Zeki at 06:26, 21 October 2024

2024-10-21T06:26:29Z

← Older revision		Revision as of 02:26, 21 October 2024
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	'''Drug class: [[:Category: Monoamine oxidase B inhibitor \| Monoamine Oxidase B Inhibitor, MAO-B Inhibitor]]		'''Drug class: [[:Category: Monoamine oxidase B inhibitor \| Monoamine Oxidase B Inhibitor, MAO-B Inhibitor]]

	'''Selegiline'''（中文：[[司來吉蘭]]）		'''Selegiline (ELDEPRYL)'''（中文：[[司來吉蘭]]）
	==Common Strengths of Selegiline==		==Common Strengths of Selegiline==
	*Oral Tablets: 5 mg		*Oral Tablets: 5 mg

Zeki: /* FAQ */

2024-10-21T03:46:28Z

FAQ

← Older revision		Revision as of 23:46, 20 October 2024
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	'''What Should I Avoid While Taking?		'''What Should I Avoid While Taking?

	Avoid tyramine-rich foods (e.g. aged cheeses and cured meats) and certain medications that can interact dangerously with selegiline, as listed in section " Drug Interactions".		Avoid tyramine-rich foods (e.g. aged cheeses and cured meats) and certain medications that can interact dangerously with selegiline, as listed in section 9 part "Drug Interactions".

	'''What Happens if I Miss a Dose?		'''What Happens if I Miss a Dose?

	Take it as soon as youy remember unless it is almost time for your next dose. Do not double doses.		Take it as soon as youy remember unless it is almost time for your next dose. Do not double doses.

Zeki at 03:46, 21 October 2024

2024-10-21T03:46:06Z

← Older revision		Revision as of 23:46, 20 October 2024
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	'''Selegiline'''（中文：[[司來吉蘭]]）		'''Selegiline'''（中文：[[司來吉蘭]]）
			==Common Strengths of Selegiline==
			*Oral Tablets: 5 mg

			==Drug Trade Names==
			*Eldepryl

			==Drug Usage==
			*Parkinson's Disease: Used to manage symptoms, often in conjunction with levodopa.
			*Major Depressive Disorder: Available as a transdermal patch (Emsam) specifically for this indication.

			==Mechanism of Action==
			Selegiline selectively inhibits monoamine oxidase type B (MAO-B), which prevents the breakdonw of dopamine in the brain, thereby increasing its levels. At higher doses, it also inhibits monoamine oxidase type A (MAO-A), affecting serotonin and norepinephrine levels.

			==Route of Administration==
			*Oral (Tablet)
			*Transdermal patch

			==Dosages==
			*Oral: 5 mg twice daily (maximum 10 mg/day).

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="4" \| '''Common Side Effects
			\| Dizziness
			\|-
			\| Nausea
			\|-
			\| Insomnia
			\|-
			\| Skin rash
			\|-
			\| rowspan="3" \| '''Serious Side Effects
			\| Hypertensive crisis
			\|-
			\| Serotonin syndrome
			\|-
			\| Uncontrollable urges (gambling, eating)
			\|}

			==Pharmacokinetics==
			*Onset of Action: Typically within hours
			*Duration: Effects can last up to 24 hours depending on the formulation.

			==Drug Precautions==
			'''Pregnancy

			Use with caution; benefits must outweigh risks.

			'''Breastfeeding

			Safety is unclear; use caution if breastfeeding.

			'''Drug Monitoring Items
			*Blood Pressure Monitoring: Patients should regularly monitor their blood pressure to manage the risk of orthostatic hypotension and prevernt hypertensive crises.
			*Parkinsonism Symptoms: Patients should be monitored for worsening Parkinsonian symptoms, which may indicate inadequate control of the disease or adverse effects from the medication.
			*Serotonin Syndrome: Symptoms such as agitation, confusion, and muscle spasms should be closely observed, especially if selegiline is combined with other serotonergic medications.
			*Behavioral Changes: Regular assessments for mood changes and suicidal thoughts are necessary.

			'''Drug Interactions

			Selegiline has significant interactions with:
			*Serotonergic Agents
			**SSRIs and SNRIs: Comgining selegiline with selective serotonin reuptake inhibitors (e.g. fluoxetine, sertraline) or serotonin-norepinephrine reuptake inhibitors (e.g. venlafaxine) can lead to serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as agitation, confusion, rapid heart rate, and muscle rigidity.
			*Opioids
			**Meperidine and Tramadol: The use of selegiline with opioids like meperidine or tramadol is contraindicated due to the risk of severe side effects, including respiratory depression and serotonin syndrome.
			*Indirect Sympathominetics
			**Amphetamines and Ephedrine: These can cause hypertensive Crises when taken with selegiline due to increased norepinephrine levels. Monitoring blood pressure is essential when these combinations are necessary.
			*Dextromethorphan
			**This common cough suppressant can also lead to serotonin syndrome when used concurrently with selegiline.
			*Antidepressants
			**tricyclic antidepressants (e.g. amitriptyline) can interact with selegiline, necessitating caution and possibly dose adjustments.
			*Benzodiazepines
			**The combination may enhance CNS depression effects, requiring careful monitoring and possible dose adjustments.
			*Food and Alcohol Interactions
			**Tyramine-Rich Foods: Patients taking selegiline should avoid foods high in tyramine (e.g. aged cheeses, and cured meats) to prevent hypertensive crises.
			**Alcohol: Using alcohol while on selegiline may exacerbate side effects such as dizziness and drowsiness.

			==FAQ==
			'''How Should I Take the Tablet?

			Take orally as prescribed.

			'''What Should I Avoid While Taking?

			Avoid tyramine-rich foods (e.g. aged cheeses and cured meats) and certain medications that can interact dangerously with selegiline, as listed in section " Drug Interactions".

			'''What Happens if I Miss a Dose?

			Take it as soon as youy remember unless it is almost time for your next dose. Do not double doses.

Zeki: Created page with "Category: DrugsCategory: Monoamine oxidase B inhibitor '''Antiparkinsonian Drug''' '''Drug class: :Category: Monoamine oxida..."

2024-10-21T03:03:30Z

Created page with "Category: Drugs Category: Monoamine oxidase B inhibitor '''Antiparkinsonian Drug''' '''Drug class: :Category: Monoamine oxida..."

New page

[[Category: Drugs]][[Category: Monoamine oxidase B inhibitor]]

[[:Category: Antiparkinsonian Drug | '''Antiparkinsonian Drug''']]

'''Drug class: [[:Category: Monoamine oxidase B inhibitor | Monoamine Oxidase B Inhibitor, MAO-B Inhibitor]]

'''Selegiline'''（中文：[[司來吉蘭]]）

Selegiline - Revision history

Zeki at 06:26, 21 October 2024

Zeki: /* FAQ */

Zeki at 03:46, 21 October 2024

Zeki: Created page with "Category: DrugsCategory: Monoamine oxidase B inhibitor '''Antiparkinsonian Drug''' '''Drug class: :Category: Monoamine oxida..."