Phenobarbitone - Revision history

Helen: /* Drug interaction */

2020-10-12T07:09:09Z

Drug interaction

← Older revision		Revision as of 03:09, 12 October 2020
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	\|		\|
	Antibiotics:		Antibiotics:

	METRONIDAZOLE, DOXYCYCLINE,		METRONIDAZOLE, DOXYCYCLINE,
	CHLORAMPHENICOL, RIFAMPICIN		CHLORAMPHENICOL, RIFAMPICIN

2020-10-12T07:06:46Z

Drug Names

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	\|Phenobarbitone Tablet 60mg		\|Phenobarbitone Tablet 60mg
	\|PHEN09		\|PHEN09
			\|P1S1S3
			\|-
			\|Phenobarbitone sodium 200mg/ml injection
			\|PHEN10
	\|P1S1S3		\|P1S1S3
	\|}		\|}

2020-10-09T03:09:16Z

FAQ

← Older revision		Revision as of 23:09, 8 October 2020
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	If emergency situation, call 999		If emergency situation, call 999
	=== What happen if I miss a dose? ===		=== What happen if I miss a dose? ===
	Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the		Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

2020-10-09T02:45:18Z

← Older revision		Revision as of 22:45, 8 October 2020
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	[[Category: Drugs]] [[Category: ~~Anticonvulsant medication~~]]		[[Category: Drugs]] [[Category: Seizures]]

	'''Phenobarbital'''(中文: [[苯巴比妥]]), also known as phenobarbitone or phenobarb, is a medication of the barbiturate type. It is used to control all forms of epilepsy except absence seizures. It is also used as part of the emergency management of acute seizures including status epilepticus.		'''Phenobarbital'''(中文: [[苯巴比妥]]), also known as phenobarbitone or phenobarb, is a medication of the barbiturate type. It is used to control all forms of epilepsy except absence seizures. It is also used as part of the emergency management of acute seizures including status epilepticus.

2020-10-08T02:02:18Z

Side Effects

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	{\|class="wikitable"		{\|class="wikitable"
	!style="text-align: left"\| ~~'''~~Very common~~'''~~ (>10% incidence)		!style="text-align: left"\| Very common (>10% incidence)
	\|		\|
	*sedation		*sedation
	*hypnosis		*hypnosis
	\|-		\|-
	!style="text-align: left"\| ~~'''~~Common~~'''~~ (1-10% incidence)		!style="text-align: left"\| Common (1-10% incidence)
	\|		\|
	*Central nervous systems effects, such as dizziness, nystagmus and ataxia		*Central nervous systems effects, such as dizziness, nystagmus and ataxia
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	*At high doses typical barbiturate-induced respiratory depression may become severe		*At high doses typical barbiturate-induced respiratory depression may become severe
	\|-		\|-
	!style="text-align: left"\| ~~'''~~Rare~~'''~~ (<0.1% of incidence)		!style="text-align: left"\| Rare (<0.1% of incidence)
	\|		\|
	*Stevens-Johnson syndrome		*Stevens-Johnson syndrome

2020-10-08T01:48:50Z

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	===Epilepsy and driving===		===Epilepsy and driving===
	Driving by patients with epilepsy is generally regulated. Also, antiepileptic drugs may produce CNS-related adverse effects, including dizziness and drowsiness, that could impair a patient’s ability to drive a vehicle or operate machinery, particularly during the initial stages of therapy.		Driving by patients with epilepsy is generally regulated. Also, antiepileptic drugs may produce CNS-related adverse effects, including dizziness and drowsiness, that could impair a patient’s ability to drive a vehicle or operate machinery, particularly during the initial stages of therapy.

			== FAQ ==
			=== How should I use the patch? ===
			Take this medication with or without food, usually once daily at bedtime for seizure control. Take with food if stomach upset occurs.
			=== What should I avoid while using? ===
			Avoid abruptly discontinue the medication. Avoid alcohol.
			=== What happen if I overdose? ===
			Contact your primary care doctor.
			If emergency situation, call 999
			=== What happen if I miss a dose? ===
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the

2020-10-08T01:47:25Z

Drug Management

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	===Contra-indication===		===Contra-indication===
	*In those with severe respiratory depression		*In those with severe respiratory depression


	===Hepatic impairment===		===Hepatic impairment===

2020-10-08T01:47:06Z

Drug Management

← Older revision		Revision as of 21:47, 7 October 2020
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	\|Phenobarbitone accelerates the metabolism of THYROID HORMONES (may increase dosage of thyroxine in hypothyroidism)		\|Phenobarbitone accelerates the metabolism of THYROID HORMONES (may increase dosage of thyroxine in hypothyroidism)
	\|}		\|}

			===Caution===
			*Avoid in acute porphyria
			*Used with care in children and in elderly or debilitated patients
			*In those in acute pain
			*In those with depressive disorders
			*History of alcohol abuse
			*History of drug abuse
			*Use with caution in patients with impaired hepatic, renal, or respiratory function
			*Consider vit D supplement in patients who are immobilized for long periods or who have inadequate sun exposure or dietary intake of calcium.
			*Avoid abrupt withdrawal (dependence with prolonged use)

			===Contra-indication===
			*In those with severe respiratory depression


			===Hepatic impairment===
			May precipitate coma. Avoid in severe impairment

			===Renal impairment===
			Use with caution

			===Pregnancy===
			The dose should be monitored carefully during pregnancy and after birth, and adjustments made on a clinical basis.

			===Breast-feeding===
			Use during breast feeding is not recommended.

			===Epilepsy and driving===
			Driving by patients with epilepsy is generally regulated. Also, antiepileptic drugs may produce CNS-related adverse effects, including dizziness and drowsiness, that could impair a patient’s ability to drive a vehicle or operate machinery, particularly during the initial stages of therapy.

2020-10-08T01:45:16Z

Drug interaction

← Older revision		Revision as of 21:45, 7 October 2020
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	METRONIDAZOLE, DOXYCYCLINE,		METRONIDAZOLE, DOXYCYCLINE,
	CHLORAMPHENICOL, RIFAMPICIN		CHLORAMPHENICOL, RIFAMPICIN
	\|Phenobarbitone accelerates their metabolism of metronidazole		\|
			Phenobarbitone accelerates their metabolism of metronidazole
	(reduced effect)		(reduced effect)
	\|-		\|-
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	*APIXABAN		*APIXABAN
	*RIVAROXABAN		*RIVAROXABAN
	\|-
	\|Phenobarbitone possibly reduces plasma concentration, recommends to monitor signs of thrombosis		\|Phenobarbitone possibly reduces plasma concentration, recommends to monitor signs of thrombosis
	\|-		\|-

2020-10-08T01:44:39Z

Drug interaction

← Older revision		Revision as of 21:44, 7 October 2020
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	METRONIDAZOLE, DOXYCYCLINE,		METRONIDAZOLE, DOXYCYCLINE,
	CHLORAMPHENICOL, RIFAMPICIN		CHLORAMPHENICOL, RIFAMPICIN
	\|		\|Phenobarbitone accelerates their metabolism of metronidazole
	Phenobarbitone accelerates their metabolism of metronidazole
	(reduced effect)		(reduced effect)
	\|-		\|-