Prednisolone - Revision history

Helen: /* Side Effects */

2020-10-14T03:25:47Z

Side Effects

← Older revision		Revision as of 23:25, 13 October 2020
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	\|		\|
	\|-		\|-
	!\|Steroid-induced diabetes		!style="text-align: left"\| Steroid-induced diabetes
	\|		\|
	\|-		\|-
	!\|Osteoporosis, muscle wasting and weakness		!style="text-align: left"\| Osteoporosis, muscle wasting and weakness
	\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae		\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae
	\|-		\|-
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	\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia		\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia
	\|-		\|-
	!Neuropsychiatric side effects		!style="text-align: left"\| Neuropsychiatric side effects
	\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes		\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes
	\|-		\|-
	!Dermatological effects		!style="text-align: left"\| Dermatological effects
	\|easy bruising, impaired wound healing, and thinning of skin		\|easy bruising, impaired wound healing, and thinning of skin
	\|-		\|-
	!Ophthalmic effects		!style="text-align: left"\| Ophthalmic effects
	\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease		\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease

	\|}		\|}

Helen: /* Dosage */

2020-10-14T03:25:20Z

Dosage

← Older revision		Revision as of 23:25, 13 October 2020
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	\|-		\|-
	\|		\|
	\|Maintenance: usual range: 2.5 – 15 mg daily		\|Maintenance usual range: 2.5 – 15 mg daily
	\|}		\|}

Helen: /* Dosage */

2020-10-14T03:25:05Z

Dosage

← Older revision		Revision as of 23:25, 13 October 2020
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	\|initially, up to 10-20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months.		\|initially, up to 10-20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months.
	\|-		\|-
			\|
	\|Maintenance: usual range: 2.5 – 15 mg daily		\|Maintenance: usual range: 2.5 – 15 mg daily
	\|}		\|}

Helen: /* Dosage */

2020-10-14T03:24:56Z

Dosage

← Older revision		Revision as of 23:24, 13 October 2020
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	\|initially, up to 10-20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months.		\|initially, up to 10-20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months.
	\|-		\|-
	~~!style="text-align: left"~~\| Maintenance		\|Maintenance: usual range: 2.5 – 15 mg daily
	\|usual range: 2.5 – 15 mg daily
	\|}		\|}

Helen: /* Dosage */

2020-10-14T03:24:22Z

Dosage

← Older revision		Revision as of 23:24, 13 October 2020
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	{\| class="wikitable"		{\| class="wikitable"
	!style="text-align: left"\| Oral		!style="text-align: left"\| Oral
	\|initially, up to 10-20 mg daily (severe disease, up to 60 mg daily),		\|initially, up to 10-20 mg daily (severe disease, up to 60 mg daily), preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months.
	\|-
	~~!style="text-align: left"\|~~ preferably taken in the morning after breakfast; can often be reduced within a few days but may need to be continued for several weeks or months.
	~~\|Maintenance, usual range: 2.5 – 15 mg daily~~
	\|-		\|-
			!style="text-align: left"\| Maintenance
			\|usual range: 2.5 – 15 mg daily
			\|}

			{\| class="wikitable"
	!style="text-align: left"\| Child and infant dose		!style="text-align: left"\| Child and infant dose
	\|-		\|-
	\|Usually indicated for mild to moderate acute asthma		\|Usually indicated for mild to moderate acute asthma
	\|-		\|-
	\|1 month to 11 years old		\|1 month to 11 years old:1-2mg/kg once daily, max 40 mg daily
	\|1-2mg/kg once daily, max 40 mg daily
	\|-		\|-
	\|Child 12-17 years old		\|Child 12-17 years old:\|40-50 mg daily for at least 5 days
	\|40-50 mg daily for at least 5 days		\|}
	\|-
	!style="text-align: left"\|By intramuscular injection		{\| class="wikitable"
			!style="text-align: left"\| By intramuscular injection
	\|prednisolone acetate 25 – 100 mg once or twice		\|prednisolone acetate 25 – 100 mg once or twice
	weekly		weekly
	\|		\|-
	For intra-articular injection~~'',~~ 5 to 25 mg of prednisolone acetate.		!style="text-align: left"\| For intra-articular injection
			\|5 to 25 mg of prednisolone acetate.
			\|}

	Prednisolone acetate and prednisolone sodium phosphate are also used in the topical treatment of allergic and inflammatory conditions of the eyes or ears, usually as drops containing 0.5 or 1%.		Prednisolone acetate and prednisolone sodium phosphate are also used in the topical treatment of allergic and inflammatory conditions of the eyes or ears, usually as drops containing 0.5 or 1%.


	==Side Effects==		==Side Effects==

Helen at 03:13, 14 October 2020

2020-10-14T03:13:20Z

Show changes

Helen at 04:42, 9 October 2020

2020-10-09T04:42:05Z

← Older revision		Revision as of 00:42, 9 October 2020
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	[[Category: Drugs]][[Category: Steroids]]		[[Category: Drugs]][[Category: Steroids]]
	~~==Pronunciation==~~		'''Prednisolone''' (中文: [[潑尼松龍]]) is a steroid with anti-inflammatory and immunosuppressant effects. It is used to treat a wide range of inflammatory and autoimmune conditions.
	~~===~~Prednisolone ~~5mg===~~
	[[~~File:Prednisolone 5mg.mp3~~]]


	~~== Introduction ==~~

	~~Prednisolone~~ is a steroid with anti-inflammatory and immunosuppressant effects. It is used to treat a wide range of inflammatory and autoimmune conditions.

	Indications include:		Indications include:
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	*Dermatitis		*Dermatitis
	*Rheumatoid arthritis		*Rheumatoid arthritis
			==Pronunciation==
			===Prednisolone 5mg===
			[[File:Prednisolone 5mg.mp3]]



			==Drug Names==
	'''Equivalent anti-inflammatory doses of steroids		'''Equivalent anti-inflammatory doses of steroids
	{\| class = "wikitable"		{\| class = "wikitable"

Helen: /* Pharmacokinetics */

2020-10-05T07:11:35Z

Pharmacokinetics

← Older revision		Revision as of 03:11, 5 October 2020
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	==Pharmacokinetics==		==Pharmacokinetics==


	{\| class = "wikitable"		{\| class = "wikitable"
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	Prednisolone is largely inactivated as it crosses the placenta; small amounts are excreted in breast milk.		Prednisolone is largely inactivated as it crosses the placenta; small amounts are excreted in breast milk.


	==Drug Management==		==Drug Management==

Helen: /* Side Effects */

2020-10-05T07:11:08Z

Side Effects

Show changes

Helen: /* Dosage */

2020-10-05T07:01:43Z

Dosage

← Older revision		Revision as of 03:01, 5 October 2020
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	Child 12-17 years old: 40-50 mg daily for at least 5 days		Child 12-17 years old: 40-50 mg daily for at least 5 days

			''By intramuscular injection'', prednisolone acetate 25 – 100 mg once or twice
			weekly

			''For intra-articular injection'', 5 to 25 mg of prednisolone acetate.

			Prednisolone acetate and prednisolone sodium phosphate are also used in the topical treatment of allergic and inflammatory conditions of the eyes or ears, usually as drops containing 0.5 or 1%.


			==Side Effects==

			Short-term use include nausea and feeling tired. More severe side effects include psychiatric problems including euphoria, nightmares, insomnia, irritability, confusion, suicidal thoughts and behavioral disturbances. This may occur in about 5% of people.

			Long-term steroid use can lead to:

			{\| class = "wikitable"
			!style="text-align: left"\| Adrenal suppression
			\|
			\|-
			!\|Steroid-induced diabetes
			\|
			\|-
			!\|Osteoporosis, muscle wasting and weakness
			\|which is a danger, particularly in the elderly, as it can result in osteoporotic fractures for example of the hip or vertebrae
			\|-
			!style="text-align: left"\| Susceptibility to infection
			\|
			\|-
			!style="text-align: left"\| Cushing’s syndrome
			\|moon face, striae, and acne
			\|-
			!style="text-align: left"\| Endocrine side effects
			\|menstrual irregularities and amenorrhea, hirsutism, weight gain, hyperlipidemia
			\|-
			!Neuropsychiatric side effects
			\|aggravation of schizophrenia, aggravation of epilepsy, insomnia, irritability, mood changes
			\|-
			!Dermatological effects
			\|easy bruising, impaired wound healing, and thinning of skin
			\|-
			!Ophthalmic effects
			\|glaucoma, corneal or scleral thinning and exacerbation of ophthalmic viral or fungal disease

			\|}

			Side-effects can be minimized by using lowest effective dose for minimum period possible.