Oxcarbazepine - Revision history

Helen at 02:45, 9 October 2020

2020-10-09T02:45:03Z

← Older revision		Revision as of 22:45, 8 October 2020
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	[[Category: Drugs]] [[Category: ~~Anticonvulsant medication~~]]		[[Category: Drugs]] [[Category: Seizures]]
	'''Oxcarbazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.		'''Oxcarbazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.

Helen at 01:07, 8 October 2020

2020-10-08T01:07:18Z

← Older revision		Revision as of 21:07, 7 October 2020
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	[[Category: Drugs]] [[Category: Anticonvulsant medication]]		[[Category: Drugs]] [[Category: Anticonvulsant medication]]
	'''~~Carbamazepine~~'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.		'''Oxcarbazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.

	==藥名==		==藥名==

Ctol2 at 07:26, 7 October 2020

2020-10-07T07:26:53Z

← Older revision		Revision as of 03:26, 7 October 2020
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	'''Carbamazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.		'''Carbamazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.

			==藥名==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名

Ctol2 at 07:26, 7 October 2020

2020-10-07T07:26:28Z

← Older revision		Revision as of 03:26, 7 October 2020
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	[[Category: Drugs]] [[Category: Anticonvulsant medication]]		[[Category: Drugs]] [[Category: Anticonvulsant medication]]

	~~==Introduction==~~
	'''Carbamazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.		'''Carbamazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.

Helen at 06:53, 7 October 2020

2020-10-07T06:53:57Z

← Older revision		Revision as of 02:53, 7 October 2020
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	==Introduction==		==Introduction==
	'''Carbamazepine''' is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.		'''Carbamazepine'''(中文:[[ 奧卡西平]])is an anticonvulsant medication used primarily in the treatment of epilepsy. It has been used both alone and as add-on therapy for partial seizures with or without secondary generalization.

	{\| class="wikitable"		{\| class="wikitable"

Helen at 01:55, 6 October 2020

2020-10-06T01:55:50Z

← Older revision		Revision as of 21:55, 5 October 2020
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	#This medicine may make you sleepy. If this happens, do not drive or use tools or machines		#This medicine may make you sleepy. If this happens, do not drive or use tools or machines
	#Do not stop taking this medicine unless your doctor tells you to stop		#Do not stop taking this medicine unless your doctor tells you to stop

			== FAQ ==
			==== How should I take the tablet? ====
			Donepezil tablet and orodispersible tablet should be taken orally at bedtime, or as directed by the doctor. The orodispersible tablet should be placed on the tongue and allowed to disperse before swallowing with or without water. Both formulations can be taken with or without food.
			==== What should I avoid while taking? ====
			Avoid abruptly discontinue the medication.
			==== What happen if I overdose? ====
			Contact your primary care doctor.
			If emergency situation, call 999
			==== What happen if I miss a dose? ====
			Take it as soon as you
			remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Helen at 01:51, 6 October 2020

2020-10-06T01:51:18Z

@@ Line 72: / Line 72: @@
 |}
-===Drug interaction===
+==Drug Management==
-'''Monitoring '''
+===Monitoring===
 *signs of blood, liver, or skin disorders. Seek immediate medical attention if symptoms such as fever, rash, blistering, mouth ulcers, bruising or bleeding develop.
 *Patients with heart failure should be weighed regularly to detect fluid retention.
@@ Line 79: / Line 79: @@
 *Hyponatremia (monitor plasma-sodium concentration in patients at risk).
-'''Drug interaction'''
+===Drug interaction===
 Plasma concentrations of the active metabolite of oxcarbazepine may be reduced by strong inducers of cytochrome P450 isoenzymes, such as phenytoin, or phenobarbital. Oxcarbazepine and its metabolite also have the capacity to induce CYP3A4 and CYP3A5 with the possibility of reducing plasma concentrations of drugs such as dihydropyridine calcium-channel blockers, and oral contraceptives.

Helen at 01:43, 6 October 2020

2020-10-06T01:43:41Z

← Older revision		Revision as of 21:43, 5 October 2020
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	\|Excreted in the urine, with faeces accounting to less than 4%.		\|Excreted in the urine, with faeces accounting to less than 4%.
	\|}		\|}

			===Drug interaction===
			'''Monitoring '''
			*signs of blood, liver, or skin disorders. Seek immediate medical attention if symptoms such as fever, rash, blistering, mouth ulcers, bruising or bleeding develop.
			*Patients with heart failure should be weighed regularly to detect fluid retention.
			*Patients with pre-existing cardiac conduction disorders should be carefully monitored.
			*Hyponatremia (monitor plasma-sodium concentration in patients at risk).

			'''Drug interaction'''
			Plasma concentrations of the active metabolite of oxcarbazepine may be reduced by strong inducers of cytochrome P450 isoenzymes, such as phenytoin, or phenobarbital. Oxcarbazepine and its metabolite also have the capacity to induce CYP3A4 and CYP3A5 with the possibility of reducing plasma concentrations of drugs such as dihydropyridine calcium-channel blockers, and oral contraceptives.

Helen at 01:38, 6 October 2020

2020-10-06T01:38:55Z

← Older revision		Revision as of 21:38, 5 October 2020
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	*Galactorrhea		*Galactorrhea
	*Photosensitivity leading to severe sunburns as a result of sun exposure		*Photosensitivity leading to severe sunburns as a result of sun exposure

			==Pharmacokinetics==
			{\|class="wikitable"
			!style="text-align: left"\| Oral bioavailability
			\|Oxcarbazepine is a prodrug which is metabolized to its pharmacologically active metabolite licarbazepine. It has high bioavailability upon oral administration.
			\|-
			!style="text-align: left"\| Onset of action
			\|The half-life of oxcarbazepine is about 2 hours, whereas licarbazepine has a half-life of 9 hours. The latter provides most of the antiepileptic activity
			\|-
			!style="text-align: left"\| Metabolism
			\|Licarbazepine is metabolized in the liver
			\|-
			!style="text-align: left"\| Elimination half-life
			\|Excreted in the urine, with faeces accounting to less than 4%.
			\|}

Helen at 01:37, 6 October 2020

2020-10-06T01:37:39Z

← Older revision		Revision as of 21:37, 5 October 2020
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	Usual maintenance doses in adjunctive therapy around 30mg/kg daily.		Usual maintenance doses in adjunctive therapy around 30mg/kg daily.
	\|}		\|}

			==Side Effects==

			Common side effects include:
			*Drowsiness, dizziness and headaches
			*Gastrointestinal disturbances, such as nausea and vomiting
			*The loss of full control of bodily movements (motor coordination impairment)
			*Increased risks of hyponatremia and SIADH
			*Blood disorders (such as decreased white blood cell or platelet counts)

			Serious side effects may include:
			*Skin rashes, exfoliative dermatitis, epidermal necrolysis, Stevens-Johnson syndrome, and SLE
			*Decreased bone marrow function
			*Suicidal thoughts
			*Abnormal heart rhythms
			*Blurry or double vision, nystagmus
			*Male infertility
			*Osteoporosis
			*Gynecomastia
			*Galactorrhea
			*Photosensitivity leading to severe sunburns as a result of sun exposure