Topiramate - Revision history

Zeki at 05:32, 5 September 2024

2024-09-05T05:32:38Z

← Older revision		Revision as of 01:32, 5 September 2024
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	[[Category: Drugs]] [[Category: Seizures]]		[[Category: Drugs]][[Category: Anticonvulsant]] [[Category:Seizures]]

			[[:Category: Anticonvulsant \| '''Anticonvulsant''']]

	'''Topiramate'''(中文: [[托吡酯]]) is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.		'''Topiramate'''(中文: [[托吡酯]]) is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.

Helen: /* Breast-feeding */

2020-10-12T08:29:18Z

Breast-feeding

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	Use during breast feeding is not recommended.		Use during breast feeding is not recommended.

	~~'''~~Epilepsy and driving		===Epilepsy and driving===

	Driving by patients with epilepsy is generally regulated. Also, antiepileptic drugs may produce CNS-related adverse effects, including dizziness and drowsiness, that could impair a patient’s ability to drive a vehicle or operate machinery, particularly during the initial stages of therapy.		Driving by patients with epilepsy is generally regulated. Also, antiepileptic drugs may produce CNS-related adverse effects, including dizziness and drowsiness, that could impair a patient’s ability to drive a vehicle or operate machinery, particularly during the initial stages of therapy.

Helen: /* How long does topiramate stay in your system? */

2020-10-12T08:28:20Z

How long does topiramate stay in your system?

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	===How long does topiramate stay in your system?===		===How long does topiramate stay in your system?===
			The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half.

	~~The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half.~~
	It takes approximately 5.5 x elimination half-life for a medicine to be out of your system.		It takes approximately 5.5 x elimination half-life for a medicine to be out of your system.

	It can take about 120 hours (5 days) for Topiramate to be out of one’s system.		It can take about 120 hours (5 days) for Topiramate to be out of one’s system.

Helen: /* How long does topiramate stay in your system? */

2020-10-12T08:28:02Z

How long does topiramate stay in your system?

← Older revision		Revision as of 04:28, 12 October 2020
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	The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half.		The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half.

	It takes approximately 5.5 x elimination half-life for a medicine to be out of your system.		It takes approximately 5.5 x elimination half-life for a medicine to be out of your system.

	It can take about 120 hours (5 days) for Topiramate to be out of one’s system.		It can take about 120 hours (5 days) for Topiramate to be out of one’s system.

Helen: /* Pharmacokinetics */

2020-10-12T08:27:41Z

Pharmacokinetics

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	{\|class="wikitable"		{\|class="wikitable"
	!Oral bioavailability		!style="text-align: left"\| Oral bioavailability
	\|Topiramate is rapidly absorbed after oral doses.		\|Topiramate is rapidly absorbed after oral doses.
	\|-		\|-
	!Onset of action		!style="text-align: left"\| Onset of action
	\|Peak plasma concentrations occur about 2 hours after oral doses.		\|Peak plasma concentrations occur about 2 hours after oral doses.
	\|-		\|-
	!Metabolism		!style="text-align: left"\| Metabolism
	\|It is not extensively metabolized in the liver		\|It is not extensively metabolized in the liver
	\|-		\|-
	!Elimination half-life		!style="text-align: left"\| Elimination half-life
	\|It is excreted chiefly in urine.		\|It is excreted chiefly in urine.
	The mean elimination half-life is about 21 hours.		The mean elimination half-life is about 21 hours.

Helen: /* Side Effects */

2020-10-12T08:27:11Z

Side Effects

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	{\| class="wikitable"		{\| class="wikitable"
			!style="text-align: left"\| Very Common (>10% incidence)
	\|~~'''~~Very Common~~'''~~ (>10% incidence)
	\|		\|
	*Dizziness,		*Dizziness,
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	*Paraesthesia – e.g. pins and needles		*Paraesthesia – e.g. pins and needles
	\|-		\|-
	\|~~'''~~Common~~'''~~ (1-10% incidence)		!style="text-align: left"\| Common (1-10% incidence)
	\|		\|
	*alopecia		*alopecia
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	*Suicidal ideation		*Suicidal ideation
	\|-		\|-
	\|~~'''~~Rare~~'''~~ (<0.1% of incidence)		!style="text-align: left"\| Rare (<0.1% of incidence)
	\|		\|
	*Hepatic failure, hepatitis		*Hepatic failure, hepatitis
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	Topiramate has been associated with acute myopia with secondary angle-closure glaucoma, typically occurring within 1 month of starting treatment. STOP topiramate may halt the progression of the ocular damage and may reverse the visual impairment.		Topiramate has been associated with acute myopia with secondary angle-closure glaucoma, typically occurring within 1 month of starting treatment. STOP topiramate may halt the progression of the ocular damage and may reverse the visual impairment.

	~~'''~~Overdose~~'''~~		===Overdose===

	Topiramate has been deemed the primary substance that led to fatal overdoses in cases due to polydrug exposure. Therapeutic plasma levels are usually less than 10 mg/L, but can range from 10- 150 mg/L in overdose patients. Symptoms of overdose include:		Topiramate has been deemed the primary substance that led to fatal overdoses in cases due to polydrug exposure. Therapeutic plasma levels are usually less than 10 mg/L, but can range from 10- 150 mg/L in overdose patients. Symptoms of overdose include:

Helen: /* Pharmacokinetics */

2020-10-12T08:24:07Z

Pharmacokinetics

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	\|}		\|}

	~~'''~~How long does topiramate stay in your system?~~'''~~		===How long does topiramate stay in your system?===

	The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half.		The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half.

Helen: /* Side Effects */

2020-10-12T08:23:39Z

Side Effects

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	No antidote is available. Treatment is entirely supportive		No antidote is available. Treatment is entirely supportive

	~~'''~~How long does it take for topiramate to work?~~'''~~		===How long does it take for topiramate to work?===

	For EPILEPSY, it can take 1 to 2 weeks.		For EPILEPSY, it can take 1 to 2 weeks.
	For MIGRAINES, it can take 1 month for migraine attacks to be less frequent. But it can take 2 to 3 months for topiramate to fully work.		For MIGRAINES, it can take 1 month for migraine attacks to be less frequent. But it can take 2 to 3 months for topiramate to fully work.

	~~'''~~Should I take topiramate at night or in the morning?~~'''~~		===Should I take topiramate at night or in the morning?===

	Topiramate causes drowsiness and fatigue in up to 15% of people taking it. At the start of treatment topiramate may be taken once a day, preferably at night.		Topiramate causes drowsiness and fatigue in up to 15% of people taking it. At the start of treatment topiramate may be taken once a day, preferably at night.

Helen at 02:43, 9 October 2020

2020-10-09T02:43:56Z

← Older revision		Revision as of 22:43, 8 October 2020
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	[[Category: Drugs]] [[Category: ~~Anticonvulsant medication~~]]		[[Category: Drugs]] [[Category: Seizures]]

	'''Topiramate'''(中文: [[托吡酯]]) is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.		'''Topiramate'''(中文: [[托吡酯]]) is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.

Helen at 02:17, 9 October 2020

2020-10-09T02:17:32Z

← Older revision		Revision as of 22:17, 8 October 2020
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	[[Category: Drugs]] [[Category: Anticonvulsant medication]]		[[Category: Drugs]] [[Category: Anticonvulsant medication]]

	'''Topiramate'''(中文: [[]]) is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.		'''Topiramate'''(中文: [[托吡酯]]) is a medication used to treat epilepsy and prevent migraines. For epilepsy this includes treatment for generalized or focal seizures. It is also used as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome.

	==藥名==		==Drug Names==
	{\| class="wikitable"		{\| class="wikitable"
	!Generic Name 藥名		!Generic Name 藥名