Paroxetine - Revision history

Zeki at 05:45, 5 August 2024

2024-08-05T05:45:54Z

← Older revision		Revision as of 01:45, 5 August 2024
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	\| Discontinuation syndrome if stopped abruptly		\| Discontinuation syndrome if stopped abruptly
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			==Pharmacokinetics==
			*Metabolism: Hepatic via mainly CYP2D6 and CYP3A4
			*Elimination: Primarily renal
			*Half-life: approximately 21 hours
			*Onset: 4 - 6 weeks for full antidepressant effect

			==Drug Precautions==
			'''Pregnancy

			Use only if the potential benefit justifies the risk to the fetus

			'''Breastfeeding

			Present in breast milk

			'''Children and Elderly

			Not approved for use in pediatric patients. Lower doses are recommended for elderly due to increased sensitivity to side effects

			'''Monitoring Requirements
			*Monitor for suicidal thoughts, especially in young adults
			*Monitor for serotonin syndrome, especially when combined with other serotonergic drugs
			*Regularly assess liver function and electrolyte levels
			*Suicidal thoughts, serotonin syndrome, liver function, electrolyte levels

			'''Drug Interactions
			*Contraindicated with thioridazine due to risk of serotonin syndrome and QT prolongation
			*Caution with other serotonergic drugs, NSAIDs, anticoagulants, and drugs affecting CYP2D6 metabolism

			==FAQ==
			'''How Should I Take the Tablet?

			Take orally with or without food, usually once daily in the morning.

			'''What Should I Avoid While Taking?

			Avoid alcohol and activities requiring mental alertness until you know how the tablet affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Zeki at 05:24, 5 August 2024

2024-08-05T05:24:31Z

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 | Constipation or diarrhea
 |-
-| Dry Mouth
+| Dry Mouth: Using sugar-free gum or candy can help alleviate dry mouth

Zeki at 04:29, 5 August 2024

2024-08-05T04:29:53Z

← Older revision		Revision as of 00:29, 5 August 2024
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	'''Paroxetine (SEROXAT)'''（中文：[[帕羅西汀]]）		'''Paroxetine (SEROXAT)'''（中文：[[帕羅西汀]]）
			==Common Strengths of Paroxetine==
			Paroxetine are available in the following strengths:
			*10 mg, 20 mg, 30 mg, 40 mg tablets
			*12.5 mg, 25 mg, 37.5 mg, controlled-release tablets
			*10 mg/5 mL oral suspension
			*10 mg/mL oral drops

			==Drug Trade Names of Paroxetine==
			SEROXAT

			==Drug Usage==
			*Major depressive disorder
			*Obsessive-compulsive disorder (OCD)
			*Panic disorder
			*Social anxiety disorder
			*Generalized anxiety disorder
			*Post-traumatic stress disorder (PTSD)

			==Mechanism of Action==
			Paroxetine is a selective serotonin reuptake inhibitor (SSRI). It works by increasing serotonin levels in the brain by inhibiting its reuptake into presynaptic neurons, thereby enhancing serotonergic acitivity.

			==Route of Administration==
			Oral

			==Dosages==
			*Depression: 20 mg/day initially, may increase to 50 mg/day maximum
			*Obsessive-compulsive disoreder (OCD): 20 mg/day initially, may increase to 60 mg/ day maximum
			*Panic disorder: 10 mg/day initially, may increase to 60 mg/day maximum
			*Social anxiety disorder, generalized anxiety disorder, Post-traumatic stress disorder (PTSD): 20 mg/day initially, may increase to 50 mg/day maximum

			Renal dose based on eGFR:
			*For severe renal impairment (eGFR ≥ 30 mL/min):
			**Immediate-release tablets: 10 mg/day initially, may titrate up to 40 mg/day maximum
			**Controlled-release tablets: 12.5 mg/day initially, may titrate up to 50 mg/day maximum

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="12" \| '''Common
			\| '''These side effects are generally mild and often subside as the body adjusts to the medication.'''
			\|-
			\| Nausea: Often mitigated by taking the medication with food
			\|-
			\| Headaches: Drinking plenty of fluids and resting can help; avoid excessive alcohol consumption
			\|-
			\| Insomnia: Taking fluoxetine in the morning may reduce sleep disturbances
			\|-
			\| Fatigue or Weakness: Resting and avoiding activities that require alertness, such as driving
			\|-
			\| Sexual Dysfunction: This includes decreased libido and difficulty achieving orgasm
			\|-
			\| Constipation or diarrhea
			\|-
			\| Dry Mouth

Zeki: Created page with "Category: DrugsCategory: Selective serotonin reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Selective..."

2024-08-05T03:47:40Z

Created page with "Category: Drugs Category: Selective serotonin reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Selective..."

New page

[[Category: Drugs]][[Category: Selective serotonin reuptake inhibitor]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Selective serotonin reuptake inhibitor | Selective Serotonin Reuptake Inhibitor]]

'''Paroxetine (SEROXAT)'''（中文：[[帕羅西汀]]）