Meloxicam - Revision history

Helen at 03:50, 14 October 2020

2020-10-14T03:50:31Z

← Older revision		Revision as of 23:50, 13 October 2020
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	==Side Effects==		==Side Effects==
			NSAIDs in general
	~~===~~NSAIDs in general===		{\| class = "wikitable"
			!style="text-align: left"\| Common side effects
	~~Meloxicam can result in~~ gastrointestinal toxicity and bleeding, headaches, rash and very dark or black stool (a sign of intestinal bleeding). Like other NSAIDs, its use is associated with an increased risk of cardiovascular events such as heart attack and stroke.		\|gastrointestinal toxicity and bleeding, headaches, rash and very dark or black stool (a sign of intestinal bleeding). Like other NSAIDs, its use is associated with an increased risk of cardiovascular events such as heart attack and stroke.

	A systematic review has found that It has fewer gastrointestinal side effects with meloxicam 7.5 mg daily when compared with diclofenac (100 or 150 mg daily), naproxen (500 mg twice daily), or piroxicam (20 mg daily) which are not COX-2 selective.		A systematic review has found that It has fewer gastrointestinal side effects with meloxicam 7.5 mg daily when compared with diclofenac (100 or 150 mg daily), naproxen (500 mg twice daily), or piroxicam (20 mg daily) which are not COX-2 selective.
			\|-
	~~Other adverse~~ effects ~~include~~ depression, drowsiness, tinnitus, confusion, insomnia, psychiatric disturbances, convulsion.		!style="text-align: left"\| Adverse side effects
			\|depression, drowsiness, tinnitus, confusion, insomnia, psychiatric disturbances, convulsion.
	~~Effects on the blood: localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.~~		\|}

	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.
			{\| class="wikitable"
	~~NSAID can also worsen asthma~~.		!Asthma
			\|Can be worsened
	~~===~~Cardiovascular risk~~===~~		\|-
	Chronic use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.		!Effects on blood
			\|Localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.
	~~===~~Skin~~===~~		\|-
	NSAIDs ~~has~~ been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis which can be fatal.		!Geriatrics
			\|Use of meloxicam is not recommended in people with peptic ulcer disease or increased gastrointestinal bleed risk, including those over 75 years of age, or those taking medications associated with bleeding risk. Adverse events have been found to be dose-dependent and associated with length of treatment.
	~~===Geriatrics===~~		\|-
	Use of meloxicam is not recommended in people with peptic ulcer disease or increased gastrointestinal bleed risk, including those over 75 years of age, or those taking medications associated with bleeding risk. Adverse events have been found to be dose-dependent and associated with length of treatment.		!Cardiovascular risk
			\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.
			\|-
			!Skin
			\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
			\|}

	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* Dosage */

2020-10-14T03:38:43Z

Dosage

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	!Acute exacerbations of osteoarthritis		!Acute exacerbations of osteoarthritis
	\|Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.		\|Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.
			\|-
			!Renal impairment
			\|Meloxicam is contra-indicated in patients with severe renal impairment.
			However, in dialyzed patients, meloxicam may be given in a dose of 7.5 mg daily orally or rectally as suppositories. No dose reduction is required in those with mild to moderate renal impairment (creatinine clearance of greater than 25 mL/min).
	\|}		\|}
	~~===In the treatment of rheumatoid arthritis and ankylosing spondylitis===~~
	~~Oral: 15 mg daily as a single dose.~~
	~~hose with an increased risk of adverse reactions should be started on 7.5 mg daily. A dose of 7.5 mg daily is recommended for long-term treatment in the elderly.~~

	~~===In the treatment of acute exacerbations of osteoarthritis===~~
	~~Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.~~

	===Administration in children===		===Administration in children===
	BNFC has suggested the following oral doses, according to body-weight, for the relief of pain and inflammation in juvenile idiopathic arthritis and other musculoskeletal disorders in children aged 12 to 17 years who are intolerant of other NSAIDs:		BNFC has suggested the following oral doses, according to body-weight, for the relief of pain and inflammation in juvenile idiopathic arthritis and other musculoskeletal disorders in children aged 12 to 17 years who are intolerant of other NSAIDs:
	*Less than 50 kg: 7.5 ~~mg once daily~~		{\| class="wikitable"
	*50 kg and over: 15 mg once daily		\|Less than 50 kg
			\|7.5 mg once daily

	~~===Administration in renal impairment===~~		\|-
	~~Meloxicam is contra-indicated in patients with severe renal impairment.~~		\|50 kg and over
	~~However, in dialyzed patients, meloxicam may be given in a dose of 7.5~~ mg daily ~~orally or rectally as suppositories. No dose reduction is required in those with mild to moderate renal impairment (creatinine clearance of greater than 25 mL/min).~~		\|15 mg once daily
			\|}

	==Side Effects==		==Side Effects==

Helen: /* Dosage */

2020-10-14T03:35:44Z

Dosage

← Older revision		Revision as of 23:35, 13 October 2020
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	==Dosage==		==Dosage==
	It is used by mouth or by injection into a vein. It is recommended that it be used for as short a period as possible and at a low dose.		It is used by mouth or by injection into a vein. It is recommended that it be used for as short a period as possible and at a low dose.
			{\| class="wikitable"
			!Rheumatoid arthritis/ankylosing spondylitis
			\|Oral: 15 mg daily as a single dose.

			Those with an increased risk of adverse reactions should be started on 7.5 mg daily. A dose of 7.5 mg daily is recommended for long-term treatment in the elderly.
			\|-
			!Acute exacerbations of osteoarthritis
			\|Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.
			\|}
	===In the treatment of rheumatoid arthritis and ankylosing spondylitis===		===In the treatment of rheumatoid arthritis and ankylosing spondylitis===
	Oral: 15 mg daily as a single dose.		Oral: 15 mg daily as a single dose.

Helen: /* Drug name */

2020-10-14T03:31:31Z

Drug name

← Older revision		Revision as of 23:31, 13 October 2020
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	\|-		\|-
	\|Meloxicam Tablet 15 mg		\|Meloxicam Tablet 15 mg
	\|		\|n/a
	\|P1S1S3		\|P1S1S3
	\|}		\|}

	==Mechanism of Action==		==Mechanism of Action==
	Non-opioid Analgesic (NSAID)		Non-opioid Analgesic (NSAID)

Helen at 03:02, 12 October 2020

2020-10-12T03:02:17Z

← Older revision		Revision as of 23:02, 11 October 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic (NSAID) ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic (NSAID) ]]
	'''Meloxicam''' is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, meloxicam is an analgesic, anti-inflammatory and antipyretic. It is a selective inhibitor of cyclo-oxygenase-2 (COX-2). It is used to treat pain and inflammation in rheumatic arthritis, osteoarthritis and ankylosing spondylitis.		'''Meloxicam''' (:中文 [[美洛昔康 ]])is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, meloxicam is an analgesic, anti-inflammatory and antipyretic. It is a selective inhibitor of cyclo-oxygenase-2 (COX-2). It is used to treat pain and inflammation in rheumatic arthritis, osteoarthritis and ankylosing spondylitis.

			==Drug name==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名
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	\|}		\|}
	==Mechanism of Action==		==Mechanism of Action==
	Non-opioid Analgesic (NSAID) Anti-inflammatory agent, COX-2 inhibitor		Non-opioid Analgesic (NSAID)
			Anti-inflammatory agent
			COX-2 inhibitor

	==Dosage==		==Dosage==

Ctol2 at 09:13, 30 September 2020

2020-09-30T09:13:28Z

← Older revision		Revision as of 05:13, 30 September 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic (NSAID) ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic (NSAID) ]]
	'''Meloxicam''' is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, meloxicam is an analgesic, anti-inflammatory and antipyretic. It is a selective inhibitor of cyclo-oxygenase-2 (COX-2). It is used to treat pain and inflammation in rheumatic arthritis, osteoarthritis and ankylosing spondylitis.		'''Meloxicam''' is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, meloxicam is an analgesic, anti-inflammatory and antipyretic. It is a selective inhibitor of cyclo-oxygenase-2 (COX-2). It is used to treat pain and inflammation in rheumatic arthritis, osteoarthritis and ankylosing spondylitis.

	~~==Mechanism of Action==~~
	~~Non-opioid Analgesic (NSAID) Anti-inflammatory agent, COX-2 inhibitor~~


	{\| class="wikitable"		{\| class="wikitable"
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	\|P1S1S3		\|P1S1S3
	\|}		\|}
			==Mechanism of Action==
			Non-opioid Analgesic (NSAID) Anti-inflammatory agent, COX-2 inhibitor

	==Dosage==		==Dosage==

Ctol2: /* Precautions */

2020-09-30T09:12:54Z

Precautions

← Older revision		Revision as of 05:12, 30 September 2020
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	Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.		Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.

	~~'''~~Note:		===Note===
	It is recommended to withhold meloxicam for at least four to six half-lives prior to surgical or dental procedures due to increased risk for taste perversion, ulcerative stomatitis and dry mouth.		It is recommended to withhold meloxicam for at least four to six half-lives prior to surgical or dental procedures due to increased risk for taste perversion, ulcerative stomatitis and dry mouth.


	== FAQ ==		== FAQ ==

Ctol2: /* In the treatment of acute exacerbations of osteoarthritis */

2020-09-30T09:12:28Z

In the treatment of acute exacerbations of osteoarthritis

← Older revision		Revision as of 05:12, 30 September 2020
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	===In the treatment of acute exacerbations of osteoarthritis===		===In the treatment of acute exacerbations of osteoarthritis===
	Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.		Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.


	===Administration in children===		===Administration in children===

Ctol2 at 09:12, 30 September 2020

2020-09-30T09:12:17Z

← Older revision		Revision as of 05:12, 30 September 2020
Line 1:		Line 1:
	[[Category: Drugs]] [[Category:Non-opioid Analgesic (NSAID) ]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic (NSAID) ]]
			'''Meloxicam''' is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, meloxicam is an analgesic, anti-inflammatory and antipyretic. It is a selective inhibitor of cyclo-oxygenase-2 (COX-2). It is used to treat pain and inflammation in rheumatic arthritis, osteoarthritis and ankylosing spondylitis.
	~~==Introduction==~~
	Meloxicam, is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, meloxicam is an analgesic, anti-inflammatory and antipyretic. It is a selective inhibitor of cyclo-oxygenase-2 (COX-2). It is used to treat pain and inflammation in rheumatic arthritis, osteoarthritis and ankylosing spondylitis.

	==Mechanism of Action==		==Mechanism of Action==
	Non-opioid Analgesic (NSAID)		Non-opioid Analgesic (NSAID) Anti-inflammatory agent, COX-2 inhibitor
	Anti-inflammatory agent, COX-2 inhibitor


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	It is used by mouth or by injection into a vein. It is recommended that it be used for as short a period as possible and at a low dose.		It is used by mouth or by injection into a vein. It is recommended that it be used for as short a period as possible and at a low dose.

	~~'''~~In the treatment of rheumatoid arthritis and ankylosing spondylitis:		===In the treatment of rheumatoid arthritis and ankylosing spondylitis===
	Oral: 15 mg daily as a single dose.		Oral: 15 mg daily as a single dose.
	hose with an increased risk of adverse reactions should be started on 7.5 mg daily. A dose of 7.5 mg daily is recommended for long-term treatment in the elderly.		hose with an increased risk of adverse reactions should be started on 7.5 mg daily. A dose of 7.5 mg daily is recommended for long-term treatment in the elderly.

	~~'''~~In the treatment of acute exacerbations of osteoarthritis:		===In the treatment of acute exacerbations of osteoarthritis===
	Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.		Oral: 7.5 mg daily. Increased if necessary, to a maximum of 15 mg daily as a single dose.


	~~'''~~Administration in children		===Administration in children===

	BNFC has suggested the following oral doses, according to body-weight, for the relief of pain and inflammation in juvenile idiopathic arthritis and other musculoskeletal disorders in children aged 12 to 17 years who are intolerant of other NSAIDs:		BNFC has suggested the following oral doses, according to body-weight, for the relief of pain and inflammation in juvenile idiopathic arthritis and other musculoskeletal disorders in children aged 12 to 17 years who are intolerant of other NSAIDs:
	*Less than 50 kg: 7.5 mg once daily		*Less than 50 kg: 7.5 mg once daily
	*50 kg and over: 15 mg once daily		*50 kg and over: 15 mg once daily

	~~'''~~Administration in renal impairment		===Administration in renal impairment===
	Meloxicam is contra-indicated in patients with severe renal impairment.		Meloxicam is contra-indicated in patients with severe renal impairment.
	However, in dialyzed patients, meloxicam may be given in a dose of 7.5 mg daily orally or rectally as suppositories. No dose reduction is required in those with mild to moderate renal impairment (creatinine clearance of greater than 25 mL/min).		However, in dialyzed patients, meloxicam may be given in a dose of 7.5 mg daily orally or rectally as suppositories. No dose reduction is required in those with mild to moderate renal impairment (creatinine clearance of greater than 25 mL/min).
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	==Side Effects==		==Side Effects==

	~~As for~~ NSAIDs in general		===NSAIDs in general===

	Meloxicam can result in gastrointestinal toxicity and bleeding, headaches, rash and very dark or black stool (a sign of intestinal bleeding). Like other NSAIDs, its use is associated with an increased risk of cardiovascular events such as heart attack and stroke.		Meloxicam can result in gastrointestinal toxicity and bleeding, headaches, rash and very dark or black stool (a sign of intestinal bleeding). Like other NSAIDs, its use is associated with an increased risk of cardiovascular events such as heart attack and stroke.
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	NSAID can also worsen asthma.		NSAID can also worsen asthma.

	~~'''~~Cardiovascular risk		===Cardiovascular risk===
	Chronic use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.		Chronic use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

	~~'''~~Skin		===Skin===
	NSAIDs has been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis which can be fatal.		NSAIDs has been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis which can be fatal.

	~~'''~~Geriatrics		===Geriatrics===
	Use of meloxicam is not recommended in people with peptic ulcer disease or increased gastrointestinal bleed risk, including those over 75 years of age, or those taking medications associated with bleeding risk. Adverse events have been found to be dose-dependent and associated with length of treatment.		Use of meloxicam is not recommended in people with peptic ulcer disease or increased gastrointestinal bleed risk, including those over 75 years of age, or those taking medications associated with bleeding risk. Adverse events have been found to be dose-dependent and associated with length of treatment.

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	==Drug Management==		==Drug Management==
	~~'''~~Monitoring:		===Monitoring===
	*Regular physical examination to detect edema and signs of central nervous side effects.		*Regular physical examination to detect edema and signs of central nervous side effects.
	*Blood pressure checks will reveal development of hypertension		*Blood pressure checks will reveal development of hypertension
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	This is particularly important if Indomethacin is given together with an ACE inhibitor or with potassium-sparing diuretic (e.g. spironolactone), because these combinations can lead to hyperkalemia and/or serious kidney failure.		This is particularly important if Indomethacin is given together with an ACE inhibitor or with potassium-sparing diuretic (e.g. spironolactone), because these combinations can lead to hyperkalemia and/or serious kidney failure.

	~~'''~~Drug Interaction:		===Drug Interaction===
	*Increases the blood thinning effects of warfarin because it displaces them from their plasma protein binding and increases their free concentrations in the bloodstream.		*Increases the blood thinning effects of warfarin because it displaces them from their plasma protein binding and increases their free concentrations in the bloodstream.
	*Increase the risk of adverse effects of lithium, methotrexate and cardiac glycosides by lowering their excretion via the kidneys.		*Increase the risk of adverse effects of lithium, methotrexate and cardiac glycosides by lowering their excretion via the kidneys.
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	*Hypertension		*Hypertension

	~~'''~~Contraindication:		===Contraindication===
	*Allergy to indomethacin, aspirin or other NSAIDs		*Allergy to indomethacin, aspirin or other NSAIDs
	*History of allergic reactions (bronchospasm, rhinitis, urticaria) following the use of other NSAIDs such as aspirin		*History of allergic reactions (bronchospasm, rhinitis, urticaria) following the use of other NSAIDs such as aspirin
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	*Can lead to onset of new hypertension or worsening of pre-existing hypertension		*Can lead to onset of new hypertension or worsening of pre-existing hypertension

	~~'''~~Precautions		===Precautions===
	Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.		Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.

Helen: /* What happen if I miss a dose? */

2020-09-29T07:09:53Z

What happen if I miss a dose?

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	If emergency situation, call 999		If emergency situation, call 999

	=== What happen if I miss a dose? ===		==== What happen if I miss a dose? ====
	Take it as soon as you		Take it as soon as you
	remember. If it is near the time		remember. If it is near the time