Irbesartan - Revision history

Zeki at 02:53, 5 September 2024

2024-09-05T02:53:38Z

← Older revision		Revision as of 22:53, 4 September 2024
Line 5:		Line 5:
	'''Drug class: [[:Category: Angiotensin II receptor Blockers ARB \| Angiotensin II Receptor Blockers, ARB]]		'''Drug class: [[:Category: Angiotensin II receptor Blockers ARB \| Angiotensin II Receptor Blockers, ARB]]

	'''Irbesartan''' (中文：[[厄貝沙坦]])		'''Irbesartan (APROVEL)''' (中文：[[厄貝沙坦]])
	==Pronunciation==		==Pronunciation==
	===Irbesartan 150mg (APROVEL 150mg)===		===Irbesartan 150mg (APROVEL 150mg)===

Zeki at 02:04, 5 September 2024

2024-09-05T02:04:19Z

← Older revision		Revision as of 22:04, 4 September 2024
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	[[Category: Drugs]][[Category:Angiotensin II receptor Blockers ARB]]		[[Category: Drugs]][[Category:Angiotensin II receptor Blockers ARB]]

	Irbesartan (中文：[[厄貝沙坦]])		[[:Category: Cardiovascular Drug \| '''Cardiovascular Drug''']]

			'''Drug class: [[:Category: Angiotensin II receptor Blockers ARB \| Angiotensin II Receptor Blockers, ARB]]

			'''Irbesartan''' (中文：[[厄貝沙坦]])
	==Pronunciation==		==Pronunciation==
	===Irbesartan 150mg (APROVEL 150mg)===		===Irbesartan 150mg (APROVEL 150mg)===

Zeki at 05:06, 21 June 2024

2024-06-21T05:06:04Z

← Older revision		Revision as of 01:06, 21 June 2024
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	[[Category: Drugs]]		[[Category: Drugs]][[Category:Angiotensin II receptor Blockers ARB]]

	Irbesartan (中文：[[厄貝沙坦]])		Irbesartan (中文：[[厄貝沙坦]])

Zeki at 04:09, 21 June 2024

2024-06-21T04:09:16Z

← Older revision		Revision as of 00:09, 21 June 2024
Line 69:		Line 69:

	==Drug Management==		==Drug Management==
			'''Pregnancy

			Should be avoided in pregnancy unless essential.

			'''Breast Feeding

			They are not recommended.

			'''Monitoring Requirements

			Monitor plasma-potassium concentration, particularly in the elderly and in patients with renal impairment.

			'''Drug Interaction
			*Diuretics
			**Enhanced hypotensive effect when given with diuretics.
			*Potassium sparing diuretics (Triamterene, Amiloride and Spironolactone) or Potassium supplement
			** Increase risk of hyperkalemia.

			'''Caution
			*Aortic or mitral valve stenosis
			*Hypertrophic cardiomyopathy
			*Patients with a history of angioedema
			*Patients with primary aldosteronism

			'''Contraindication

			The concomitant use of irbesartan with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment. (if eGFR < 60 mL/minute/1.73m<sup>2</sup>)

			==FAQs==
			'''How should I take the tablet?

			Usually take irbesartan tablet once a day.

			Your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. After the very first dose, you can take irbesartan at any time of day.

			You can take irbesartan tablet with or without food. Swallow the tablet whole with a drink of water.

			'''What should I avoid while taking?

			Avoid potassium-containing salt substitutes or potassium supplements, unless your doctor has told you to.

			'''What happens if I miss a dose?

			If you forget to take a dose and you usually take candesartan:
			*Once a day: Take it as soon as you remember unless it is less than 12 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time.
			Never take 2 doses to make up for a forgotten one.

Zeki at 03:51, 21 June 2024

2024-06-21T03:51:46Z

← Older revision		Revision as of 23:51, 20 June 2024
Line 62:		Line 62:

	==Pharmacokinetics==		==Pharmacokinetics==
			*Peak plasma concentration of irbesartan occur 1.5 to 2 hours after an oral dose.
			*Irbesartan is about 96% bound to plasma proteins.
			*It undergoes some metabolism in the liver, primarily by the cytochrome P450 isoenzyme CYP2C9, to inactive metabolites.
			*It is excreted as unchanged drug and metabolites in the bile and in urine.
			*The terminal elimination half-life is about 11 to 15 hours.

			==Drug Management==

Zeki at 03:46, 21 June 2024

2024-06-21T03:46:55Z

← Older revision		Revision as of 23:46, 20 June 2024
Line 5:		Line 5:
	===Irbesartan 150mg (APROVEL 150mg)===		===Irbesartan 150mg (APROVEL 150mg)===
	[[File:Irbesartan 150mg (APROVEL 150mg).mp3]]		[[File:Irbesartan 150mg (APROVEL 150mg).mp3]]

			==Common Strengths of Irbesartan==
			Irbesartan is available in the following strengths:
			*150 mg
			*300 mg

			==Drug Trade Names of Irbesartan==
			The brand names for irbesartan is Aprovel.

			==Mechanism of Action==
			Irbesartan is an angiotensin II receptor blocker.

			Irbesartan relaxes and widens your blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

			It is used to treat high blood pressure and heart failure. It helps to prevent future strokes, heart attacks and diabetic kidney disease.

			If you have diabetic kidney disease, it helps to protect your kidneys and slows down the disease. It reduces high blood pressure and the amount of protein you lose through your kidneys.

			==Route of Administration==
			Irbesartan is given orally as tablets.

			After a dose the hypotensive effect peaks within 3 to 6 hours and persists for at least 24 hours. The maximum hypotensive effect is achieved within 4 to 6 weeks after starting therapy.

			==Dosages==
			*For both high blood pressure and diabetic kidney disease
			**150 mg to 300 mg, taken once a day.
			*Over 75 year old, or have liver or kidney problems
			**The dose may be lower.
			**Initially 75 mg - 150 mg once a day.

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="5" \| '''Common (≥1/100 to <1/10)
			\| Musculoskeletal pain
			\|-
			\| Nausea
			\|-
			\| Vomiting
			\|-
			\| Hypotension
			\|-
			\| Hyperkalemia
			\|-
			\| rowspan="4" \| '''Very rare (<1/10,000)
			\| Dizziness
			\|-
			\| Fatigue
			\|-
			\| Cough
			\|-
			\| Hyponatremia
			\|}

			==Pharmacokinetics==

Zeki at 00:54, 21 June 2024

2024-06-21T00:54:05Z

← Older revision		Revision as of 20:54, 20 June 2024
Line 1:		Line 1:
	[[Category: Drugs~~]][[Category:~~ ]]		[[Category: Drugs]]

	Irbesartan (中文：[[厄貝沙坦]])		Irbesartan (中文：[[厄貝沙坦]])

Zeki: Replaced content with "Category: DrugsCategory: Irbesartan (中文：厄貝沙坦) ==Pronunciation== ===Irbesartan 150mg (APROVEL 150mg)=== File:Irbesartan 150mg (APROVEL 150mg)...."

2024-06-21T00:53:53Z

Replaced content with "Category: Drugs[[Category: ]] Irbesartan (中文：厄貝沙坦) ==Pronunciation== ===Irbesartan 150mg (APROVEL 150mg)=== File:Irbesartan 150mg (APROVEL 150mg)...."

← Older revision		Revision as of 20:53, 20 June 2024
Line 5:		Line 5:
	===Irbesartan 150mg (APROVEL 150mg)===		===Irbesartan 150mg (APROVEL 150mg)===
	[[File:Irbesartan 150mg (APROVEL 150mg).mp3]]		[[File:Irbesartan 150mg (APROVEL 150mg).mp3]]

	~~==Common Strengths of Irbesartan==~~
	~~Irbesartan is available in the following strengths:~~
	*150 mg
	*300 mg

	~~==Drug Trade Names of Irbesartan==~~
	~~The brand names for irbesartan is Aprovel.~~

	~~==Mechanism of Action==~~
	~~Irbesartan is an angiotensin II receptor blocker.~~

	~~Irbesartan relaxes and widens your blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.~~

	~~It is used to treat high blood pressure and heart failure. It helps to prevent future strokes, heart attacks and diabetic kidney disease.~~

	~~If you have diabetic kidney disease, it helps to protect your kidneys and slows down the disease. It reduces high blood pressure and the amount of protein you lose through your kidneys.~~

	~~==Route of Administration==~~
	~~Irbesartan is given orally as tablets.~~

	~~After a dose the hypotensive effect peaks within 3 to 6 hours and persists for at least 24 hours. The maximum hypotensive effect is achieved within 4 to 6 weeks after starting therapy.~~

	~~==Dosage==~~
	*For both high blood pressure and diabetic kidney disease
	**150 mg to 300 mg once a day
	*For over 75 years old or have liver or kidney problems
	**The dose may be lower
	**Initially 75 mg to 150 mg once a day

	~~==Side Effects==~~
	~~{\| class="wikitable"~~
	~~!style="text-align: left"\| Frequency~~
	~~!Adverse reactions~~
	\|-
	~~\| rowspan="5" \|'''Common (≥1/100 to <1/10)~~
	~~\| Musculoskeletal pain~~
	\|-
	~~\| Nausea~~
	\|-
	~~\| Vomiting~~
	\|-
	~~\| Hypotension~~
	\|-
	~~\| Hyperkalemia~~
	\|-
	~~\| rowspan="4" \|'''Very Rare (<1/10,000)~~
	~~\| Dizziness~~
	\|-
	~~\| Fatigue~~
	\|-
	~~\| Cough~~
	\|-
	~~\| Hyponatremia~~
	\|}

	~~==Pharmacokinetics==~~
	*Peak plasma concentrations of irbesartan occur 1.5 to 2 hours after an oral dose.
	*Irbesartan is about 96% bound to plasma proteins.
	*It undergoes some metabolism in the liver, primarily by the cytochrome P450 isoenzyme CYP2C9, to inactive metabolites.
	*It is excreted as unchanged drug and metabolites in the bile and in urine.
	*The terminal elimination half-life is about 11 to 15 hours.

	~~==Drug Management==~~
	~~'''Pregnancy~~

	~~Should be avoided in pregnancy unless essential.~~

	~~'''Breast Feeding~~

	~~They are not recommended.~~

	~~'''Monitoring Requirements~~

	~~Monitor plasma-potassium concentration, particularly in the elderly and in patients with renal impairment.~~

	~~'''Drug Interactions~~
	*Diuretics
	**Enhanced hypotensive effect when given with diuretics
	*Potassium sparing diuretics (triamterene, amiloride and spironolactone) or potassium supplement
	**Increase risk of hyperkalemia

	~~'''Caution~~
	*Aortic or mitral valve stenosis
	*Hypertrophic cardiomyopathy
	*Patients with a history of angioedema
	*Patients with primary aldosteronism

	~~'''Contraindication~~

	~~The concomitant use of irbesartan with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (if eGFR < 60ml/minute/1.73m2)~~

	~~==FAQs==~~
	~~'''How should I take the tablet?~~
	*Usually take irbesartan tablet once a day.
	*Your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. After the very first dose, you can take irbesartan at any time of day.
	*You can take irbesartan tablet with or without food. Swallow the tablet whole with a drink of water.

	~~'''What should I avoid while taking?~~

	~~Avoid potassium-containing salt substitutes or potassium supplements, unless your doctor has told you to.~~

	~~'''What happens if I miss a dose?~~

	~~If you forget to take a dose and you usually take candesartan:~~
	*Once a day: Take it as soon as you remember unless it is less than 12 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time
	~~Never take 2 doses to make up for a forgotten one.~~

Zeki at 00:51, 21 June 2024

2024-06-21T00:51:37Z

← Older revision		Revision as of 20:51, 20 June 2024
Line 1:		Line 1:
	[[Category: Drugs]][[Category: ~~Angiotensin II receptor Blockers ARB~~]]		[[Category: Drugs]][[Category: ]]

	Irbesartan (中文：[[厄貝沙坦]])		Irbesartan (中文：[[厄貝沙坦]])

Zeki: /* Drug Management */

2024-06-20T03:27:08Z

Drug Management

← Older revision		Revision as of 23:27, 19 June 2024
Line 73:		Line 73:
	Should be avoided in pregnancy unless essential.		Should be avoided in pregnancy unless essential.

	''''Breast Feeding		'''Breast Feeding

	They are not recommended.		They are not recommended.