Zeki at 06:25, 21 October 2024

2024-10-21T06:25:56Z

← Older revision		Revision as of 02:25, 21 October 2024
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	'''Drug class: [[:Category: Monoamine oxidase B inhibitor \| Monoamine Oxidase B Inhibitor, MAO-B Inhibitor]]		'''Drug class: [[:Category: Monoamine oxidase B inhibitor \| Monoamine Oxidase B Inhibitor, MAO-B Inhibitor]]

	'''Rasagiline'''（中文：[[雷沙吉蘭]]）		'''Rasagiline (AZILECT)'''（中文：[[雷沙吉蘭]]）
	==Common Strengths of Rasagiline==		==Common Strengths of Rasagiline==
	Rasagiline is available in the following strength: 1 mg		Rasagiline is available in the following strength: 1 mg

Zeki at 02:13, 21 October 2024

2024-10-21T02:13:18Z

← Older revision		Revision as of 22:13, 20 October 2024
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	'''Rasagiline'''（中文：[[雷沙吉蘭]]）		'''Rasagiline'''（中文：[[雷沙吉蘭]]）
			==Common Strengths of Rasagiline==
			Rasagiline is available in the following strength: 1 mg

			==Drug Trade Names==
			Azilect

			==Drug Usage==
			Rasagiline is used to treat symptoms of Parkinson's disease, including:
			*Stiffness
			*Tremors
			*Spasms
			*Poor muscle contorl

			==Mechanism of Action==
			Rasagiline act as an irreversible inhibitor of monoamine oxidase B (MAO-B), leading to increased levels of dopamine in the brain. This mechanism helps improve dopaminergic activity, which is beneficial for managing motor dysfunction in Parkinson's disease.

			==Route of Administration==
			Oral

			==Dosage==
			*Monotherapy: 1 mg once daily.
			*Adjunct therapy with levodopa: Initial dose of 0.5 mg once daily, can be increased to 1 mg as tolerated.

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="4" \| '''Common Side Effects
			\| Insomnia
			\|-
			\| Weight loss
			\|-
			\| Nausea
			\|-
			\| Dizziness
			\|-
			\| rowspan="4" \| '''Serious Side Effects
			\| Serotonin syndrome (symptoms include agitation and hallucinations)
			\|-
			\| Severe headache or blurred vision
			\|-
			\| Exterme drowsiness or sudden sleep spisodes
			\|-
			\| Uncontrolled muscle movements or worsening Parkinson's sympotms
			\|}

			==Pharmacokinetics==
			Rasagiline has an absolute bioavailability of approximately 36%.

			The onset time for therapeutic effects typically ranges from two to three weeks, with lasting throughout the day when taken once daily.

			==Drug Precautions==
			'''Pregnancy

			Rasagiline is categorized as Pregnancy Category C, indicating that risk cannot be ruled out; it should only be used if clearly needed.

			'''Breastfeeding

			Caution is advised as it may inhibit milk secretion; the safety during breastfeeding has not been established.

			'''Drug Monitoring Items
			*Impulse contorl disorders: Some patients may experience increased urges related to gambling or sexuality.
			*Monitoring blood pressure: hypertensive crises, particularly when combined with tyramine-rich food or certain medications.
			*Assessing for signs of serotonin syndrome including agitation and hallucination, rapid heart rate and muscle twitching.

			'''Drug Interactions

			Rasagiline can interact with several medications, including:
			*Other MAO inhibitor (e.g. selegiline): Coadministration with other MAO inhibitors can lead to severe hypertensive episodes. It is advised to avoid such combinations for at least 14 days.
			*Certain antidepressant (e.g. St. John's wort) and over-the-counter products like dextromethorphan should be avoided unless under strict medical supervision
			*Opioids (e.g. meperidine)
			*Food interactions: Patients are advised to avoid high-tyramine foods (e.g. aged cheeses) to prevent hypertensive crises.

			==FAQ==
			'''How Should I Take the Tablet?

			Take rasagiline orally once daily, with or without food.

			'''What Should I Avoid While Taking?

			Avoid consuming tyramine-rich food (e.g. aged cheese) and other MAO inhibitors, as they can cause hypertensive crisis.

			'''What Happens if I Miss a Dose?

			If you miss a dose, take it as soon as you remember on the same day; do not double up on doses if it's close to your next scheduled dose.

Zeki: Created page with "Category: DrugsCategory: Monoamine oxidase B inhibitor '''Antiparkinsonian Drug''' '''Drug class: :Category: Monoamine oxida..."

2024-10-21T01:35:11Z

Created page with "Category: Drugs Category: Monoamine oxidase B inhibitor '''Antiparkinsonian Drug''' '''Drug class: :Category: Monoamine oxida..."

New page

[[Category: Drugs]][[Category: Monoamine oxidase B inhibitor]]

[[:Category: Antiparkinsonian Drug | '''Antiparkinsonian Drug''']]

'''Drug class: [[:Category: Monoamine oxidase B inhibitor | Monoamine Oxidase B Inhibitor, MAO-B Inhibitor]]

'''Rasagiline'''（中文：[[雷沙吉蘭]]）

Rasagiline - Revision history

Zeki at 06:25, 21 October 2024

Zeki at 02:13, 21 October 2024

Zeki: Created page with "Category: DrugsCategory: Monoamine oxidase B inhibitor '''Antiparkinsonian Drug''' '''Drug class: :Category: Monoamine oxida..."