Lisinopril - Revision history

Zeki: /* Drug Management */

2024-09-23T01:11:34Z

Drug Management

← Older revision		Revision as of 21:11, 22 September 2024
Line 130:		Line 130:

	'''Renal Impairment		'''Renal Impairment
	*If eGFR 31-80 mL/minute/1.73 m2		*If eGFR 31-80 mL/minute/1.73 m<sup>2</sup>
	**Max. initial doses 5-10 mg daily. (max. 40 mg daily)		**Max. initial doses 5-10 mg daily. (max. 40 mg daily)
	*If eGFR 10-30 mL/minute/1.73 m2		*If eGFR 10-30 mL/minute/1.73 m<sup>2</sup>
	**2.5 – 5 mg daily (max. 40 mg daily)		**2.5 – 5 mg daily (max. 40 mg daily)
	*If eGFR < 10 mL/minute/1.73 m2		*If eGFR < 10 mL/minute/1.73 m<sup>2</sup>
	**2.5 mg daily		**2.5 mg daily

Zeki: /* Pharmacokinetics */

2024-09-09T07:10:17Z

Pharmacokinetics

← Older revision		Revision as of 03:10, 9 September 2024
Line 111:		Line 111:
	*The clearance of lisinopril in healthy subjects is approximately 50 mL/min.		*The clearance of lisinopril in healthy subjects is approximately 50 mL/min.

	'''Renal ~~impairment~~		'''Renal Impairment

	Impaired renal function decreases elimination of lisinopril, which is excreted via the kidneys, but this decrease becomes clinically important only when the glomerular filtration rate is below 30 mL/min.		Impaired renal function decreases elimination of lisinopril, which is excreted via the kidneys, but this decrease becomes clinically important only when the glomerular filtration rate is below 30 mL/min.

Zeki at 07:09, 9 September 2024

2024-09-09T07:09:47Z

← Older revision		Revision as of 03:09, 9 September 2024
Line 5:		Line 5:
	'''Drug class: [[:Category: ACE inhibitors \| Angiotensin Converting Enzyme Inhibitors, ACEI]]		'''Drug class: [[:Category: ACE inhibitors \| Angiotensin Converting Enzyme Inhibitors, ACEI]]

	'''Lisinopril (ZESTRIL)''' ~~(中文~~: [[賴諾普利]])		'''Lisinopril (ZESTRIL)'''（中文: [[賴諾普利]]）
	==Pronunciation==		==Pronunciation==
	===Lisinopril 10mg===		===Lisinopril 10mg===

Zeki at 02:49, 5 September 2024

2024-09-05T02:49:19Z

← Older revision		Revision as of 22:49, 4 September 2024
Line 5:		Line 5:
	'''Drug class: [[:Category: ACE inhibitors \| Angiotensin Converting Enzyme Inhibitors, ACEI]]		'''Drug class: [[:Category: ACE inhibitors \| Angiotensin Converting Enzyme Inhibitors, ACEI]]

	'''Lisinopril''' (中文: [[賴諾普利]])		'''Lisinopril (ZESTRIL)''' (中文: [[賴諾普利]])
	==Pronunciation==		==Pronunciation==
	===Lisinopril 10mg===		===Lisinopril 10mg===

Zeki at 01:42, 5 September 2024

2024-09-05T01:42:47Z

← Older revision		Revision as of 21:42, 4 September 2024
Line 1:		Line 1:
	[[Category: Drugs]][[Category: ACE inhibitors]]		[[Category: Drugs]][[Category: ACE inhibitors]]

			[[:Category: Cardiovascular Drug \| '''Cardiovascular Drug''']]

			'''Drug class: [[:Category: ACE inhibitors \| Angiotensin Converting Enzyme Inhibitors, ACEI]]

	'''Lisinopril''' (中文: [[賴諾普利]])		'''Lisinopril''' (中文: [[賴諾普利]])

Helen: /* Mechanism of Action */

2024-06-21T01:34:27Z

Mechanism of Action

← Older revision		Revision as of 21:34, 20 June 2024
Line 22:		Line 22:

	==Mechanism of Action ==		==Mechanism of Action ==
	Lisinopril is an angiotensin converting enzyme inhibitor.		Lisinopril is an angiotensin-1 converting enzyme (ACE inhibitor).

	The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system.		The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system.
Line 29:		Line 29:

	Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration.		Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration.
	Lisinopril is used in the treatment of hypertension and heart failure. It also improves your survival if you are taking it after a recent heart attack of ~~for~~ heart failure.		Lisinopril is used in the treatment of hypertension and heart failure. It also improves your survival if you are taking it after a recent heart attack of heart failure.

	It works by widening your blood vessels and making it easier for your heart to pump blood around your body. It can also be used for diabetic kidney disease, to slow down the disease.		It works by widening your blood vessels and making it easier for your heart to pump blood around your body. It can also be used for diabetic kidney disease, to slow down the disease.

	==Route of Administration==		==Route of Administration==

Zeki at 06:27, 14 June 2024

2024-06-14T06:27:53Z

← Older revision		Revision as of 02:27, 14 June 2024
Line 101:		Line 101:

	==Pharmacokinetics==		==Pharmacokinetics==
	Following oral administration of lisinopril, peak serum concentrations occur within about 7 hours, although there was a trend to a small delay in time taken to reach peak serum concentrations in acute myocardial infarction patients. Lisinopril absorption is not affected by the presence of food.		*Following oral administration of lisinopril, peak serum concentrations occur within about 7 hours, although there was a trend to a small delay in time taken to reach peak serum concentrations in acute myocardial infarction patients.
	Lisinopril does not undergo metabolism and is excreted entirely unchanged into the urine. On multiple dosing lisinopril has an effective half-life of 12.6 hours. The clearance of lisinopril in healthy subjects is approximately 50 ml/min.		*Lisinopril absorption is not affected by the presence of food.
			*Lisinopril does not undergo metabolism and is excreted entirely unchanged into the urine.
			*On multiple dosing lisinopril has an effective half-life of 12.6 hours.
			*The clearance of lisinopril in healthy subjects is approximately 50 mL/min.

	~~<u>~~Renal impairment~~</u>~~		'''Renal impairment

	Impaired renal function decreases elimination of lisinopril, which is excreted via the kidneys, but this decrease becomes clinically important only when the glomerular filtration rate is below 30 ml/min.		Impaired renal function decreases elimination of lisinopril, which is excreted via the kidneys, but this decrease becomes clinically important only when the glomerular filtration rate is below 30 mL/min.

	~~Efficiency:~~		==Drug Management==
			'''Safety

	~~Safety:~~ Your very first dose may make you feel dizzy, so it is best to take it at bedtime. After the first dose, if you do not feel dizzy, you can take lisinopril at any time of day. Try to take it at the same time every day.		Your very first dose may make you feel dizzy, so it is best to take it at bedtime. After the first dose, if you do not feel dizzy, you can take lisinopril at any time of day. Try to take it at the same time every day.

	~~PREGNANCY should be avoided in pregnancy unless essential.~~		'''Pregnancy

	~~BREAST FEEDING avoid in the few weeks after delivery, particularly in preterm infants – risk of profound neonatal hypotension; can~~ be ~~used~~ in ~~mothers breast-feeding older infants if~~ essential.		Should be avoided in pregnancy unless essential.

	~~RENAL IMPAIRMENT~~		'''Breast Feeding
			*Should avoid in the few weeks after delivery, particularly in preterm infants
			**risk of profound neonatal hypotension
			*Can be used in mothers breast-feeding older infants if essential.

	Max. initial doses 5-10 mg daily if eGFR 31-~~80 ml~~/minute/1.73 m2 (max. ~~40mg~~ daily)		'''Renal Impairment
			*If eGFR 31-80 mL/minute/1.73 m2
			**Max. initial doses 5-10 mg daily. (max. 40 mg daily)
			*If eGFR 10-30 mL/minute/1.73 m2
			**2.5 – 5 mg daily (max. 40 mg daily)
			*If eGFR < 10 mL/minute/1.73 m2
			**2.5 mg daily

	~~2.5 – 5 mg daily if eGFR 10-30 ml/minute/1.73 m2 (max. 40 mg daily)~~		'''Monitoring Requirements

	~~2.5 mg daily if eGFR < 10 ml/minute/1.73 m2~~


	~~MONITORING REQUIREMENTS~~

	Renal function and electrolytes should be checked before starting ACE inhibitors (or increasing the dose) and monitored during treatment (more frequently if side effects mentioned are present).		Renal function and electrolytes should be checked before starting ACE inhibitors (or increasing the dose) and monitored during treatment (more frequently if side effects mentioned are present).

			'''Drug Interactions
			*Diuretics
			**Prior treatment with high dose diuretics may result in volume depletion and a risk of hypotension when initiating therapy with Lisinopril.
			*Potassium sparing diuretics (triamterene, amiloride and spironolactone) or potassium supplement
			**May cause significant increase in serum potassium.

	~~Drug Interaction:~~		'''Caution
			*Concomitant diuretics
	~~'''Diuretics''': prior treatment with high dose diuretics may result in volume depletion and a risk of hypotension when initiating therapy with Lisinopril.~~		**First dose hypotension (especially in patients taking high doses of diuretics, on a low-sodium diet, on dialysis, dehydrated , or with heart failure)

	'''~~Potassium sparing diuretics''' (triamterene, amiloride and spironolactone) '''or potassium supplement''': may cause significant increase in serum potassium.~~


	Caution:
	* Concomitant diuretics ~~– first~~ dose hypotension (especially in patients taking high doses of diuretics, on a low-sodium diet, on dialysis, dehydrated , or with heart failure)
	*Use with care in those with a history of angioedema		*Use with care in those with a history of angioedema
	*Use with care in patients with severe or symptomatic aortic stenosis (risk of hypotension)		*Use with care in patients with severe or symptomatic aortic stenosis (risk of hypotension)

	== ~~FAQ~~ ==		==FAQs==
	~~====~~ How should I take the tablet? ~~====~~		'''How should I take the tablet?

	Your doctor may advise you to take your first dose before bedtime, because it can make you dizzy. After the first dose, if you do not feel dizzy, you can take the tablet at any time of day. Try to take it at the same time every day.		Your doctor may advise you to take your first dose before bedtime, because it can make you dizzy. After the first dose, if you do not feel dizzy, you can take the tablet at any time of day. Try to take it at the same time every day.
	You can take lisinopril with or without food. Swallow the tablet whole with a drink of water.		You can take lisinopril with or without food. Swallow the tablet whole with a drink of water.

	~~====~~ What should I avoid while taking? ~~====~~		'''What should I avoid while taking?
	Should avoid potassium rich foods: lisinopril has the capacity to increase potassium level in the blood. High levels of potassium can lead to irregular heartbeat. It is better to avoid potassium-rich foods like bananas.
			Should avoid potassium rich foods as lisinopril has the capacity to increase potassium level in the blood. High levels of potassium can lead to irregular heartbeat. It is better to avoid potassium-rich foods like bananas.

			'''What happens if I miss a dose?

	~~====What happen if I miss a dose?====~~
	If you forget to take a dose and you usually take lisinopril		If you forget to take a dose and you usually take lisinopril
	*Once a day ~~– take~~ it as soon as you remember unless it is less than 12 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time		*Once a day: Take it as soon as you remember unless it is less than 12 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time
	Never take 2 doses to make up for a forgotten one.		Never take 2 doses to make up for a forgotten one.

Zeki at 05:46, 14 June 2024

2024-06-14T05:46:08Z

← Older revision		Revision as of 01:46, 14 June 2024
Line 49:		Line 49:

	==Side Effects==		==Side Effects==
	~~The following definitions of frequencies are used:~~

	~~Very common ≥ 1/10~~

	~~Common ≥ 1/100 to < 1/10~~

	~~Uncommon ≥ 1/1,000 to < 1/100~~

	~~Rare ≥ 1/10,000 to < 1/1,000~~

	~~Very rare < 1/10,000~~

	{\| class="wikitable"		{\| class="wikitable"
	!style="text-align: left"\| ~~System Organ Class~~		!style="text-align: left"\| Frequency
	!Frequency
	!Adverse reactions		!Adverse reactions
	\|-		\|-
	\| rowspan="2" \| '''~~Nervous system disorders~~		\| rowspan="8" \|'''Common (≥1/100 to <1/10)
	\|Common		\| Dizziness
	\|Dizziness~~, headache,~~
	\|-		\|-
	\|~~Uncommon~~		\| Headache
	~~\|Confusion, sleep disturbances~~
	\|-		\|-
	~~\|'''Respiratory disorders~~		\| Dry
	~~\|Common~~
	\|Dry~~, itickly (non-productive) cough, dyspnoea~~
	\|-		\|-
	\| ~~rowspan="2" \|'''Skin disorders~~		\| Itickly (non-productive) cough
	~~\|Uncommon~~
	~~\|Itching or a mild skin rash~~
	\|-		\|-
	\|~~rare~~		\| Dyspnoea
	~~\|Alopecia, oedema of the face, extremities, lips, tongue, glottis, and/or larynx~~
	\|-		\|-
	\| ~~rowspan="4" \|'''Gastro-intestinal disorders~~		\| Vomiting
	~~\|Common~~
	~~\|vomiting, diarrhoea~~
	\|-		\|-
	\|~~Uncommon~~		\| Diarrhoa
	~~\|Nausea, abdominal pain and indigestion~~
	\|-		\|-
	\|~~Rare~~		\| Hypotension
	~~\|Dry mouth~~
	\|-		\|-
	\|~~Very rare~~		\| rowspan="8" \|'''Uncommon (≥1/1,000 to <1/100)
	\|~~Glossitis, pancreatitis~~		\| Confusion
	\|-		\|-
	\|~~'''Cardiac disorders~~		\| Sleep disturbances
	~~\|UnCommon~~
	~~\|Palpitations, tachycardia~~
	\|-		\|-
	\| ~~rowspan="2" \|'''Vascular disorder~~		\| Itching or a mild skin rash
	~~\|common~~
	~~\|Hypotension~~
	\|-		\|-
	\|~~Uncommon~~		\| Nausea
	\|~~Raynaud’s~~ syndrome		\|-
			\| Abdominal pain and indigestion
			\|-
			\| Palpitations
			\|-
			\| Tachycardia
			\|-
			\| Raynaud's syndrome
			\|-
			\| rowspan="3" \| '''Rare (≥1/10,000 to <1/1,000)
			\| Alopecia
			\|-
			\| Oedema of the face, extremities, lips, tongue, glottis and/or larynx
			\|-
			\| Dry mouth
			\|-
			\| rowspan="2" \| '''Very Rare (<1/10,000)
			\| Glossitis
			\|-
			\| Pancreatitis
	\|}		\|}

Zeki at 05:26, 14 June 2024

2024-06-14T05:26:15Z

← Older revision		Revision as of 01:26, 14 June 2024
Line 1:		Line 1:
	[[Category: Drugs]][[Category: ACE inhibitors]]		[[Category: Drugs]][[Category: ACE inhibitors]]

	'''Lisinopril''' (中文:[[賴諾普利]]) ~~is an inhibitor of angiotensin-I converting enzyme (ACE inhibitor).~~		'''Lisinopril''' (中文: [[賴諾普利]])

	==Pronunciation==		==Pronunciation==
	===Lisinopril 10mg===		===Lisinopril 10mg===
Line 13:		Line 12:
	[[File:Lisinopril 5mg.mp3]]		[[File:Lisinopril 5mg.mp3]]

	~~{\| class~~=~~"wikitable"~~		==Common Strengths of Lisinopril==
	~~!style~~=~~"text-align: left"\| Generic Name:~~		Lisinopril is available in the following strengths:
	\|Lisinopril		*5 mg
	\|-		*10 mg
	~~!style~~=~~"text-align: left"\| Class:~~		*20 mg
	~~\|Cardiovascular Drug~~
	\|-
	~~!style="text-align: left"\| Subclass~~:
	~~\|ACE inhibitors~~
	\|-
	~~!style="text-align: left"\| Legal Classification:~~
	~~\|P1S1S3~~
	\|}

	==Drug Names==		==Drug Trade Names of Lisinopril==
	~~{\| class="wikitable"~~		The brand names for lisinopril is Zestril.
	~~!Generic Name 藥物化學名稱~~
	~~!HA Code 藥物代碼~~
	~~!Legal Classification法律藥物分類~~
	~~!Brand Name 藥名~~
	\|-
	~~\| Lisinorpil Tablet 5mg~~
	~~\| LISI01~~
	~~\| P1S1S3~~
	~~\| rowspan="3" \| ZESTRIL~~
	\|-
	~~\| Lisinorpil Tablet 10mg~~
	~~\| LISI02~~
	~~\| P1S1S3~~
	\|-
	~~\|Lisinorpil Tablet 20mg~~
	~~\|LISI03~~
	~~\|P1S1S~~
	\|}

	==Mechanism of Action ==		==Mechanism of Action ==
			Lisinopril is an angiotensin converting enzyme inhibitor.

	The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system.		The beneficial effects of ACE inhibitors appear to result primarily from the suppression of the plasma renin-angiotensin-aldosterone system.

	Renin is synthesized by the kidneys and released into the circulation where it converts angiotensinogen to angiotensin-I. Angiotensin-I is then converted by angiotensin converting enzyme to angiotensin-II. Angiotensin-II is a potent vasoconstrictor responsible for arterial vasoconstriction and increased blood pressure, as well as for stimulation of the adrenal gland to secrete aldosterone.		Renin is synthesized by the kidneys and released into the circulation where it converts angiotensinogen to angiotensin-I. Angiotensin-I is then converted by angiotensin converting enzyme to angiotensin-II. Angiotensin-II is a potent vasoconstrictor responsible for arterial vasoconstriction and increased blood pressure, as well as for stimulation of the adrenal gland to secrete aldosterone.

	Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration.		Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. The latter decrease may result in an increase in serum potassium concentration.
	Lisinopril is used in the treatment of hypertension and heart failure. It also improves your survival if you are taking it after a recent heart attack of for heart failure.		Lisinopril is used in the treatment of hypertension and heart failure. It also improves your survival if you are taking it after a recent heart attack of for heart failure.
	~~It works by widening your blood vessels and making it easier for your heart to pump blood around your body. It can also be used for diabetic kidney disease, to slow down the disease.~~

	~~Lisinopril comes as tablet~~.		It works by widening your blood vessels and making it easier for your heart to pump blood around your body. It can also be used for diabetic kidney disease, to slow down the disease.

	== Route of Administration ==		==Route of Administration==
	Lisinopril is administered orally in a single daily dose. The absorption of Lisinopril tablet is not affected by food.		Lisinopril is administered orally in a single daily dose. The absorption of Lisinopril tablet is not affected by food.

	==Dosage==		==Dosage==
	~~'''~~Hypertension		*Hypertension
			**Adult: Initially 10 mg once daily; maintenance 20 mg once daily; maximum 80 mg/day.
	Adult: ~~initially~~ 10 mg once daily; maintenance 20 mg once daily; maximum 80 mg/day.		*Heart failure
			**Adult: Initially 2.5 mg once daily, increased in steps of up to 10 mg at least every 2 weeks; maximum 35 mg per day if tolerated.
	~~'''~~Heart failure		*Diabetic kidney disease
			**10 mg to 20 mg once daily
	Adult: ~~initially~~ 2.5 mg once daily, increased in steps of up to 10 mg at least every 2 weeks; maximum 35 mg per day if tolerated.

	~~'''~~Diabetic kidney disease~~'''~~ 10 mg to 20 mg once daily

	The antihypertensive effects of lisinopril are seen within 1 to 2 hours of a single oral dose and the maximum effect occurs after about 6 hours, although the full effect may not develop for several weeks during chronic dosing.		The antihypertensive effects of lisinopril are seen within 1 to 2 hours of a single oral dose and the maximum effect occurs after about 6 hours, although the full effect may not develop for several weeks during chronic dosing.

Helen: /* Pharmacokinetics */

2022-08-24T03:08:27Z

Pharmacokinetics

← Older revision		Revision as of 23:08, 23 August 2022
Line 164:		Line 164:

	Renal function and electrolytes should be checked before starting ACE inhibitors (or increasing the dose) and monitored during treatment (more frequently if side effects mentioned are present).		Renal function and electrolytes should be checked before starting ACE inhibitors (or increasing the dose) and monitored during treatment (more frequently if side effects mentioned are present).


	Drug Interaction:		Drug Interaction:
Line 170:		Line 171:

	'''Potassium sparing diuretics''' (triamterene, amiloride and spironolactone) '''or potassium supplement''': may cause significant increase in serum potassium.		'''Potassium sparing diuretics''' (triamterene, amiloride and spironolactone) '''or potassium supplement''': may cause significant increase in serum potassium.


	Caution:		Caution: