Sertraline - Revision history

Zeki at 02:56, 8 August 2024

2024-08-08T02:56:41Z

← Older revision		Revision as of 22:56, 7 August 2024
Line 85:		Line 85:
	\| QT interval prolongation may lead to heart arrhythmias		\| QT interval prolongation may lead to heart arrhythmias
	\|}		\|}

			==Pharmacokinetics==
			*Metabolism: Hepatic via CYP2D6, CYP3A4, and others
			*Elimination: Primarily renal
			*Half-life: Approximately 26 hours
			*Onset: 4 to 6 weeks for full antidepressant effect

			==Drug Precautions==
			'''Pregnancy

			Use only if the potential benefit justifies the risk to the fetus

			'''Breastfeeding

			Present in breast milk, use with caution

			'''Children and Elderly

			Not approved for use in pediatric patients with depression. Lower doses are recommended for the elderly due to increased sensitivity to side effects

			'''Monitoring Requirements
			*Monitor for suicidal thoughts, especially in young adults
			*Monitor for serotonin syndrome, especially when combined with other serotonergic drugs
			*Regularly assess liver function and electrolyte levels

			'''Drug Interactions
			*Contraindicated with thioridazine due to risk of serotonin syndrome and QT prolongation
			*Caution with other serotonergic drugs, NSAIDs, anticoagulants, and drugs affecting CYP2D6 metabolism

			==FAQ==
			'''How Should I Take the Tablet?

			Take orally with or without food, usually once daily in the morning

			'''What Should I Avoid While Taking?

			Avoid alcohol and activities requiring mental alertness until you know how the tablet affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time form your next dose. Do not double doses.

Zeki at 02:37, 8 August 2024

2024-08-08T02:37:47Z

← Older revision		Revision as of 22:37, 7 August 2024
Line 68:		Line 68:
	\| rowspan="9" \| '''Serious		\| rowspan="9" \| '''Serious
	\| Suicidal Thoughts or Actions: Especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusua changes in mood or behavior.		\| Suicidal Thoughts or Actions: Especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusua changes in mood or behavior.
			\|-
			\| Serotonin Syndrome: This potentially life-threatening condition can occur when there is too much serotonin in the body. Symptoms include agitation, hallucinations, rapid heart rate, fever, nausea, vomiting, diarrhea, and muscle twitching.
			\|-
			\| Severe Allergic Reactions: These include symptoms like difficulty breathing, swelling of the face, lips, tongue, or throat, and severe rash or hives.
			\|-
			\| Abnormal Bleeding: Can manifest as unusual bruising or bleeding
			\|-
			\| Low Sodium Levels: Particularly in older adults, symptoms include headache, confusion, weakness, and difficulty concentrating.
			\|-
			\| Mania: Symptoms include excessively high energy, severe trouble sleeping, racing thoughts, reckless behavior, and unusually grand ideas.
			\|-
			\| Seizures
			\|-
			\| Angle-closure glaucoma (eye pain, vision changes)
			\|-
			\| QT interval prolongation may lead to heart arrhythmias
			\|}

Zeki at 02:24, 8 August 2024

2024-08-08T02:24:57Z

← Older revision		Revision as of 22:24, 7 August 2024
Line 6:		Line 6:

	'''Sertraline (ZOLOFT)'''（中文：[[舍曲林]]）		'''Sertraline (ZOLOFT)'''（中文：[[舍曲林]]）
			==Common Strengths of Sertraline==
			Sertraline are available in the following strengths:
			*Tablets: 25 mg, 50 mg, 100 mg
			*Capsules: 150 mg, 200 mg
			*Oral solution: 20 mg/mL

			==Drug Trade Names of Sertraline==
			Zoloft
			==Drug Usage==
			*Major depressive disorder
			*Obsessive-compulsive disorder (OCD)
			*Panic disorder
			*Social anxiety disorder
			*Generalized anxiety disorder
			*Post-traumatic stree disorder (PTSD)

			==Mechanism of Action==
			Sertraline is a selective serotonin reuptake inhibitor (SSRI). It works by increaasing serotonin levels in the brain by inhibiting its reuptake into presynaptic neurons, thereby enhancing serotonergic activity.

			==Route of Administration==
			Oral

			==Dosages==
			*Depression: 50 mg/day initially, may increase to 200 mg/day maximum
			*Obsessive-compulsive disorder (OCD): 50 mg/day initially, may increase to 200 mg/day maximum
			*Panic disorder: 25 mg/day initially, may increase to 200 mg/day maximum

			Renal dose based on eGFR:
			*For severe renal impairment (eGFR <30 mL/min): 25 mg/day initially, may titrate up to 200 mg/day maximum

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="12" \| '''Common
			\| Nausea: Often mitiagated by taking the medication with food
			\|-
			\| Headaches: Drinking plenty of fluids and resting can help; avoid excessive alcohol consumption
			\|-
			\| Insomnia: Taking fluoxetine in the morming may reduce sleep disurbances
			\|-
			\| Fatigue or Weakness: Resting and avoiding activities that require alertness, such as driving
			\|-
			\| Sexual Dysfunction: This includes decreased libido and difficulty achieving orgasm
			\|-
			\| Diarrhoea
			\|-
			\| Dry Mouth: Staying hydrated and using sugar-free gum or candy can help alleviate dry mouth
			\|-
			\| Dizziness: Moving slowly when changing positions can help reduce dizziness
			\|-
			\| Sweating
			\|-
			\| Anxiety
			\|-
			\| Tremor/shaking
			\|-
			\| Indigestion/heratburn
			\|-
			\| rowspan="9" \| '''Serious
			\| Suicidal Thoughts or Actions: Especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusua changes in mood or behavior.

Zeki: Created page with "Category: DrugsCategory: Selective serotonin reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Selective..."

2024-08-05T07:28:38Z

Created page with "Category: Drugs Category: Selective serotonin reuptake inhibitor '''Antidepressant Drug''' '''Drug class: :Category: Selective..."

New page

[[Category: Drugs]][[Category: Selective serotonin reuptake inhibitor]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Selective serotonin reuptake inhibitor | Selective Serotonin Reuptake Inhibitor]]

'''Sertraline (ZOLOFT)'''（中文：[[舍曲林]]）