Zeki at 01:43, 15 August 2024

2024-08-15T01:43:19Z

← Older revision		Revision as of 21:43, 14 August 2024
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	Trazodone can be used in patients with renal impairment without specific adjustments, careful monitoring and cautious titration are advised to ensure safety and efficacy.		Trazodone can be used in patients with renal impairment without specific adjustments, careful monitoring and cautious titration are advised to ensure safety and efficacy.

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="9" \| '''Common
			\| Drowsiness or Fatigue: Especially when starting the medication. This effect may lesson over time.
			\|-
			\| Dry Mouth: This can often be managed with sugar-free gum or candies.
			\|-
			\| Nausea: This can sometimes be alleviated by taking trazodone with food.
			\|-
			\| Headaches: Staying hydrated may help mitigate this side effect.
			\|-
			\| Constipation: Increasing dietary fiber and fluid intake is recommended.
			\|-
			\| Dizziness: Particularly when standing up quickly, which is related to orthostatic hypotension (a drop in blood pressure upon standing).
			\|-
			\| Blurred Vision
			\|-
			\| Weight Change: This can lead to either weight gain or loss, depending on the individual.
			\|-
			\| Sexual Dysfunction: This may include problems with ejaculation or changes in libido.
			\|-
			\| rowspan="7" \| '''Serious
			\| '''Require immediate medical attention'''
			\|-
			\| Priapism: A prolonged and painful erection that can cause permanent damage if not treated promptly.
			\|-
			\| Serotonin Syndrome: A potentially life-threatening condition characterized by symptoms such as confusion, rapid hearbeat, and muscle rigidity, especially if taken with other serotonergic drugs.
			\|-
			\| Allergic Reactions: Symptoms may include swelling of the face, lips, or throat, difficulty breathing, and hives.
			\|-
			\| Suicidal Thoughts: Increased risk of suicidal ideation, particularly in young adults and adolescents, especially during the initial treatment phase or when doses are changed.
			\|-
			\| Trazodone can cause QT prolongation, which may lead to serious heart arrhythmia.
			\|-
			\| Unexplained Bruising or Bleeding-Confusion, tremor, skin reactions.
			\|}

			==Pharmacokinetics==
			*Peak plasma concentration is typically reached within 1 to 2 hours when taken on an empty stomach. However, food can affect its absorption and a delay in the time to peak concentration.
			*Extensive metabolism in the liver by the enzyme CYP3A4.
			*The elimination half-life of trazodone varies between 5 to 9 hours. The half-life can be prolonged in elderly individuals.
			*Excretion: Approximately 70% to 75% of trazodone is excreted in urine and about 21% is eliminated via feces.

			Onset of Action:
			*For Insomnia: Trazodone can start to exert its sedative effects within '''30 minutes''' to '''2 hours''' after oral administration.
			*For Depression and Anxiety: The onset for these conditions is slower, typically taking 1 to 2 weeks to begin noticing effects, with full therapeutic benefits often taking 4 to 6 weeks to manifest.

			==Drug Precautions==
			'''Pregnancy

			Use with caution; potential risks to the fetus

			'''Breastfeeding

			Use with caution; trazodone is excreted in breast milk

			'''Children and Elderly
			*Not recommended for children under 18 for depression
			*Elderly may require lower doses due to decreased clearance

			'''Monitoring Requirements
			*Signs of suicidal thoughts or behaviors
			*Blood pressure
			*Liver function
			*Signs of serotonin syndrome

			'''Drug Inetractions
			*Serotonergic Drugs: Combining trazodone with other medications that increase serotonin levels can lead to serotonin syndrome, a potentially life-threatening condition. This includes:
			**Buspirone
			**Fentanyl
			**Lithium
			**St.John's Wort
			**Triptans (e.e. simatriptan, zolmitriptan)

			*CNS Depressants: Trazodone can enhance the sedative effects of other central nervous system depressants, such as:
			**Benzodiazepines (e.g. lorazepam, alprazolam)
			**Alcohol
			**Opioids (e.g. hydrocodone, oxycodone)

			*Antidepressants: Caution is advised when combining trazodone with other antidepressants, especially SSRIs and SNRIs, as this can increase the risk of serotonin syndrome.

			*Anticoagulants and Antiplatelet Drugs: Trazodone may increase the risk of bleeding when taken with:
			**Warfarin
			**NSAIDs
			**Aspirin

			*CYP4A4 Inhibitors and Inducers: Trazodone is metabolized by the CYP3A4 enzyme, so drugs that inhibit or induce this enzyme can ater trazodone levels. For example:
			**Inhibitors (e.g. ketoconazole) may increase trazodone levels, necessitating a dose reduction
			**Inducers (e.g. rifampin) may decrease trazodone levels, potentially requiring an increase in dosage.

			==FAQ==
			'''How Should I Take the Tablet?

			Take the tablets shortly after a meal or light snack. Tablets can be swallowed whole or broken in half along the score line. Do not crush or chew.

			'''What Should I Avoid While Taking?

			Avoid alcohol and operating heavy machinery until you know how trazodone affects you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember unless it is almost time for your next dose. Do not doule doses.

Zeki at 08:11, 12 August 2024

2024-08-12T08:11:13Z

← Older revision		Revision as of 04:11, 12 August 2024
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	Trazodone are available in the following strengths:		Trazodone are available in the following strengths:
	*50 mg, 75 mg, 100 mg, 150 mg		*50 mg, 75 mg, 100 mg, 150 mg

			==Drug Trade Names of Trazodone==
			*Trittico
			*Desyrel

			==Drug Usage==
			*Major depressive disorder (MDD)
			*Off-label uses: Anxiety, insomnia, alcohol dependence

			==Mechanism of Action==
			Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). It works by:
			*Antagonizing 5-HT<sub>2A</sub> receptors
			*Inhibiting serotonin reuptake
			*Blocking histamine H1 and α1-adrenergic receptors

			==Route of Administration==
			Oral

			==Dosages==
			*Major depressive disorder (MDD):
			**Initial: 150 mg/day in divided doses
			**Maintenance: 150-400 mg/day
			**Maximum: 400 mg/day (outpatients), 600 mg/day (inpatients)

			Trazodone can be used in patients with renal impairment without specific adjustments, careful monitoring and cautious titration are advised to ensure safety and efficacy.

Zeki at 07:33, 12 August 2024

2024-08-12T07:33:02Z

@@ Line 1: / Line 1: @@
 [[Category: Drugs]][[Category: Atypical antidepressants]]
 ==Pronunciation==
 ===Trazodone 50mg===
 [[File:Trazodone 50mg.mp3]]

Zeki at 07:21, 12 August 2024

2024-08-12T07:21:48Z

← Older revision		Revision as of 03:21, 12 August 2024
Line 1:		Line 1:
	[[Category: Drugs]]		[[Category: Drugs]][[Category: Atypical antidepressants]]
	==Pronunciation==		==Pronunciation==
	===Trazodone 50mg===		===Trazodone 50mg===
	[[File:Trazodone 50mg.mp3]]		[[File:Trazodone 50mg.mp3]]

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2020-09-08T10:03:29Z

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[[Category: Drugs]]
==Pronunciation==
===Trazodone 50mg===
[[File:Trazodone 50mg.mp3]]

Trazodone - Revision history

Zeki at 01:43, 15 August 2024

Zeki at 08:11, 12 August 2024

Zeki at 07:33, 12 August 2024

Zeki at 07:21, 12 August 2024

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