Sulpiride - Revision history

Zeki at 03:22, 1 August 2024

2024-08-01T03:22:21Z

← Older revision		Revision as of 23:22, 31 July 2024
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	'''Sulpiride (DOGMATIL)'''（中文：[[舒必利]]）		'''Sulpiride (DOGMATIL)'''（中文：[[舒必利]]）
			==Common Strengths of Sulpiride Tablet==
			Sulpiride are available in the following strengths:
			*50 mg, 200 mg, 400 mg tablets/capsules

			==Drug Trade Names of Sulpiride Tablet==
			Dogmatil

			==Drug Usage==
			Treatment of acute and chronic schizophrenia

			==Mechanism of Action==
			Selective dopamine D<sub>2</sub> and D<sub>3</sub> receptor antagonist

			==Route of Administration==
			Oral

			==Dosages==
			*Adults: 400 - 1200 mg daily, divided into 2 doses

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="13" \| '''Common
			\| Dizziness
			\|-
			\| Headache
			\|-
			\| Extrapyramidal side effects such as tremor, dystonia, akathisia, and parkinsonism
			\|-
			\| Drowsiness
			\|-
			\| Insomnia
			\|-
			\| Weight gain or loss
			\|-
			\| Elevated levels of prolactin which can lead to sexual dysfunction, galactorrhea, amenorrhea, and gynecomastia
			\|-
			\| Nausea
			\|-
			\| Vomiting
			\|-
			\| Nasal congestion
			\|-
			\| Anticholinergic effects such as dry mouth, constipation, and blurred vision
			\|-
			\| Impaired concentration
			\|-
			\| Increased skin sensitivity to sunlight
			\|-
			\| rowspan="8" \| '''Serious
			\| Tardive dyskinesia: A potentially irreversible condition characterized by repetitive, involuntary movements of the face and tongue
			\|-
			\| Neuroleptic Malignant Syndrome (NMS): A rare but life-threatening condition marked by muscle stiffness, high fever, confusion, fast heartbeat, and sweating
			\|-
			\| Arrhythmias, low blood pressure, and in rare cases, cardiac arrest
			\|-
			\| Severe allergic reactions: Anaphylactic shock, rash, and labored breathing
			\|-
			\| Oculogyric crisis: Spastic movements that fix the eyes in an upward position
			\|-
			\| Venous thromboembolism
			\|-
			\| Increased liver enzymes: Indicating potential liver dysfunction
			\|-
			\| Aspiration pneumonia
			\|}

			==Pharmacokinetics==
			*Time to peak plasma concentration: between 3 to 6 hours after dosing
			*Sulpiride undergoes minimal metabolism in the body. About 95% excreted unchanged in urine.

			==Drug Precautions==
			'''Pregnancy

			Use only if benefits outweigh risks. Risk of extrapyramidal/withdrawal symptoms in newborns exposed in 3rd trimester.

			'''Breastfeeding

			Excreted in breast milk.

			'''Children and Elderly
			*Children: Not recommended for children under 14 years
			*Elderly: Lower starting doses recommended

			'''Renal Impairment

			Use with caution, dose adjustment may be needed

			'''Monitoring Requirements
			*Extrapyramidal symptoms
			*Monitor for increased sedation when sulpiride is used with other CNS depressants
			*Regular ECG in patients at risk of QT prolongation
			*Monitor potassium levels when sulpiride is used with diuretics or stimulant laxatives.
			*Complete blood count
			*Liver function tests
			*Blood pressure
			*Eye examinations (long-term use)

			'''Drug Interactions
			*Increased sedation with CNS depressants:
			**Sedatives and Sleeping Pills: Drugs like nitrazepam, diazepam, and temazepam can increase the sedative effects of sulpiride, leading to enhanced drowsiness and sedation
			**Narcotics and Strong Pain Relievers: Medications such as codeine phosphate, morphine, and dihydrocodeine can also amplify CNS depression when taken with sulpiride
			*Increased risk of arrhythmias with drugs that prolong QT interval
			**Antiarrhythmics: Drugs such as disopyramide, amiodarone, sotalol, and quinidine can increase the risk of cardiac arrhythmias when used with sulpiride
			**Antihypertensives and Heart Medications: Clonidine, verapamil, diltiazem, and digitalis may have enhanced effects, potentially leading to hypotension and other cardiovascular issues
			**Diuretics and Laxatives: These can lower potassium levels, increasing the risk of cardiac arrhythmias when taken with sulpiride
			*Levodopa and Ropinirole: These drugs can antagonize the effects of sulpiride, and their combination should be avoided
			*Lithium (increased extrapyramidal effects risk)
			*Sucralfate and Magnesium Hydroxide (antacid) can decrease the absorption of sulpiride, reducing its effectiveness. It is recommended to administer sulpiride two hours before these medications

			==FAQ==
			'''How Should I Take the Tablet?

			It can be taken with or without food.

			'''What Should I Avoid While Taking?

			Avoid alcohol and activities requiring mental alertness until you know how trifluoperazine affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not double doses.

Zeki: Replaced content with "Category: DrugsCategory: Typical Antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Typical Antipsychotic |..."

2024-08-01T03:06:19Z

Replaced content with "Category: Drugs Category: Typical Antipsychotic '''Antipsychotic Drug''' '''Drug class: :Category: Typical Antipsychotic |..."

Show changes

Helen at 04:25, 3 November 2020

2020-11-03T04:25:08Z

← Older revision		Revision as of 00:25, 3 November 2020
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	[[Category: Drugs]][[Category: Antipsychotics, typical ; Antipsychotics, 1st Generation ]]		[[Category: Drugs]][[Category: Antipsychotics, typical ; Antipsychotics, 1st Generation ]]
	'''Sulpiride''' (中文:[[ ]]) is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.		'''Sulpiride''' (中文:[[舒必利]]) is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.

	==Pronunciation==		==Pronunciation==

Helen at 04:55, 27 October 2020

2020-10-27T04:55:38Z

← Older revision		Revision as of 00:55, 27 October 2020
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	[[Category: Drugs]][[Category~~: typical antipsychotic ]]~~		[[Category: Drugs]][[Category: Antipsychotics, typical ; Antipsychotics, 1st Generation ]]
	~~Drug Class~~: Antipsychotics, typical ; Antipsychotics, 1st Generation

	'''Sulpiride''' (中文:[[ ]]) is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.		'''Sulpiride''' (中文:[[ ]]) is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.

Helen: /* Drug interaction */

2020-10-27T04:32:56Z

Drug interaction

← Older revision		Revision as of 00:32, 27 October 2020
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	!style="text-align: left"\| Potential Effect		!style="text-align: left"\| Potential Effect
	\|-		\|-
	\|		\|style="text-align: left"\|
	*CNS-depressant drugs including alcohol,		*CNS-depressant drugs including alcohol,
	hypnotics, anxiolytics, sedative H1 antihistamines,		hypnotics, anxiolytics, sedative H1 antihistamines,
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	\|Increased risk of extrapyramidal effects.		\|Increased risk of extrapyramidal effects.
	\|-		\|-
	\|		\| style="text-align: left"\|
	*Tricyclic antidepressants such as amitriptyline, a CYP2D6 substrate, and pericyazine is potent inhibitor of CYP2D6.		*Tricyclic antidepressants such as amitriptyline, a CYP2D6 substrate, and pericyazine is potent inhibitor of CYP2D6.
	\|Metabolism and elimination of tricyclics significantly decreased, increased toxicity such as anticholinergic and cardiovascular side effects.		\|Metabolism and elimination of tricyclics significantly decreased, increased toxicity such as anticholinergic and cardiovascular side effects.

Helen at 04:32, 27 October 2020

2020-10-27T04:32:31Z

← Older revision		Revision as of 00:32, 27 October 2020
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	Drug Class: Antipsychotics, typical ; Antipsychotics, 1st Generation		Drug Class: Antipsychotics, typical ; Antipsychotics, 1st Generation

	'''Sulpiride''' (中文:[[ ]])is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.		'''Sulpiride''' (中文:[[ ]]) is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.

	==Pronunciation==		==Pronunciation==
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	\|Uncommon: orthostatic hypotension		\|Uncommon: orthostatic hypotension
	\|-		\|-
	!Gastrointestinal disorder		!style="text-align: left"\| Gastrointestinal disorder
	\|		\|
	Common: constipation		Common: constipation
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	\|Metabolism and elimination of tricyclics significantly decreased, increased toxicity such as anticholinergic and cardiovascular side effects.		\|Metabolism and elimination of tricyclics significantly decreased, increased toxicity such as anticholinergic and cardiovascular side effects.
	\|-		\|-
	\|		\| style="text-align: left"\|
	*Levodopa,		*Levodopa,
	*Antiparkinsonian drugs (including ropinirole)		*Antiparkinsonian drugs (including ropinirole)
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	Antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic.		Antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic.
	\|-		\|-
	\|		\| style="text-align: left"\|
	*Drugs that prolong the QT interval e.g. amiodarone, sotalol, quinidine		*Drugs that prolong the QT interval e.g. amiodarone, sotalol, quinidine
	*Drugs which induce bradycardia e.g. diltiazem, verapamil		*Drugs which induce bradycardia e.g. diltiazem, verapamil

Helen at 03:54, 27 October 2020

2020-10-27T03:54:04Z

← Older revision		Revision as of 23:54, 26 October 2020
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	[[Category: Drugs]][[Category: typical antipsychotic ]]		[[Category: Drugs]][[Category: typical antipsychotic ]]
	Drug Class: Antipsychotics, typical ; Antipsychotics, 1st Generation		Drug Class: Antipsychotics, typical ; Antipsychotics, 1st Generation

	'''Sulpiride''' (中文:[[ ]])is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.		'''Sulpiride''' (中文:[[ ]])is a typical antipsychotic or 1st Generation antipsychotic medication. It is used in the treatment of psychosis associated with schizophrenia and major depressive disorder. In low dosage, it is used for anxiety and mild depression.

Helen: /* What should I avoid while taking? */

2020-10-27T03:43:25Z

What should I avoid while taking?

← Older revision		Revision as of 23:43, 26 October 2020
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	===What should I avoid while taking?===		===What should I avoid while taking?===
	Avoid drinking alcohol while taking sulpiride because it may enhance the side effects of sedation.		Avoid drinking alcohol while taking sulpiride because it may enhance the side effects of sedation.

	Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.		Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

	===What happen if I overdose?===		===What happen if I overdose?===
	Contact your primary care doctor.		Contact your primary care doctor.

Helen: /* Drug Management */

2020-10-27T03:43:11Z

Drug Management

← Older revision		Revision as of 23:43, 26 October 2020
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	*An increased risk of ventricular arrhythmias – avoid concomitant use.		*An increased risk of ventricular arrhythmias – avoid concomitant use.
	\|}		\|}

			===Caution===
			*Sulpiride may increase prolactin levels. Therefore, caution should be exercised in patients with a history or a family history of breast cancer.
			*In patients with impaired liver
			*In patients with cardiovascular disorders, bradycardia, hypokalaemia or prolongation of QT, because of a risk of worsening of long QT-syndrome, which may also elevate the risk of tachycardia and sudden death.
			*Concomitant use with QT prolonging drugs should be avoided
			*In epileptics due to a possible lowering of the seizure threshold. The occurrence of convulsive seizures necessitates the discontinuation of treatment.
			*In patients with a history of glaucoma, urine retention or hyperplasia of the prostate.

			===Contra-indications===
			Use of sulpiride should be avoided in individuals with:
			*CNS depression
			*Comatose states
			*Parkinson’s disease
			*Phaeochromocytoma
			*Concomitant prolactin-dependent tumours e.g. pituitary gland prolactinomas and breast cancer

			===Hepatic impairment===
			*Can precipitate coma.

			===Renal impairment===
			*Start with small doses in severe renal impairment because of increased cerebral sensitivity.

			===Pregnancy===
			*Should be avoided in pregnancy.

			===Breast-feeding===
			*Use during breast feeding is not recommended.

			===Driving and skilled tasks===
			Drivers and machine operators should be told about the risk of drowsiness with this medication especially at the start of treatment. Affected patients should not drive or operate machinery.

			==FAQ==
			===How should I take the tablet?===
			You will be prescribed the lowest dose needed to control your symptoms. Take with food. Food reduces irritation.
			===What should I avoid while taking?===
			Avoid drinking alcohol while taking sulpiride because it may enhance the side effects of sedation.
			Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
			===What happen if I overdose?===
			Contact your primary care doctor.
			If emergency situation, call 999
			===What happen if I miss a dose?===
			Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the
			regular time. Do not double the dose to catch up.

Helen at 03:40, 27 October 2020

2020-10-27T03:40:08Z

← Older revision		Revision as of 23:40, 26 October 2020
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	===Drug interaction===		===Drug interaction===
	Sulpiride does not inhibits or stimulates cytochrome P450 enzymes, so would not cause clinically significant interactions with other drugs which are metabolized by CYPs.		Sulpiride does not inhibits or stimulates cytochrome P450 enzymes, so would not cause clinically significant interactions with other drugs which are metabolized by CYPs.

			{\| class="wikitable"
			!style="text-align: left"\| Drugs given with sulpiride
			!style="text-align: left"\| Potential Effect
			\|-
			\|
			*CNS-depressant drugs including alcohol,
			hypnotics, anxiolytics, sedative H1 antihistamines,
			central antihypertensives, baclofen, thalidomide and opioids.
			\|
			Potentiates the sedative effect.
			\|-
			\|style="text-align: left"\|
			*Lithium
			\|Increased risk of extrapyramidal effects.
			\|-
			\|
			*Tricyclic antidepressants such as amitriptyline, a CYP2D6 substrate, and pericyazine is potent inhibitor of CYP2D6.
			\|Metabolism and elimination of tricyclics significantly decreased, increased toxicity such as anticholinergic and cardiovascular side effects.
			\|-
			\|
			*Levodopa,
			*Antiparkinsonian drugs (including ropinirole)
			\|
			Antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic.
			\|-
			\|
			*Drugs that prolong the QT interval e.g. amiodarone, sotalol, quinidine
			*Drugs which induce bradycardia e.g. diltiazem, verapamil
			*Drugs which can cause hypokalaemia such as diuretics e.g. frusemide
			\|
			*An increased risk of ventricular arrhythmias – avoid concomitant use.
			\|}