		\|}

Helen: /* Side Effects */

2020-10-14T01:38:20Z

Side Effects

← Older revision		Revision as of 21:38, 13 October 2020
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	Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.		Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.
	{\| class="wikitable"		{\| class="wikitable"
	!~~blood~~		!Blood
	\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported		\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported
	\|-		\|-
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	\|}		\|}

	Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.		Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.

	==Drug Management==		==Drug Management==

Helen at 01:37, 14 October 2020

2020-10-14T01:37:17Z

← Older revision		Revision as of 21:37, 13 October 2020
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	\|depression, drowsiness, tinnitus, confusion, insomnia, psychiatric disturbances, convulsion.		\|depression, drowsiness, tinnitus, confusion, insomnia, psychiatric disturbances, convulsion.
	\|}		\|}

	~~''Note'' : Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.~~

	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

			Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.
	{\| class="wikitable"		{\| class="wikitable"
	!blood		!blood
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	!Skin		!Skin
	\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.		\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
			\|-
			!Stomach ulcers
			\|Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.
	\|}		\|}

	Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.		Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.

	~~Cardiovascular risk~~
	Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

	~~Skin~~
	NSAIDs has been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis which can be fatal.

	==Drug Management==		==Drug Management==

Helen: /* Dosage */

2020-10-12T08:12:17Z

Dosage

← Older revision		Revision as of 04:12, 12 October 2020
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	\|}		\|}

	'''Indomethacin Eyedrops'''		'''Indomethacin Eyedrops''' :
	{\| class="wikitable"		{\| class="wikitable"
	!0.1% eye drops		!0.1% eye drops

Helen: /* Dosage */

2020-10-12T08:12:03Z

Dosage

← Older revision		Revision as of 04:12, 12 October 2020
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	\|}		\|}

	Indomethacin Eyedrops		'''Indomethacin Eyedrops'''
	{\| class="wikitable"		{\| class="wikitable"
	!0.1% eye drops		!0.1% eye drops
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	\|}		\|}


	In other inflammatory eye disorders, the usual dose is 1 drop of 0.1% indomethacin eye drop 4 to 6 times daily until symptoms are resolved.		In other inflammatory eye disorders, the usual dose is 1 drop of 0.1% indomethacin eye drop 4 to 6 times daily until symptoms are resolved.

Helen: /* Dosage */

2020-10-12T08:11:24Z

Dosage

← Older revision		Revision as of 04:11, 12 October 2020
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	\|}		\|}

	Indomethacin ~~is used as~~ 0.1% eye drops ~~to prevent~~ miosis (瞳孔縮小) during cataract surgery; the usual dose is 2 drops 3 hours before and 2 drops 1 hour before surgery.		Indomethacin Eyedrops
			{\| class="wikitable"
			!0.1% eye drops
			\|Prevent miosis (瞳孔縮小) during cataract surgery; the usual dose is 2 drops 3 hours before and 2 drops 1 hour before surgery.
			\|-
			!0.5% eye drop
			\|Prevent miosis and inflammation associated with cataract surgery

	~~A 0.5% eye drop is also available for the prevention of miosis and inflammation associated with cataract surgery.~~		\|}

	In other inflammatory eye disorders, the usual dose is 1 drop of ~~the~~ 0.1% indomethacin eye drop 4 to 6 times daily until symptoms are resolved.
			In other inflammatory eye disorders, the usual dose is 1 drop of 0.1% indomethacin eye drop 4 to 6 times daily until symptoms are resolved.

	{\| class="wikitable"		{\| class="wikitable"

Helen: /* Side Effects */

2020-10-12T08:05:32Z

Side Effects

← Older revision		Revision as of 04:05, 12 October 2020
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	\|}		\|}

	Note: Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.		''Note'' : Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.

	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.
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	\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported		\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported
	\|-		\|-
	!!Asthma		!Asthma
	\|Can be worsen		\|Can be worsen
	\|-		\|-

Helen at 08:04, 12 October 2020

2020-10-12T08:04:52Z

← Older revision		Revision as of 04:04, 12 October 2020
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	For NSAIDs in general		For NSAIDs in general
			{\| class = "wikitable"
			!style="text-align: left"\| Common side effects
			\|heartburn, nausea, dyspepsia, diarrhoea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rashes, salt and fluid retention, and high blood pressure.

	~~Common~~ side effects~~-include heartburn, nausea, dyspepsia, diarrhoea, constipation~~, ~~gastrointestinal ulceration/bleeding~~, ~~headache~~, ~~dizziness~~, ~~rashes~~, ~~salt and fluid retention~~, ~~and high blood pressure~~.		\|-
			!style="text-align: left"\| Adverse side effects
			\|depression, drowsiness, tinnitus, confusion, insomnia, psychiatric disturbances, convulsion.
			\|}

	Note: Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.		Note: Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.

	~~Other adverse effects-include depression~~, ~~drowsiness~~, ~~tinnitus, confusion, insomnia, psychiatric disturbances, convulsion~~.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

	~~Effects on the~~ blood: localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.		{\| class="wikitable"
	~~It also increases~~ the ~~risk~~ of heart attack, ~~stroke~~, ~~kidney failure~~ and ~~liver failure~~.		!blood
			\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported
			\|-
			!!Asthma
			\|Can be worsen
			\|-
			!Cardiovascular risk
			\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.
			\|-
			!Skin
			\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
			\|}

	~~NSAID can also worsen asthma~~
	Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.		Rectal irritation and bleeding have been reported occasionally in patients using indomethacin suppositories.