Piroxicam - Revision history

Helen: /* Administration in children */

2020-10-14T01:56:48Z

Administration in children

← Older revision		Revision as of 21:56, 13 October 2020
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	\|Less than 15 kg		\|Less than 15 kg
	\|5 mg once daily		\|5 mg once daily
	\|~~Aged 1 month~~ to ~~17 years; Oral: 0.5~~ to 1 mg/kg ~~twice~~ daily.		\|-
			\|15 to 25 kg
			\|10 mg once daily
			\|-
			\|26 to 45 kg
			\|15 mg once daily
			\|-
			\|46 kg or over
			\|20 mg once daily
	\|}		\|}

	*Less than 15 kg: 5 mg once daily
	*15 to 25 kg: 10 mg once daily
	*26 to 45 kg: 15 mg once daily
	*46 kg or over: 20 mg once daily

	==Side Effects==		==Side Effects==

Helen at 01:54, 14 October 2020

2020-10-14T01:54:18Z

← Older revision		Revision as of 21:54, 13 October 2020
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	\|Oral : 20 mg once daily		\|Oral : 20 mg once daily
	Piroxicam has been given in similar doses as a rectal suppository or on a short-term basis by intramuscular injection. Piroxicam is one of the few NSAIDs that can be given parenteral routes.		Piroxicam has been given in similar doses as a rectal suppository or on a short-term basis by intramuscular injection. Piroxicam is one of the few NSAIDs that can be given parenteral routes.


	\|-		\|-
	!Pain / inflammatory		!Pain / inflammatory
	\|0.5% or 1% piroxicam gel is applied three to four times daily; treatment should be reviewed after 4 weeks		\|0.5% or 1% piroxicam gel is applied three to four times daily; treatment should be reviewed after 4 weeks
	\|-
	~~!Dysmenorrhea~~
	~~\|''Oral'' : 75 mg daily~~
	\|}		\|}
	~~In the treatment of rheumatic disorders~~
	~~Oral: 20 mg once daily.~~

	~~Piroxicam has been given in similar doses as a rectal suppository or on a short-term basis by intramuscular injection. Piroxicam is one of the few NSAIDs that can be given parenteral routes.~~

	~~For local treatment of painful or inflammatory conditions, 0.5% or 1% piroxicam gel is applied three or four times daily; treatment should be reviewed after 4 weeks.~~

	===Administration in children===		===Administration in children===
	Piroxicam has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:		Piroxicam has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:
			{\| class="wikitable"
			\|Less than 15 kg
			\|5 mg once daily
			\|Aged 1 month to 17 years; Oral: 0.5 to 1 mg/kg twice daily.
			\|}

	*Less than 15 kg: 5 mg once daily		*Less than 15 kg: 5 mg once daily
	*15 to 25 kg: 10 mg once daily		*15 to 25 kg: 10 mg once daily

Helen: /* Dosage */

2020-10-14T01:50:27Z

Dosage

@@ Line 20: / Line 20: @@
 ==Dosage==
 In the treatment of rheumatic disorders
 Oral:  20 mg once daily.

Helen: /* Dosage */

2020-10-12T04:43:58Z

Dosage

← Older revision		Revision as of 00:43, 12 October 2020
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	==Dosage==		==Dosage==
	~~===~~In the treatment of rheumatic disorders~~===~~		In the treatment of rheumatic disorders
	Oral: 20 mg once daily.		Oral: 20 mg once daily.

Helen at 04:43, 12 October 2020

2020-10-12T04:43:07Z

← Older revision		Revision as of 00:43, 12 October 2020
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	[[Category: Drugs]] [[Category:Non-~~steroidal anti-inflammatory drug~~ (NSAID) ]]		[[Category: Drugs]] [[Category :Non-opioid Analgesic (NSAID) ]]
	'''Piroxicam''' is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, sulindac is an analgesic, anti-inflammatory and antipyretic.		'''Piroxicam'''(:中文 [[吡羅昔康 ]]) is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, sulindac is an analgesic, anti-inflammatory and antipyretic.
	It has been used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis including juvenile idiopathic arthritis, in soft-tissue disorders, in acute gout and in postoperative pain.		It has been used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis including juvenile idiopathic arthritis, in soft-tissue disorders, in acute gout and in postoperative pain.

			==Drug name==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名
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	\|-		\|-
	\|Piroxicam Capsule 10mg		\|Piroxicam Capsule 10mg
	\|		\|PIRO01
	\|P1S1S3		\|P1S1S3
	\|}		\|}

Ctol2: /* Drug Management */

2020-09-30T09:19:07Z

Drug Management

← Older revision		Revision as of 05:19, 30 September 2020
Line 51:		Line 51:

	==Drug Management==		==Drug Management==
	~~'''~~Monitoring		===Monitoring===
	*Regular physical examination to detect edema and signs of central nervous side effects.		*Regular physical examination to detect edema and signs of central nervous side effects.
	*Blood pressure checks will reveal development of hypertension		*Blood pressure checks will reveal development of hypertension
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	This is particularly important if Indomethacin is given together with an ACE inhibitor or with potassium-sparing diuretic (e.g. spironolactone), because these combinations can lead to hyperkalemia and/or serious kidney failure.		This is particularly important if Indomethacin is given together with an ACE inhibitor or with potassium-sparing diuretic (e.g. spironolactone), because these combinations can lead to hyperkalemia and/or serious kidney failure.

	~~'''~~Drug interaction		===Drug interaction===
	*Increases the blood thinning effects of warfarin because it displaces them from their plasma protein binding and increases their free concentrations in the bloodstream.		*Increases the blood thinning effects of warfarin because it displaces them from their plasma protein binding and increases their free concentrations in the bloodstream.
	*Increase the risk of adverse effects of lithium, methotrexate and cardiac glycosides by lowering their excretion via the kidneys.		*Increase the risk of adverse effects of lithium, methotrexate and cardiac glycosides by lowering their excretion via the kidneys.
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	*Hypertension		*Hypertension

	~~'''~~Contraindication:		===Contraindication===
	*it should be avoided by children under 12		*it should be avoided by children under 12
	*people with liver problems		*people with liver problems
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	*Can lead to onset of new hypertension or worsening of pre-existing hypertension		*Can lead to onset of new hypertension or worsening of pre-existing hypertension

	~~'''~~Precautions		===Precautions===
	Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.		Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.


	== FAQ ==		== FAQ ==

Ctol2 at 09:18, 30 September 2020

2020-09-30T09:18:32Z

← Older revision		Revision as of 05:18, 30 September 2020
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	[[Category: Drugs]] [[Category:Non-steroidal anti-inflammatory drug (NSAID) ]]		[[Category: Drugs]] [[Category:Non-steroidal anti-inflammatory drug (NSAID) ]]
			'''Piroxicam''' is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, sulindac is an analgesic, anti-inflammatory and antipyretic.
	~~==Introduction==~~
	Piroxicam, is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, sulindac is an analgesic, anti-inflammatory and antipyretic.
	It has been used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis including juvenile idiopathic arthritis, in soft-tissue disorders, in acute gout and in postoperative pain.		It has been used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis including juvenile idiopathic arthritis, in soft-tissue disorders, in acute gout and in postoperative pain.

	~~==Mechanism of Action==~~
	~~Anti-inflammatory agent~~
	~~Non-steroidal anti-inflammatory drug (NSAID)~~
	~~Non-selective COX inhibitor~~


	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名
	!HA Code 藥物代碼		!HA Code 藥物代碼
	!~~Classification藥物分類~~		!Classification 藥物分類
	\|-		\|-
	\|Piroxicam Capsule 10mg		\|Piroxicam Capsule 10mg
Line 21:		Line 12:
	\|}		\|}

			==Mechanism of Action==
			Anti-inflammatory agent
			Non-steroidal anti-inflammatory drug (NSAID)
			Non-selective COX inhibitor

	==Dosage==		==Dosage==
	~~'''~~In the treatment of rheumatic disorders:		===In the treatment of rheumatic disorders===

	Oral: 20 mg once daily.		Oral: 20 mg once daily.

Line 31:		Line 25:
	For local treatment of painful or inflammatory conditions, 0.5% or 1% piroxicam gel is applied three or four times daily; treatment should be reviewed after 4 weeks.		For local treatment of painful or inflammatory conditions, 0.5% or 1% piroxicam gel is applied three or four times daily; treatment should be reviewed after 4 weeks.

	~~'''~~Administration in children		===Administration in children===

	Piroxicam has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:		Piroxicam has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:
	*Less than 15 kg: 5 mg once daily		*Less than 15 kg: 5 mg once daily
Line 42:		Line 35:
	As with other NSAIDs the principal side effects include:		As with other NSAIDs the principal side effects include:

	*Digestive complaints like nausea, heartburn, ~~diarrhoea~~ and bleeds or ulceration of the stomach		*Digestive complaints like nausea, heartburn, diarrhea and bleeds or ulceration of the stomach
	*Headache, dizziness, depression, drowsiness, insomnia,		*Headache, dizziness, depression, drowsiness, insomnia,
	*Hearing disturbances such as tinnitus		*Hearing disturbances such as tinnitus
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	Compared to other NSAIDs it is more prone to causing gastrointestinal disturbances and serious skin reactions.		Compared to other NSAIDs it is more prone to causing gastrointestinal disturbances and serious skin reactions.


	==Pharmacokinetics==		==Pharmacokinetics==

Helen: /* Dosage */

2020-09-29T07:36:15Z

Dosage

← Older revision		Revision as of 03:36, 29 September 2020
Line 30:		Line 30:

	For local treatment of painful or inflammatory conditions, 0.5% or 1% piroxicam gel is applied three or four times daily; treatment should be reviewed after 4 weeks.		For local treatment of painful or inflammatory conditions, 0.5% or 1% piroxicam gel is applied three or four times daily; treatment should be reviewed after 4 weeks.

			'''Administration in children

			Piroxicam has been used in children with juvenile idiopathic arthritis. The following doses, given according to body-weight, are recommended for children aged 6 years and over:
			*Less than 15 kg: 5 mg once daily
			*15 to 25 kg: 10 mg once daily
			*26 to 45 kg: 15 mg once daily
			*46 kg or over: 20 mg once daily

			==Side Effects==
			As with other NSAIDs the principal side effects include:

			*Digestive complaints like nausea, heartburn, diarrhoea and bleeds or ulceration of the stomach
			*Headache, dizziness, depression, drowsiness, insomnia,
			*Hearing disturbances such as tinnitus
			*High blood pressure, oedema
			*Skin reactions (including, albeit rarely, Stevens-Johnson syndrome and toxic epidermal necrolysis)
			*And rarely, kidney failure, pancreatitis and liver damage

			Compared to other NSAIDs it is more prone to causing gastrointestinal disturbances and serious skin reactions.


			==Pharmacokinetics==

			Piroxicam is well absorbed from the gastrointestinal tract and peak plasma concentrations occur 3 to 5 hours after an oral dose. It is more rapidly absorbed after intramuscular use. Piroxicam is 99% bound to plasma proteins. It has been detected in breast milk. It is metabolized in the liver and excreted mainly in the urine with smaller amounts in the faeces. Enterohepatic recycling occurs.

			Piroxicam has a long plasma elimination half-life of about 50 hours and steady-state concentrations are not reached for 7 to 12 days.

			==Drug Management==
			'''Monitoring
			*Regular physical examination to detect edema and signs of central nervous side effects.
			*Blood pressure checks will reveal development of hypertension
			*Periodic serum electrolyte (sodium, potassium, chloride) measurements
			*complete blood counts and
			*assessment of liver enzymes as well as creatinine (renal function) should be performed.

			This is particularly important if Indomethacin is given together with an ACE inhibitor or with potassium-sparing diuretic (e.g. spironolactone), because these combinations can lead to hyperkalemia and/or serious kidney failure.

			'''Drug interaction
			*Increases the blood thinning effects of warfarin because it displaces them from their plasma protein binding and increases their free concentrations in the bloodstream.
			*Increase the risk of adverse effects of lithium, methotrexate and cardiac glycosides by lowering their excretion via the kidneys.
			*Risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus or diuretics
			*Combination with antihypertensive drugs such as ACE inhibitors, sartans and diuretics can decrease their effectiveness as well as increase the risk for kidney toxicity.
			*Antihypertensive effects of ACEIs, beta blockers and diuretics may be reduced
			*Use of more than one NSAID together (including aspirin) should be avoided because of the increased risk of adverse effects.
			*It adds to the risk of gastrointestinal bleeding and ulceration when used with steroids, the SSRIs, the SNRI venlafaxaine, the antiplatelet clopidogrel, bisphosphonates or pentoxifylline.
			*Concomitant use of ritonavir and piroxicam may result in increased plasma concentrations of piroxicam.

			Many NSAIDs, but particularly indomethacin, cause lithium retention by reducing its excretion by the kidney. Thus, indomethacin users have an elevated risk of lithium toxicity. For patients taking lithium (e.g. for treatment of bipolar disorder), less toxic NSAIDs such as sulindac is preferred.

			All NSAIDs, including indomethacin, also increase plasma renin activity and aldosterone levels, and increase sodium and potassium retention. Vasopressin activity is also enhanced. Together these may lead to:
			*Edema (swelling due to fluid retention)
			*Hyperkaelemia (high potassium levels)
			*Hypernatremia (high sodium levels)
			*Hypertension

			'''Contraindication:
			*it should be avoided by children under 12
			*people with liver problems
			*Allergy to aspirin or other NSAIDs
			*History of allergic reactions (bronchospasm, rhinitis, urticaria) following the use of other NSAIDs such as aspirin
			*Contraindicated during pregnancy and in lactating women.
			*Active stomach and/or duodenal ulceration or gastrointestinal bleeding, or history of peptic ulcer disease
			*Inflammatory bowel disease such as Crohn’s disease or ulcerative colitis
			*Severe congestive heart failure (NYHA III/IV)
			*Severe chronic kidney disease (creatinine clearance <30 mi/min)
			*Caution in patients with severe, active bleeding such as cerebral hemorrhage
			*Caution in patients with fluid retention or heart failure
			*Caution in patients with Parkinson’s disease, epilepsy, psychotic disorders (sulindac may worsen these conditions)
			*Concurrent with potassium sparing diuretics
			*Can lead to onset of new hypertension or worsening of pre-existing hypertension

			'''Precautions
			Rectal use should be avoided in patients with a history of proctitis, haemorrhoids, or rectal bleeding.


			== FAQ ==
			==== How should I take the tablet? ====
			Should always be taken with food. Nearly all patients benefit from an ulcer protective drug (e.g. antacids, or famotidine 20mg or omeprazole 20 mg at bedtime).
			==== What should I avoid while taking? ====
			Avoid alcohol consumption.
			==== What happen if I overdose? ====
			Contact your primary care doctor.
			If emergency situation, call 999
			==== What happen if I miss a dose? ====
			Take it as soon as you
			remember. If it is near the time
			of the next dose, skip the missed
			dose. Take your next dose at the
			regular time. Do not double the
			dose to catch up.

Helen: /* Introduction */

2020-09-29T07:17:19Z

Introduction

@@ Line 4: / Line 4: @@
 Piroxicam, is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, sulindac is an analgesic, anti-inflammatory and antipyretic.
 It has been used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis including juvenile idiopathic arthritis, in soft-tissue disorders, in acute gout and in postoperative pain.
 {| class="wikitable"
@@ Line 13: / Line 19: @@
+|
 |P1S1S3

Helen: Created page with "Category: Drugs Category:Non-steroidal anti-inflammatory drug (NSAID) ==Introduction== Piroxicam, is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, su..."

2020-09-29T07:14:47Z

Created page with "Category: Drugs Category:Non-steroidal anti-inflammatory drug (NSAID) ==Introduction== Piroxicam, is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, su..."

New page

[[Category: Drugs]] [[Category:Non-steroidal anti-inflammatory drug (NSAID) ]]

==Introduction==
Piroxicam, is a nonsteroidal anti-inflammatory drug, an NSAID. As an NSAID, sulindac is an analgesic, anti-inflammatory and antipyretic.
It has been used in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, rheumatoid arthritis including juvenile idiopathic arthritis, in soft-tissue disorders, in acute gout and in postoperative pain.

{| class="wikitable"
!Generic Name 藥名
!HA Code 藥物代碼
!Classification藥物分類
|-
|Piroxicam Capsule 10mg
|
|P1S1S3