Sitagliptin - Revision history

Zeki at 06:03, 4 July 2024

2024-07-04T06:03:59Z

← Older revision		Revision as of 02:03, 4 July 2024
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	[[:Category: Antidiabetic Drug \| '''Antidiabetic Drug''']]		[[:Category: Antidiabetic Drug \| '''Antidiabetic Drug''']]

	'''Drug class: [[:Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor \| Dipeptidyl peptidase-4 (DPP-4) inhibitor]]~~'''~~		'''Drug class: [[:Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor \| Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

	'''Sitagliptin (JANUVIA)'''（中文：[[西格列汀]]）		'''Sitagliptin (JANUVIA)'''（中文：[[西格列汀]]）

Zeki at 05:58, 4 July 2024

2024-07-04T05:58:48Z

← Older revision		Revision as of 01:58, 4 July 2024
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	===Sitagliptin 100mg (JANUVIA 100mg)===		===Sitagliptin 100mg (JANUVIA 100mg)===
	[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]		[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]

			==Common Strengths of Sitagliptin Tablet==
			Sitagliptin tablets are available in the following strengths:
			*25 mg, 50 mg, 100 mg tablets

			==Drug Trade Names of Sitagliptin Tablet==
			Januvia is the trade name for Sitagliptin

			It is also sold under various brand names when combined with other antidiabetic medications, such as:
			*JANUMET TABLET 50MG/1000MG: Sitagliptin 50mg + Metformin 1000mg
			*JANUMET TABLET 50MG/500MG: Sitagliptin 50mg + Metformin 500mg
			*JANUMET XR TABLET 100MG/1000MG : Sitagliptin 100mg + Metformin 1000mg
			*JANUMET XR TABLET 50MG/1000MG: Sitagliptin 50mg + Metformin 1000mg
			*JANUMET XR TABLET 50MG/500MG: Sitagliptin 50mg + Metformin 500mg
			*STEGLUJAN TABLET 5MG/100MG: Ertugliflozin 5mg + Sitagliptin 100mg

			==Drug Usage==
			Treatment of type 2 diabetes mellitus.

			==Mechanism of Action==
			Inhibits DPP-4 enzyme, increasing levels of incretin hormones (GLP-1 and GIP) which stimulate insulin release and decrease glucagon secretion, thereby lowering blood glucose.

			==Route of Administration==
			Oral

			==Dosages==
			*100 mg once daily
			*Hypertension/Heart failure: No specific dosage adjustments
			*Diabetic kidney disease:
			**eGFR 45 - 90 mL/min/1.73 m<sup>2</sup>: No adjustment
			**eGFR 30 - 45 mL/min/1.73 m<sup>2</sup>: 50 mg once daily
			**eGFR <30 mL/min/1.73 m<sup>2</sup>: 25 mg once daily

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| '''Common
			\| Upper respiratory tract infection, headache
			\|-
			\| rowspan="4" \| '''Uncommon
			\| Dizziness, nausea, vomiting
			\|-
			\| Pancreatitis
			\|-
			\| Bullous pemphigoid
			\|-
			\| Severe cutaneous adverse reactions
			\|}

			==Pharmacokinetics==
			*Absorption
			**Rapid, 87% bioavailability. The drug reaches maximum plasma concentration in 1 to 4 hours after taking a dose.
			*Metabolism
			**Limited metabolism, primarily by CYP3A4 and CYP2C8
			*Elimination
			**79% excreted unchanged in urine, half-life approximately 12 hours

			==Drug Precautions==
			'''Pregnancy

			Limited data, use only if clearly needed

			'''Breastfeeding

			Not recommended

			'''Children and Elderly

			Not approved for children, use with caution in elderly

			'''Renal Impairment

			Dose adjustment required (see dosages)

			'''Monitoring Requirements
			*Renal function
			*Blood glucose
			*HbA1c
			*Signs of pancreatitis
			The main symptoms of pancreatitis include:
			*Severe abdominal pain, typically in the upper abdomen, that may:
			**Feel worse after eating
			**Be sudden and intense in acute cases
			*Nausea and vomiting
			*Fever
			*Rapid pulse/heart rate

			'''Drug Interactions

			May enhance hypoglycemic effects of insulin or sulfonylureas

			==FAQ==
			'''How Should I Take the Tablet?

			Once daily, with or without food

			'''What Should I Avoid While Taking?

			Alcohol, skipping meals

			'''What Happens if I Miss a Dose?

			Take as soon as remembered, unless close to next dose. Do not double dose.

Zeki at 05:36, 4 July 2024

2024-07-04T05:36:28Z

← Older revision		Revision as of 01:36, 4 July 2024
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	[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]		[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

			[[:Category: Antidiabetic Drug \| '''Antidiabetic Drug''']]

			'''Drug class: [[:Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor \| Dipeptidyl peptidase-4 (DPP-4) inhibitor]]'''

			'''Sitagliptin (JANUVIA)'''（中文：[[西格列汀]]）
	==Pronunciation==		==Pronunciation==
	===Sitagliptin 100mg (JANUVIA 100mg)===		===Sitagliptin 100mg (JANUVIA 100mg)===
	[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]		[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]

Zeki at 06:05, 24 June 2024

2024-06-24T06:05:22Z

← Older revision		Revision as of 02:05, 24 June 2024
Line 1:		Line 1:
	[[Category: Drugs]]		[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

	==Pronunciation==		==Pronunciation==
	===Sitagliptin 100mg (JANUVIA 100mg)===		===Sitagliptin 100mg (JANUVIA 100mg)===
	[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]		[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]

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2020-09-08T10:00:29Z

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[[Category: Drugs]]
==Pronunciation==
===Sitagliptin 100mg (JANUVIA 100mg)===
[[File:Sitagliptin 100mg (JANUVIA 100mg).mp3]]