Naproxen - Revision history

Helen at 01:39, 14 October 2020

2020-10-14T01:39:07Z

← Older revision		Revision as of 21:39, 13 October 2020
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	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.




	.

	==Pharmacokinetics==		==Pharmacokinetics==

	Naproxen and naproxen sodium are readily absorbed from the gastrointestinal tract. Peak plasma concentrations occur about 1 to 2 hours after ingestion of naproxen sodium and about 2 to 4 hours after ingestion of naproxen.		Naproxen and naproxen sodium are readily absorbed from the gastrointestinal tract. Peak plasma concentrations occur about 1 to 2 hours after ingestion of naproxen sodium and about 2 to 4 hours after ingestion of naproxen.

Helen: /* Side Effects */

2020-10-14T01:37:42Z

Side Effects

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	{\| class="wikitable"		{\| class="wikitable"
	!~~blood~~		!Blood
	\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported		\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported
	\|-		\|-
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	\|Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk		\|Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk
	\|}		\|}


	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

Helen at 01:34, 14 October 2020

2020-10-14T01:34:00Z

← Older revision		Revision as of 21:34, 13 October 2020
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	==Side Effects==		==Side Effects==
			NSAIDs in genera
			{\| class = "wikitable"
			!style="text-align: left"\| Common side effects
			\|heartburn, nausea, dyspepsia, diarrhea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.
			\|}

	~~===NSAIDs in general===~~
	Naproxen suppositories can cause rectal irritation and occasional bleeding.		Naproxen suppositories can cause rectal irritation and occasional bleeding.

	Naproxen should be used with caution in renal impairment, and use is not recommended in patients whose creatinine clearance is less than 20 mL/min.		Naproxen should be used with caution in renal impairment, and use is not recommended in patients whose creatinine clearance is less than 20 mL/min.

	~~Common side effects include heartburn~~, ~~nausea, dyspepsia, diarrhea, constipation, gastrointestinal ulceration/~~bleeding, ~~headache~~, ~~dizziness~~, ~~rash~~, ~~salt and fluid retention~~, and high ~~blood pressure.~~		{\| class="wikitable"
			!blood
			\|localized spontaneous bleeding, bruising and prolonged bleeding time have been reported
			\|-
			!Asthma
			\|Can be worsen
			\|-
			!Cardiovascular risk
			\|Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.
			\|-
			!Skin
			\|NSAIDs have been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, which can be fatal.
			\|-
			!Muscle cramps
			\|Naproxen may cause muscle cramps in the legs in 3% of people
			\|-
			!Stomach ulcers
			\|Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk
			\|}

	~~Note: Naproxen poses an intermediate risk of stomach ulcers compared with ibuprofen, which is low-risk, and indomethacin which is high-risk.~~

	~~Effects on the blood: localized spontaneous bleeding, bruising and prolonged bleeding time have been reported.~~

	It also increases the risk of heart attack, stroke, kidney failure and liver failure.		It also increases the risk of heart attack, stroke, kidney failure and liver failure.

	~~NSAID can also worsen asthma.~~

	~~Naproxen may cause muscle cramps in the legs in 3% of people.~~

	~~===Cardiovascular risk===~~
	Chronic ibuprofen use has been found correlated with risk of progression to hypertension and myocardial infarction (heart attack). Both the U.S. Food and Drug Administration (FDA) and The European Medicines Agency (EMA) issues warnings of increased heart attack and stroke risk.

	~~===Skin===~~		.
	NSAIDs has been associated with the onset of bullous pemphigoid. It can also cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis which can be fatal.

	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* Drug name */

2020-10-14T01:24:43Z

Drug name

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	\|-		\|-
	\|Naproxen Sodium Tablet 275mg		\|Naproxen Sodium Tablet 275mg
	\|		\|NAPR01
	\|P1S1S3		\|P1S1S3
	\|}		\|}

Helen at 03:53, 12 October 2020

2020-10-12T03:53:00Z

← Older revision		Revision as of 23:53, 11 October 2020
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	[[Category: Drugs]][[Category: Non-opioid Analgesic (NSAID)]]		[[Category: Drugs]][[Category: Non-opioid Analgesic (NSAID)]]
	'''Naproxen'''(:中文 [[~~吲哚美辛~~ ]])is an anti-steroidal anti inflammatory drug, an NSAID. As an NSAID, indomethacin is an analgesic, anti-inflammatory and antipyretic.		'''Naproxen'''(:中文 [[ 萘普生]])is an anti-steroidal anti inflammatory drug, an NSAID. As an NSAID, indomethacin is an analgesic, anti-inflammatory and antipyretic.
	Clinical indications for naproxen include:		Clinical indications for naproxen include:
	Musculoskeletal and joint disorders		Musculoskeletal and joint disorders

Helen: /* Administration in children */

2020-10-12T03:50:12Z

Administration in children

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	===Administration in children===		===Administration in children===
	{\| class="wikitable"		{\| class="wikitable"
	! ~~juvenile~~ idiopathic arthritis		!Juvenile idiopathic arthritis
	(2 years and over)		(2 years and over)
			\|Oral: 10 mg/kg daily in 2 divided doses.
	\|-		\|-
	~~\|Oral: 10 mg/kg daily in 2 divided doses.~~		!Musculoskeletal disorders
	\|~~Aged 1 month to 17 years;~~ Oral: 0.5 ~~to 1~~ mg/kg twice daily.		\|Oral: 5 mg/kg twice daily (maximum of 1 g daily).
	\|}		\|}

Helen: /* Administration in children */

2020-10-12T03:48:50Z

Administration in children

← Older revision		Revision as of 23:48, 11 October 2020
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	===Administration in children===		===Administration in children===
	{\| class="wikitable"		{\| class="wikitable"
	!		! juvenile idiopathic arthritis
			(2 years and over)
			\|-
			\|Oral: 10 mg/kg daily in 2 divided doses.
	\|Aged 1 month to 17 years; Oral: 0.5 to 1 mg/kg twice daily.		\|Aged 1 month to 17 years; Oral: 0.5 to 1 mg/kg twice daily.
	\|}		\|}

Helen: /* Dosage */

2020-10-12T03:47:41Z

Dosage

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	==Dosage==		==Dosage==
	{\| class="wikitable"		{\| class="wikitable"
	! ~~rheumatic~~ disorders		!Rheumatic disorders
	\|''Oral'' : 500 mg to 1 g daily either as a single dose or in 2 divided doses.		\|''Oral'' : 500 mg to 1 g daily either as a single dose or in 2 divided doses.
	\|-		\|-
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	\|''Oral'' : initially 500 mg, followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and 1 g thereafter.		\|''Oral'' : initially 500 mg, followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and 1 g thereafter.
	\|-		\|-
	!~~acute~~ musculoskeletal disorders		!Acute musculoskeletal disorders
	\|''Oral'' : initially 500 mg, followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and 1 g thereafter.		\|''Oral'' : initially 500 mg, followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and 1 g thereafter.
	\|}		\|}

	Naproxen has been given rectally in similar doses to those used orally.		Naproxen has been given rectally in similar doses to those used orally.
			===Administration in children===
			{\| class="wikitable"
	~~Oral: 500 mg to 1 g daily either as a single dose or~~ in ~~2 divided doses.~~		!
			\|Aged 1 month to 17 years; Oral: 0.5 to 1 mg/kg twice daily.
	~~In other painful conditions such as dysmenorrhea and acute musculoskeletal disorders:~~		\|}

	~~Oral: initially 500 mg, followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and~~ 1 ~~g thereafter.~~


	~~In acute gout:~~
	~~Oral: initial dose 750 mg followed by 250 mg every 8 hours~~

	~~Naproxen has been given rectally in similar doses~~ to ~~those used orally.~~

	~~'''Administration in children~~

	~~In the treatment of juvenile idiopathic arthritis for children aged 2~~ years ~~and over:~~

	Oral: ~~10 mg/kg daily in 2 divided doses~~.

	~~For musculoskeletal disorders,~~

	~~oral:~~ 5 mg/kg twice daily ~~(maximum of 1 g daily)~~.

	==Side Effects==		==Side Effects==

Helen: /* Mechanism of Action */

2020-10-12T03:43:41Z

Mechanism of Action

← Older revision		Revision as of 23:43, 11 October 2020
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	===Naproxen 250mg===		===Naproxen 250mg===
	[[File:Naproxen 250mg.mp3]]		[[File:Naproxen 250mg.mp3]]
	~~==Mechanism of Action==~~
	~~Non-opioid Analgesic (NSAID)~~
	~~Anti-inflammatory agent,~~
	~~Nonselective COX inhibitor, inhibits COX-1 and COX-2~~


	==Drug name==		==Drug name==
	{\| class="wikitable"		{\| class="wikitable"

Helen at 03:43, 12 October 2020

2020-10-12T03:43:25Z

@@ Line 1: / Line 1: @@
 [[Category: Drugs]][[Category: Non-opioid Analgesic (NSAID)]]
-'''Naproxen'''
+'''Naproxen'''(:中文 [[吲哚美辛 ]])is an anti-steroidal anti inflammatory drug, an NSAID. As an NSAID, indomethacin is an analgesic, anti-inflammatory and antipyretic.
 {| class="wikitable"
 !Generic Name 藥名
@@ Line 10: / Line 29: @@
 |P1S1S3
 |}
-==Pronunciation==
 ==Mechanism of Action==
 Non-opioid Analgesic (NSAID)
 Anti-inflammatory agent,
-Nonselective COX inhibitor, inhibits COX-1 and COX-2
+Nonselective COX inhibitor, inhibits COX-1 and COX-2 with relative equipotency
 ==Dosage==
 Oral:  500 mg to 1 g daily either as a single dose or in 2 divided doses.