Oxycodone - Revision history

Ctol2: /* Side Effects */

2020-09-30T10:04:49Z

Side Effects

← Older revision		Revision as of 06:04, 30 September 2020
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	==Side Effects==		==Side Effects==
			Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression.
	===Opioid Analgesic in general===		===Opioid Analgesic in general===
	The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.		The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.
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	#Constipation can be treated with laxatives such as senna tables and lactulose.		#Constipation can be treated with laxatives such as senna tables and lactulose.
	#Nausea and vomiting can be alleviated by metoclopramide.		#Nausea and vomiting can be alleviated by metoclopramide.
	#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe respiratory depression and coma.		#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe respiratory depression and coma.

	~~Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression~~.

	==Pharmacokinetics==		==Pharmacokinetics==

2020-09-30T10:04:16Z

Drug Management

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	!Caution		!Caution
	\|Pancreatitis, toxic psychosis		\|Pancreatitis, toxic psychosis
	\|-		Tolerance and dependence
	\|
	\|Tolerance and dependence
	\|-		\|-
	!Contraindication		!Contraindication

2020-09-30T10:04:01Z

Pharmacokinetics

← Older revision		Revision as of 06:04, 30 September 2020
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	==Pharmacokinetics==		==Pharmacokinetics==

	{\|class="wikitable"		{\|class="wikitable"
	!Oral bioavailability		!Oral bioavailability
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	\|The oxycodone and metabolites are excreted primarily via the kidneys		\|The oxycodone and metabolites are excreted primarily via the kidneys
	\|}		\|}


	==Drug Management==		==Drug Management==

2020-09-30T10:03:36Z

Treatment of Adverse Effects

← Older revision		Revision as of 06:03, 30 September 2020
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	#Constipation can be treated with laxatives such as senna tables and lactulose.		#Constipation can be treated with laxatives such as senna tables and lactulose.
	#Nausea and vomiting can be alleviated by metoclopramide.		#Nausea and vomiting can be alleviated by metoclopramide.
	#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for		#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for rapid reversal of the severe respiratory depression and coma.
	rapid reversal of the severe respiratory depression and coma.

	Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression.		Euphoria, nausea and vomiting, respiratory depression, constipation and cough suppression.

2020-09-30T10:03:19Z

Side Effects

← Older revision		Revision as of 06:03, 30 September 2020
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	==Side Effects==		==Side Effects==
			===Opioid Analgesic in general===
	~~As for '''~~Opioid Analgesic
	in general

	The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.		The commonest adverse effects are nausea, vomiting, constipation, drowsiness and confusion.

	Large doses of opioids produce respiratory depression and hypotension, with circulatory failure and deepening coma. Death may occur from respiratory failure.		Large doses of opioids produce respiratory depression and hypotension, with circulatory failure and deepening coma. Death may occur from respiratory failure.

	~~'''~~Treatment of Adverse Effects		===Treatment of Adverse Effects===
			#Constipation can be treated with laxatives such as senna tables and lactulose.
	1. Constipation can be treated with laxatives such as senna tables and lactulose.		#Nausea and vomiting can be alleviated by metoclopramide.
			#Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for
	2. Nausea and vomiting can be alleviated by metoclopramide.

	3. Intensive supportive therapy may be required to correct respiratory failure and shock. Naloxone is used for
	rapid reversal of the severe respiratory depression and coma.		rapid reversal of the severe respiratory depression and coma.

2020-09-30T10:02:24Z

Dosage

← Older revision		Revision as of 06:02, 30 September 2020
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	==Dosage==		==Dosage==

	Moderate to severe pain:		===Moderate to severe pain===

	A usual oral starting dose for opioid-naïve patients in severe pain is 5 mg every 4 to 6 hours increased thereafter as necessary according to response.		A usual oral starting dose for opioid-naïve patients in severe pain is 5 mg every 4 to 6 hours increased thereafter as necessary according to response.

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	{\| class="wikitable"		{\| class="wikitable"
	!Oral		!Oral
	\|~~immediate~~ release formulations : 5mg q4-6h, max 400 mg PRN		\|Immediate release formulations : 5mg q4-6h, max 400 mg PRN
			Modified release formulation: 10mg q12h, max 200 mg q12h PRN
	\|-		\|-
	\|		!Intravenous
	~~\|modified release formulation: 10mg q12h, max 200 mg q12h PRN~~
	\|-
	!~~intravenous~~
	\|1 to 10 mg initially, given over 1 to 2 minutes, and repeated every 4 hours.		\|1 to 10 mg initially, given over 1 to 2 minutes, and repeated every 4 hours.
	\|}		\|}
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	\|}		\|}

	~~'''~~Administration in children		===Administration in children===

	Although oxycodone hydrochloride is not licensed for use in children under 18 years old, the BMCF suggests that it may be given for the treatment of moderate to severe pain in palliative care.		Although oxycodone hydrochloride is not licensed for use in children under 18 years old, the BMCF suggests that it may be given for the treatment of moderate to severe pain in palliative care.

2020-09-30T10:00:45Z

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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: Pain relief]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: Pain relief]]

	'''Oxycodone'''		'''Oxycodone'''

2020-09-30T10:00:31Z

← Older revision		Revision as of 06:00, 30 September 2020
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	[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: Pain relief]]		[[Category: Drugs]] [[Category: Non-opioid Analgesic]] [[Category: Pain relief]]

	~~== Pronunciation ==~~		'''Oxycodone'''

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

			==Mechanism of Action==
	Equivalent doses of opioid analgesics		Equivalent doses of opioid analgesics

2020-09-30T06:57:52Z

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	\|Avoid in moderate to severe hepatic impairment		\|Avoid in moderate to severe hepatic impairment
	\|}		\|}

			== FAQ ==
			=== How should I take the tablet? ===
			Follow the doctor's prescription,
			Take with or without food
			Take the medication with plenty of water
			Can be crushed
			=== What should I avoid while taking? ===
			Avoid abrupt withdrawal
			=== What happen if I overdose? ===
			Emergency situation, called 999 immediately
			Antidote: Naloxone
			=== What happen if I miss a dose? ===
			PO: Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose.
			Take your next dose at the regular time. Do not double the dose to catch up.
			IV infusion and SC : adminstered by professionals

2020-09-30T06:56:40Z

Drug Management

← Older revision		Revision as of 02:56, 30 September 2020
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	\|Pancreatitis, toxic psychosis		\|Pancreatitis, toxic psychosis
	\|-		\|-
	\|
	\|		\|
	\|Tolerance and dependence		\|Tolerance and dependence