Zeki at 08:36, 4 July 2024

2024-07-04T08:36:52Z

← Older revision		Revision as of 04:36, 4 July 2024
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	'''Linagliptin (TRAJENTA)'''（中文：[[利格列汀]]）		'''Linagliptin (TRAJENTA)'''（中文：[[利格列汀]]）
			==Common Strengths of Linagliptin Tablet==
			Linagliptin tablets are available in the following strengths:
			*5 mg tablets

			==Drug Trade Names of Linagliptin Tablet==
			Trajenta is the trade name for Linagliptin.

			It is also sold under various brand names when combined with other antidiabetic medications, such as:
			*GLYXAMBI TABLET 10MG/5MG: Empagliflozin 10mg + Linagliptin 5mg
			*GLYXAMBI TABLET 25MG/5MG: Empagliflozin 25mg + Linagliptin 5mg
			*TRAJENTA DUO TABLET 2.5/1000MG: Linagliptin 2.5mg + Metformin 1000mg
			*TRAJENTA DUO TABLET 2.5/850MG: Linagliptin 2.5mg + Metformin 850mg
			*TRAJENTA DUO TABLET 2.5/500MG: Linagliptin 2.5mg + Metformin 500mg

			==Drug Usage==
			Treatment of type 2 diabetes mellitus in adults, as an adjunct to diet and exercise.

			==Mechanism of Action==
			Inhibits DPP-4 enzyme, increasing levels of incretin hormones (GLP-1 and GIP) which stimulate insulin release and decrease glucagon secretion, thereby lowering blood glucose.

			==Route of Administration==
			Oral

			==Dosages==
			*5 mg once daily
			*No dose adjustment needed for hypertension, heart failure or diabetic kidney disease

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="3" \| '''Common
			\| Upper respiratory tract infection
			\|-
			\| Nasopharyngitis
			\|-
			\| Headache
			\|-
			\| rowspan="6" \| '''Uncommon
			\| Hypoglycemia
			\|-
			\| Cough
			\|-
			\| Rash
			\|-
			\| Pancreatitis
			\|-
			\| Angioedema
			\|-
			\| Stevens-Johnson syndrome
			\|}

			==Pharmacokinetics==
			*Absorption
			**Rapidly absorbed, 30% bioavailable. Maximum inhibition of DPP-4 activity is seen 30 minutes after a linagliptin dose
			*Distribution
			**75 - 99% protein bound
			*Metabolism
			**Minimal metabolism
			*Elimination
			**Primarily excreted unchanged in feces (80%) and urine (5%), half-life ~12 hours
			Linagliptin begins to work within 30 - 60 minutes of administration, with peak effects occurring around 1.5 - 2 hours after taking the dose. Linagliptin provides >80% inhibition of DPP-4 up to 24 hours.

			==Drug Precautions==
			'''Pregnancy

			Not recommended, limited data available

			'''Breastfeeding

			Not recommended

			'''Children and Elderly
			*Children: Safety and efficacy not established in <18 years
			*Elderly: No dose adjustment required based on age

			'''Renal Impairment

			No dose adjustment required

			'''Monitoring Requirements
			*Blood glucose
			*HbA1c
			*Signs of pancreatitis
			The main symptoms of pancreatitis include:
			*Severe abdominal pain, typically in the upper abdomen, that may:
			**Feel worse after eating
			**Be sudden and intense in acute cases
			*Nausea and vomiting
			*Fever
			*Rapid pulse/heart rate

			'''Drug interactions

			May increase risk of hypoglycemia when used with insulin or sulfonylureas

			==FAQ==
			'''How Should I Take the Tablet?

			Take 5 mg once daily with or without food

			'''What Should I Avoid While Taking?

			Alcohol (may increase risk of hypoglycemia)

			'''What Happens if I Miss a Dose?

			Take as soon as remembered unless close to next dose, do not double dose

Zeki: Created page with "Category: DrugsCategory: Dipeptidyl peptidase-4 (DPP-4) inhibitor '''Antidiabetic Drug''' '''Drug class: :Category: Dipeptidyl p..."

2024-07-04T08:27:13Z

Created page with "Category: Drugs Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor '''Antidiabetic Drug''' '''Drug class: :Category: Dipeptidyl p..."

New page

[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

[[:Category: Antidiabetic Drug | '''Antidiabetic Drug''']]

'''Drug class: [[:Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor | Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

'''Linagliptin (TRAJENTA)'''（中文：[[利格列汀]]）

Linagliptin - Revision history

Zeki at 08:36, 4 July 2024

Zeki: Created page with "Category: DrugsCategory: Dipeptidyl peptidase-4 (DPP-4) inhibitor '''Antidiabetic Drug''' '''Drug class: :Category: Dipeptidyl p..."