Pantoprazole (PANTOLOC) - Revision history

Annayung at 04:47, 12 January 2025

2025-01-12T04:47:20Z

← Older revision		Revision as of 00:47, 12 January 2025
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	==Common Strengths of Pantoprazole tablet==		==Common Strengths of Pantoprazole tablet==

	Pantoprazole ~~tablet~~ are available in the following strengths:		Pantoprazole tablets are available in the following strengths:

	*20 mg delayed-release oral tablets		*20 mg delayed-release oral tablets
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	Pantoprazole is used for:		Pantoprazole is used for:

	~~Healing of erosive esophagitis (EE)~~		Gastric ulcer, duodenal ulcer

	~~Management~~ of ~~erosive esophagitis due to~~ GERD		Treatment of gastroesophageal reflux disease (GERD)

			Prevention of gastric damage in patients taking NSAIDs

	~~Treatment of gastroesophageal reflux disease~~ (~~GERD~~)		Zollinger-Ellison syndrome (and other hypersecretory conditions)

	~~Prevention~~ of ~~gastric damage in patients taking NSAIDs~~		Eradication of Helicobacter pylori

	==Mechanism of Action==		==Mechanism of Action==

	Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach		Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking the final step of gastric acid production in the stomach, significantly reducing gastric acidity for up to 24 hours or more.

	==Route of Administration==		==Route of Administration==
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	==Dosages ==		==Dosages ==

	~~For adults~~ and ~~children aged 12 years~~ and ~~older~~, ~~the typical dosage is:~~		Gastric ulcer, duodenal ulcer: By intravenous injection, or by intravenous infusion 40mg daily until oral administration can be resumed

			Gastric ulcer, duodenal ulcer: By mouth, 40 mg daily; increased if necessary up to 80mg daily

			GERD: 20-80 mg daily for 4 weeks, continue for further 4 weeks if not fully healed, dose to be taken in the morning; maintenance 20 mg daily and increased to 40 mg daily, increased only if symptoms return

			Propylaxis of NSAID-associated ulcer: 20 mg daily

			Zollinger-Ellison syndrome (and other hypersecretory conditions): intially 80 mg daily, adjusted according to response

	~~GERD~~: 40 mg ~~once~~ daily ~~for up to 8 weeks~~		Helicobacter pylori eradication: 40 mg twice daily

	==Renal Dose Adjustments==		==Renal Dose Adjustments==

	There are no specific renal dose adjustments recommended based on estimated glomerular filtration rate (eGFR) for pantoprazole; however, caution should be exercised in severe renal impairment.		There are no specific renal dose adjustments recommended based on the estimated glomerular filtration rate (eGFR) for pantoprazole; however, caution should be exercised in severe renal impairment.

	==Side Effects==		==Side Effects==
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	\| Flatulence		\| Flatulence
	\|-		\|-
	\| rowspan=5 \| '''Serious Side Effects		\| rowspan=5 \| '''Serious Side Effects of long-term use
	\|-		\|-
	\| ~~Bone~~ fractures		\| Osteoporosis-related fractures
	\|-		\|-
	\| Clostridium difficile infection		\| Clostridium difficile infection
	\|-		\|-
	\| ~~Anaphylaxis~~		\| Low blood magnesium and Vit B12
	\|-		\|-
	\| ~~Vitamin B12 deficiency~~		\| Acute Interstitial Nephritis
	\|}		\|}
	==Pharmacokinetics==		==Pharmacokinetics==
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	==Drug Precautions==		==Drug Precautions==

	Pregnancy: ~~Pantoprazole should be used during pregnancy only if clearly needed, as its safety has not been established.~~		Pregnancy: avoid unless the potential benefit outweighs risk

	Breastfeeding: ~~It is not known whether pantoprazole passes into breast milk; caution is advised.~~		Breastfeeding: void unless the potential benefit outweighs risk

	Children and Elderly: Use in children over 5 years is generally safe; elderly patients may require monitoring due to the potential increased risk of side effects.		Children and Elderly: Use in children over 5 years is generally safe; elderly patients may require monitoring due to the potential increased risk of side effects such as bone fractures, kidney problems, and Clostridium difficile infection.

	==Monitoring Items==		==Monitoring Items==
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	==Drug Interactions==		==Drug Interactions==

	Drug Interactions: Pantoprazole ~~may interact~~ with medications such as warfarin, ~~methotrexate~~, and certain ~~antifungals~~. It can affect the ~~absorption~~ of ~~drugs that require an acidic environment~~.		Drug Interactions: can interact with other medications primarily through two mechanisms:
			*Alteration of Gastric pH: Pantoprazole increases gastric pH, which can affect the solubility and absorption of drugs that require an acidic environment for optimal absorption. For example, drugs like ketoconazole and atazanavir have significantly reduced bioavailability when taken with PPIs due to this pH alteration.
			*Inhibition of Cytochrome P450 Enzymes: which can lead to increased plasma concentrations of drugs metabolized by these pathways. This is particularly relevant for medications such as warfarin, clopidogrel, and certain antiepileptics like phenytoin.
			*Methotrexate: Pantoprazole can affect the pharmacokinetics of methotrexate, potentially leading to increased toxicity.
			Summary of Key Drug Interactions:
			*Clopidogrel: Reduced effectiveness; increased cardiovascular risk
			*Warfarin: Increased anticoagulation effect; monitor INR
			*Methotrexate: Increased toxicity risk; monitor renal function
			*Phenytoin: Altered metabolism; monitor drug levels.
			*Atazanavir: Reduced bioavailability; consider alternatives

	==FAQ==		==FAQ==
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	'''How should I take the tablet?		'''How should I take the tablet?

	Take pantoprazole before meals, swallowing the tablet whole without crushing or chewing		Take pantoprazole on an empty stomach, ideally 30 minutes before meals, swallowing the tablet whole without crushing or chewing. Consuming them with food may reduce their effectiveness.

	'''What should I avoid while taking?		'''What should I avoid while taking?

	~~Avoid~~ highly acidic foods and ~~grapefruit~~		Limit or avoid highly acidic foods and drinks like coffee and soda

	'''What happens if I miss a dose?		'''What happens if I miss a dose?

	Take as soon as remembered unless close to next dose; do not double up on doses		Take as soon as remembered unless close to next dose; do not double up on doses

Calise at 06:48, 6 January 2025

2025-01-06T06:48:36Z

← Older revision		Revision as of 02:48, 6 January 2025
Line 7:		Line 7:
	==Drug Class==		==Drug Class==

	Proton Pump Inhibitor (PPI) ~~12345678~~		Proton Pump Inhibitor (PPI)

	==Common Strengths of Pantoprazole tablet==		==Common Strengths of Pantoprazole tablet==

Calise at 06:48, 6 January 2025

2025-01-06T06:48:15Z

← Older revision		Revision as of 02:48, 6 January 2025
Line 7:		Line 7:
	==Drug Class==		==Drug Class==

	Proton Pump Inhibitor (PPI)		Proton Pump Inhibitor (PPI) 12345678

	==Common Strengths of Pantoprazole tablet==		==Common Strengths of Pantoprazole tablet==

Calise at 06:34, 6 January 2025

2025-01-06T06:34:17Z

← Older revision		Revision as of 02:34, 6 January 2025
Line 7:		Line 7:
	==Drug Class==		==Drug Class==

	Proton Pump Inhibitor (PPI)		Proton Pump Inhibitor (PPI)

			==Common Strengths of Pantoprazole tablet==

			Pantoprazole tablet are available in the following strengths:

			*20 mg delayed-release oral tablets

			*40 mg delayed-release oral tablets

			*Intravenous (IV) formulation for injection

			==Drug Trade Name of Pantoprazole tablet==

			PANTOLOC

			==Drug Usage==

			Pantoprazole is used for:

			Healing of erosive esophagitis (EE)

			Management of erosive esophagitis due to GERD

			Treatment of gastroesophageal reflux disease (GERD)

			Prevention of gastric damage in patients taking NSAIDs

			==Mechanism of Action==

			Inhibits (H+/K+ )-ATPase enzyme in the gastric parietal cells, blocking gastric acid production in the stomach

			==Route of Administration==

			Oral and intravenously (injection)

			==Dosages ==

			For adults and children aged 12 years and older, the typical dosage is:

			GERD: 40 mg once daily for up to 8 weeks

			==Renal Dose Adjustments==

			There are no specific renal dose adjustments recommended based on estimated glomerular filtration rate (eGFR) for pantoprazole; however, caution should be exercised in severe renal impairment.

			==Side Effects==

			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan=6 \| '''Common Side Effects
			\|-
			\| Diarrhea
			\|-
			\| Abdominal pain
			\|-
			\| Nausea
			\|-
			\| Vomiting
			\|-
			\| Flatulence
			\|-
			\| rowspan=5 \| '''Serious Side Effects
			\|-
			\| Bone fractures
			\|-
			\| Clostridium difficile infection
			\|-
			\| Anaphylaxis
			\|-
			\| Vitamin B12 deficiency
			\|}
			==Pharmacokinetics==

			Onset Time: Effects can be observed within 2 to 3 hours after oral administration.

			Duration of Action: The acid-suppressive effect lasts approximately 24 hours.

			==Drug Precautions==

			Pregnancy: Pantoprazole should be used during pregnancy only if clearly needed, as its safety has not been established.

			Breastfeeding: It is not known whether pantoprazole passes into breast milk; caution is advised.

			Children and Elderly: Use in children over 5 years is generally safe; elderly patients may require monitoring due to the potential increased risk of side effects.

			==Monitoring Items==

			Regular monitoring of magnesium and vitamin B12 levels

			==Drug Interactions==

			Drug Interactions: Pantoprazole may interact with medications such as warfarin, methotrexate, and certain antifungals. It can affect the absorption of drugs that require an acidic environment.

			==FAQ==

			'''How should I take the tablet?

			Take pantoprazole before meals, swallowing the tablet whole without crushing or chewing

			'''What should I avoid while taking?

			Avoid highly acidic foods and grapefruit

			'''What happens if I miss a dose?

			Take as soon as remembered unless close to next dose; do not double up on doses

Calise: Created page with "Category: DrugsCategory: Proton Pump Inhibitors (PPI) '''Gastrointestinal Drug''' '''Drug class: Proton Pump Inhibitors (PPI)''' '''Pantoprazole''' (中文: 泮托拉唑) ==Drug Class== Proton Pump Inhibitor (PPI)"

2025-01-06T06:26:01Z

Created page with "Category: Drugs Category: Proton Pump Inhibitors (PPI) '''Gastrointestinal Drug''' '''Drug class: Proton Pump Inhibitors (PPI)''' '''Pantoprazole''' (中文: 泮托拉唑) ==Drug Class== Proton Pump Inhibitor (PPI)"

New page

[[Category: Drugs]][[Category: Proton Pump Inhibitors (PPI)]][[:Category: Gastrointestinal Drug | '''Gastrointestinal Drug''']]

'''Drug class: [[:Category: Proton Pump Inhibitors (PPI) | Proton Pump Inhibitors (PPI)]]'''

'''Pantoprazole''' (中文: [[泮托拉唑]])

==Drug Class==

Proton Pump Inhibitor (PPI)