Zeki at 05:51, 26 August 2024

2024-08-26T05:51:44Z

← Older revision		Revision as of 01:51, 26 August 2024
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	[[Category: Drugs]][[Category: Benzodiazepine]]		[[Category: Drugs]][[Category: Benzodiazepine]]

	[[:Category: ~~Antidepressant Drug~~ \| '''~~Antidepressant Drug~~''']]		[[:Category: Anxiolytic and Hypnotic Drugs \| '''Anxiolytic and Hypnotic Drugs''']]

	'''Drug class: [[:Category: Benzodiazepine \| Benzodiazepine, BDZs]]		'''Drug class: [[:Category: Benzodiazepine \| Benzodiazepine, BDZs]]

Zeki: Created page with "Category: DrugsCategory: Benzodiazepine '''Antidepressant Drug''' '''Drug class: :Category: Benzodiazepine | Benzodiazepine, B..."

2024-08-26T05:46:50Z

Created page with "Category: Drugs Category: Benzodiazepine '''Antidepressant Drug''' '''Drug class: :Category: Benzodiazepine | Benzodiazepine, B..."

New page

[[Category: Drugs]][[Category: Benzodiazepine]]

[[:Category: Antidepressant Drug | '''Antidepressant Drug''']]

'''Drug class: [[:Category: Benzodiazepine | Benzodiazepine, BDZs]]

'''Triazolam (HALCION)'''（中文：[[三唑侖]]）
==Common Strengths of Triazolam==
Triazolam are available in the following strengths:
*Tablets: 0.125 mg, 0.25 mg

==Drug Trade Names of Triazolam==
Halcion

==Drug Usage==
*Short-term treatment of insomnia (generally 7 to 10 days)
*Anxiety disorders

==Mechanism of Action==
Triazolam works by binding to the benzodiazepine site on the GABA<sub>A</sub> receptor, enhancing GABA's inhibitory effects, leading to sedation, anxiolysis, and muscle relaxtion.

==Route of Administration==
Oral

==Dosages==
For Insomnia:
*Initial Dose: 0.25 mg orally once a day at bedtime.
*Maintenance Dose: 0.125 to 0.25 mg orally once a day at bedtime.
*Maximum Dose: 0.5 mg/day.

Elderly or Debilitated Patients:
*Initial Dose: 0.125 mg orally once a day at bedtime.
*Maintenance Dose: 0.125 to 0.25 mg orally once a day at bedtime.
*Maximum Dose: 0.25 mg/day.

==Side Effects==
{| class="wikitable"
!style="text-align: left"| Frequency
!Adverse reactions
|-
| rowspan="5" | '''Common
| Drowsiness
|-
| Dizziness
|-
| Light-headedness
|-
| Headache
|-
| Problems with coordination
|-
| rowspan="7" | '''Serious
| Paradoxical reactions (agitation, aggression)
|-
| Dependence, withdrawal symptoms
|-
| Severe allergic reactions like rash, hives, itching, swelling of the eyes, face, lips, tongue or throat, difficulty breathing or swallowing.
|-
| Profound sedation, respiratory depression, coma and death when used concomitantly with opioids.
|-
| Daytime anxiety
|-
| Depression, suicidal thoughts
|-
| Complex behaviors like "sleep-driving", eating, making phone calls, or having sex with amnesia for these events
|}

==Pharmacokinetics==
*Onset of action:
**Rapid onset of action; peak plasma level are reached within 1 to 2 hours afters oral administration.
*Half-Life: Approximately 1.5 to 5.5 hours.
*MetabolismL Metabolized in the lever primarily via cytochrome P450 enzyme (CYP3A4).
*Excretion: Primarily excreted in urine.

==Drug Precautions==
'''Pregnancy

Potential risk of congenital malformations.

'''Breastfeeding

Excreted in breast milk; not recommended.

'''Children and Elderly

Not recommended for children under 18 years; elderly may require lower doses due to increased sensitivity.

'''Monitoring Requirements

Monitor for signs of respiratory depression, sedation levels, dependence, and withdrawal symptoms.

'''Drug Interactions

Avoid alcohol, opioids, and other CNS depressants; may interact with CYP3A4 inhibitors/inducers.

==FAQ==
'''How Should I Take the Tablet?

Take exactly as prescribed, usually once daily at bedtime. It can be taken with or without food.

'''What Should I Avoid While Taking?

Avoid alcohol and other CNS depressants, and be cautious when driving or operating machinery until you know how triazolam affects you.

'''What Happens if I Miss a Dose?

Take the missed dose as soon as you remember, but skip it if it is close to the next dose. Do not double up.

Triazolam - Revision history

Zeki at 05:51, 26 August 2024

Zeki: Created page with "Category: DrugsCategory: Benzodiazepine '''Antidepressant Drug''' '''Drug class: :Category: Benzodiazepine | Benzodiazepine, B..."