Zeki at 07:16, 22 August 2024

2024-08-22T07:16:40Z

← Older revision		Revision as of 03:16, 22 August 2024
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			==Pharmacokinetics==
			*Absorption: It is well absorbed orally. Peak plasma concentrations occur approximately 7 to 8.5 hours after oral administration.
			*Metabolism: Nortriptyline is extensively metabolized in the live, primarily by the cytochrome P450 enzyme CYP2D6. It undergoes first-pass metabolism, which affects its bioavailability.
			*Elimination: Excreted in urine and fecal
			*Drug Onset: It may take 1 to 4 weeks for the full antidepressant effect

			==Drug Precautions==
			'''Pregnancy

			Use only if the potential benefit outweighs risk.

			'''Breastfeeding

			Present in breast milk, use caution.

			'''Children and Elderly
			*Not recommended for children
			*Lower doses are recommended for the elderly

			'''Monitoring items
			*Regular monitoring for signs for serotonin syndrome, especially when starting or adjuting doses.
			*Monitor blood counts due to the risk of agranulocytosis.
			*Assess liver function periodically
			*Suicidal thoughts, especially in young adults

			'''Drug Interactions
			*Nortriptyline is primarily metabolized by CYP2D6 and CYP3A4. Drugs that inhibit these enzymes can increase nortriptyline levels, leading to increased side effects.
			**Examples of inhibitors include: Cimetidine and Quinidine
			*Concomitant use with other serotonergic drugs (e.g. SSRIs, SNRIs) can increase the risk of serotonin syndrome.

			==FAQ==
			'''How Should I Take the Tablet?

			Take orally with or without food, usually 1-4 times daily as directed by your doctor

			'''What should I avoid while taking?

			Avoid alcohol, which may increase side effects. Use caution when driving or operating machinery due to potential drowsiness.

			'''What Happens if I Miss a Dose?

			Take it as soon as you remember. If it is close to your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.

Zeki: Created page with "Category: DrugsCategory: Tricyclic antiperessant drug '''Antidepressant Drug''' '''Drug class: :Category: Tricyclic antiperess..."

2024-08-22T06:54:17Z

Created page with "Category: Drugs Category: Tricyclic antiperessant drug '''Antidepressant Drug''' '''Drug class: :Category: Tricyclic antiperess..."

New page

[[Category: Drugs]][[Category: Tricyclic antiperessant drug]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Tricyclic antiperessant drug |Tricyclic Antiperessant Drug]]

'''Nortriptyline'''（中文：[[去甲替林]]）
==Common Strengths of Nortriptyline==
Nortriptyline are available in the following strengths:
*10 mg, 25 mg, 50 mg, 75 mg capsules

==Drug Trade Names of Nortriptyline==
*Pamelor
*Aventyl

==Drug Usage==
*Treatment of depression
*Off-Label Uses: Neuropathic pain, irritable bowel syndrome (IBS), migraine prevention, and panic disorder

==Mechanism of Action==
*Inhibits reuptake of serotonin and norepinephrine at neuronal cell membranes
*More selective reuptake inhibition for norepinephrine

==Route of Administration==
Oral

==Dosages==
*Adults: 25 mg orally, taken 3 to 4 times per day. Maximum dose up to 150 mg/day.
*Elderly: 30 to 50 mg/day in divided doses or as a single daily dose.

==Side Effects==
{| class="wikitable"
!style="text-align: left"| Frequency
!Adverse reactions
|-
| rowspan="10" | '''Common
| Drowsiness/sedation
|-
| Dizziness
|-
| Dry mouth
|-
| Blurred vision
|-
| Constipation
|-
| Increased blood pressure
|-
| Numbness or tingling in hands/feet
|-
| Nausea, vomiting, loss of appetite
|-
| Rash, itching
|-
| Breast swelling (in men or women)
|-
| rowspan="10" | '''Serious
| Suicidal thoughts and behaviors (especially in young adults)
|-
| Serotonin syndrome (confusion, fast heart rate, agitation)
|-
| Agranulocytosis (severe reduction in white blood cells)
|-
| Seizures
|-
| Angle-closure glaucoma (eye pain, blurred vision)
|-
| Severe allergic reactions (rash, hives, swelling, trouble breathing)
|-
| Severe skin reactions (blistering, peeling skin)
|-
| Fast, irregular heartbeat
|-
| Painful or difficult urination
|-
| Jaundice (yellowing of skin or eyes)
|}

Nortriptyline - Revision history

Zeki at 07:16, 22 August 2024

Zeki: Created page with "Category: DrugsCategory: Tricyclic antiperessant drug '''Antidepressant Drug''' '''Drug class: :Category: Tricyclic antiperess..."