Pericyazine - Revision history

Zeki: /* FAQ */

2024-08-01T01:06:02Z

FAQ

← Older revision		Revision as of 21:06, 31 July 2024
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	Take orally, usually twice daily in the morning and evening		Take orally, usually twice daily in the morning and evening

	What Should I Avoid While Taking?		'''What Should I Avoid While Taking?

	Avoid alcohol, driving, or operating machinery until you know how it affects you. Avoid excessive sun exposure		Avoid alcohol, driving, or operating machinery until you know how it affects you. Avoid excessive sun exposure

	What Happens if I Miss a Dose?		'''What Happens if I Miss a Dose?

	Take as soon as you remember. If it is close to the next dose, skip the missed dose. Do not double up.		Take as soon as you remember. If it is close to the next dose, skip the missed dose. Do not double up.

Zeki at 08:06, 29 July 2024

2024-07-29T08:06:24Z

Show changes

Zeki at 02:16, 25 July 2024

2024-07-25T02:16:47Z

← Older revision		Revision as of 22:16, 24 July 2024
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	[[Category: Drugs]][[Category: ~~typical antipsychotic~~ ]]		[[Category: Drugs]][[Category: Conventional Antipsychotic]]
	'''Pericyazine'''(中文:[[哌氰嗪]]) is a typical antipsychotic medication. Periciazine is indicated:		'''Pericyazine'''(中文:[[哌氰嗪]]) is a typical antipsychotic medication. Periciazine is indicated:
	#In adults with schizophrenia or other psychoses, for the treatment of symptoms or prevention of relapse.		#In adults with schizophrenia or other psychoses, for the treatment of symptoms or prevention of relapse.

Helen at 04:02, 3 November 2020

2020-11-03T04:02:01Z

← Older revision		Revision as of 00:02, 3 November 2020
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	[[Category: Drugs]][[Category: typical antipsychotic ]]		[[Category: Drugs]][[Category: typical antipsychotic ]]
	'''Pericyazine'''(中文:[[ ]]) is a typical antipsychotic medication. Periciazine is indicated:		'''Pericyazine'''(中文:[[哌氰嗪]]) is a typical antipsychotic medication. Periciazine is indicated:
	#In adults with schizophrenia or other psychoses, for the treatment of symptoms or prevention of relapse.		#In adults with schizophrenia or other psychoses, for the treatment of symptoms or prevention of relapse.
	#As a short-term adjuntive management of severe anxiety, and violent or dangerously impulseive behavior.		#As a short-term adjuntive management of severe anxiety, and violent or dangerously impulseive behavior.

Helen: /* Drug Management */

2020-10-22T02:17:07Z

Drug Management

← Older revision		Revision as of 22:17, 21 October 2020
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	*An increased risk of ventricular arrhythmias – avoid concomitant use.		*An increased risk of ventricular arrhythmias – avoid concomitant use.
	\|}		\|}

			===Caution===
			*In those with renal dysfunction, epilepsy, Parkinson’s disease, hypothyroidism, cardiac failure and myasthenia gravis.
			*In patients with impaired liver
			*In patients with cardiovascular disorders, bradycardia, hypokalaemia or prolongation of QT, because of a risk of worsening of long QT-syndrome, which may also elevate the risk of tachycardia and sudden death.
			*Concomitant use with QT prolonging drugs should be avoided
			*In epileptics due to a possible lowering of the seizure threshold. The occurrence of convulsive seizures necessitates the discontinuation of treatment.

			===Contra-indications===
			Use of pericyazine should be avoided in individuals with:
			*CNS depression
			*Comatose states
			*Risk of angle-closure glaucoma
			*Parkinson’s disease
			*Phaeochromocytoma
			*Prostatic hypertrophy

			===Hepatic impairment===
			*Pericyazine is hepatotoxic; can precipitate coma.

			===Renal impairment===
			*Avoid in renal impairment.

			===Pregnancy===
			Should be avoided in pregnancy.

			===Breast-feeding===
			Use during breast feeding is not recommended.

			===Driving and skilled tasks===
			Drivers and machine operators should be told about the risk of drowsiness with this medication especially at the start of treatment. Affected patients should not drive or operate machinery.

			== FAQ ==
			===How should I take the tablet?===
			You will be prescribed the lowest dose needed to control your symptoms. Take with food. Food reduces irritation.
			===What should I avoid while taking?===
			Avoid drinking alcohol while taking pericyazine because it may enhance the side effects of sedation.

			Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
			=== What happen if I overdose? ===
			Contact your primary care doctor.
			If emergency situation, call 999
			=== What happen if I miss a dose? ===
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Helen at 02:13, 22 October 2020

2020-10-22T02:13:16Z

← Older revision		Revision as of 22:13, 21 October 2020
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	There is high inter-patient variability		There is high inter-patient variability
			\|}

			==Drug Management==
			===Monitoring===
			*Full blood count, serum potassium, and liver function test is required at the start of therapy, and then annually thereafter.
			*Fasting blood glucose should be monitored at start of therapy, at 4-6 months, and then yearly
			*Blood pressure and BMI
			*Patients on long-term treatment should receive regular eye examinations.
			*Careful monitoring is required in the elderly who are particularly susceptible to postural hypotension, sedation, and extrapyramidal effects, chronic constipation, and possible prostatic hypertrophy.

			===Drug interaction===
			The metabolism of pericyazine is mediated by the cytochrome P450 system, particularly the isoenzymes CYP3A4 and CYP2D6. Therefore, there is the potential for interactions between pericyazine and other drugs that induce, inhibit, or act as a substrate for these isoenzymes, resulting in altered plasma pericyazine concentrations.

			{\| class="wikitable"
			!Drugs given with pericyazine
			!Potential Effect
			\|-
			\|style="text-align: left"\|
			*CNS-depressant drugs including alcohol, hypnotics, anxiolytics, sedative H1 antihistamines, central antihypertensives, baclofen, thalidomide and opioids.
			\|
			Potentiates the sedative effect.
			Impaired vigilance may make it dangerous to drive or use machines.
			\|-
			\|style="text-align: left"\|
			*Lithium
			\|Might increase the risk of lithium poisoning or neuroleptic malignant syndrome. Regular monitoring of serum lithium should be performed.
			\|-
			\|style="text-align: left"\|
			*Tricyclic antidepressants such as amitriptyline, a CYP2D6 substrate, and pericyazine is potent inhibitor of CYP2D6.
			\|Metabolism and elimination of tricyclics significantly decreased, increased toxicity such as anticholinergic and cardiovascular side effects.
			\|-
			\|style="text-align: left"\|
			*Levodopa
			\|In theory, antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic.
			\|-
			\|style="text-align: left"\|
			*Drugs that prolong the QT interval e.g. amiodarone, sotalol, quinidine
			*Drugs which induce bradycardia e.g. diltiazem, verapamil
			*Drugs which can cause hypokalaemia such as diuretics e.g. frusemide
			\|
			*An increased risk of ventricular arrhythmias – avoid concomitant use.
	\|}		\|}

Helen: /* Pharmacokinetics */

2020-10-22T02:08:26Z

Pharmacokinetics

← Older revision		Revision as of 22:08, 21 October 2020
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	\|		\|
	It is excreted in the urine and faeces.		It is excreted in the urine and faeces.

	The elimination half-life is approximately 12 hours.		The elimination half-life is approximately 12 hours.

	There is high inter-patient variability		There is high inter-patient variability
	\|}		\|}

Helen at 02:08, 22 October 2020

2020-10-22T02:08:11Z

@@ Line 99: / Line 99: @@
 *Owing to contact skin hypersensitivity should avoid direct contact with the drug,
 *Because of the risk of photosensitization, patients should be advised to avoid exposure to direct sunlight and that retinal changes may occur.
 |}

Helen: /* Side Effects */

2020-10-22T02:06:23Z

Side Effects

← Older revision		Revision as of 22:06, 21 October 2020
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	\|		\|
	*Jaundice occurs in a very small percentage of patients. Treatment should be withheld on the development of jaundice		*Jaundice occurs in a very small percentage of patients. Treatment should be withheld on the development of jaundice
			\|-
	\|Cardiovascular:		\|Cardiovascular:
	\|		\|

Helen: /* Side Effects */

2020-10-22T02:06:09Z

Side Effects

@@ Line 64: / Line 64: @@
 *Drowsiness is common at the start of treatment, but this effect usually eases off within a few days.
 *Impaired psychomotor activity is a frequent side-effect.
 |}