Zeki: /* Drug Precautions */

2024-08-12T02:26:13Z

Drug Precautions

← Older revision		Revision as of 22:26, 11 August 2024
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	\| Moderate		\| Moderate
	\| Antiplatelets		\| Antiplatelets

	Anticoagulants		Anticoagulants

	NSAID		NSAID

	CYP2D6 substrates: dextromethorphan, metoprolol, nebivolol, tolterodine		CYP2D6 substrates: dextromethorphan, metoprolol, nebivolol, tolterodine
	\| Increased bleeding risks		\| Increased bleeding risks

Zeki: /* Drug Precautions */

2024-08-12T02:25:56Z

Drug Precautions

← Older revision		Revision as of 22:25, 11 August 2024
Line 122:		Line 122:
	\| Moderate		\| Moderate
	\| Antiplatelets		\| Antiplatelets

	Anticoagulants		Anticoagulants

	NSAID		NSAID

	CYP2D6 substrates: dextromethorphan, metoprolol, nebivolol, tolterodine		CYP2D6 substrates: dextromethorphan, metoprolol, nebivolol, tolterodine
	\| Increased bleeding risks		\| Increased bleeding risks

Zeki at 02:24, 12 August 2024

2024-08-12T02:24:49Z

← Older revision		Revision as of 22:24, 11 August 2024
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	'''Venlafaxine (EFFEXOR)'''（中文：[[文拉法辛]]）		'''Venlafaxine (EFFEXOR)'''（中文：[[文拉法辛]]）
			==Common Strengths of Venlafaxine==
			Venlafaxine are available in the following strengths:
			*25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg, 150 mg, 225 mg

			==Drug Trade Names of Venlafaxine==
			*Effexor
			*Effexor XR

			==Drug Usage==
			Venlafaxine is used to treat:
			*Major depressive disorder (MDD)
			*Generalized anxiety disorder (GAD)
			*Social anxiety disorder (SAD)
			*Panic disorder (PD)

			==Mechanism of Action==
			Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by inhibiting the reuptake of serotonin and norepinephrine, increasing their levels in the brain.

			==Route of Administration==
			Oral (immediate-release tablets and extended0release capsules)

			==Dosages==
			*Depression: 75 - 225 mg/day
			*Anxiety: 75 - 225 mg/day
			*Panic disorder: 37.5 - 225 mg/day

			Renal dose based on eGFR:
			*eGFR 30 - 89 mL/min: Reduce total daily dose by 25 - 50%
			*eGFR <30 mL/min: Reduce total daily dose by 50% or more

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="9" \| '''Common
			\| Nausea: Stick to simple meals and avoid rich or spicy foods.
			\|-
			\| Dry mouth: Chew sugar-free gum or sweets.
			\|-
			\| Dizziness: Get up slowly from sitting or lying positions
			\|-
			\| Constipation: Increase fiber intake and drink plenty of water
			\|-
			\| Insomnia: Take venlafaxine in the morning
			\|-
			\| Excessive Sweating: Wear loose clothing and use a fan if needed
			\|-
			\| Decreased Appetite
			\|-
			\| Fatigue or Sleepiness
			\|-
			\| Sexual Dysfunction: includes decreased libido and difficulty achieving orgasm
			\|-
			\| rowspan="12" \| '''Serious
			\| '''Serious side effects are less common but require immediate medical attention, These include::'''
			\|-
			\| Suicidal Thoughts or Actions: especially in the first few months of treatment or when the dose is changed. Symptoms include new or worsening depression, anxiety, or unusual changes in mood or behavior.
			\|-
			\| Serotonin Syndrome: This potentially life-threatening condition can occur when there is too much serotonin in the body. Symptoms include agitation, hallucinations, rapid heart rate, fever, nausea, vomiting, diarrhea, and muscle twitching
			\|-
			\| Severe Allergic Reactions: these include symptoms like diffculty breathing, swelling of the face, lips, tongue, or throat, and severe rash or hives.
			\|-
			\| High blood pressure: Regular monitoring is necessary as venlafaxine can increase blood pressure
			\|-
			\| Low sodium level: Symptoms include headache, confusion, weakness, an unsteadiness
			\|-
			\| Bleeding problems: Increased risk when taken with NSAID, aspirin, or anticoagulant
			\|-
			\| Seizures
			\|-
			\| Eye problems: Blurred vision, changes in eyesight, or dilated pupils
			\|-
			\| Heart issues: Fast or irregular heart beat, chest pain
			\|-
			\| Liver problems: Yellowing of the skin or eyes, dark urine, light-colored stools
			\|-
			\| Severe skin reactions: Stevens-Johonson syndrome, toxic epidermal necrolysis
			\|}

			==Pharmacokinetics==
			*Extensively metabolized in the liver
			*Elimination half-life: approximately 5 hours for venlafaxine, 11 hours for its active metabolite
			*Onset: 1 - 4 weeks for full effect

			==Drug Precautions==
			'''Pregnancy

			Use with caution; potential risks to the fetus, especially in the third trimester

			'''Breastfeeding

			Use with caution; venlafaxine is excreted in breast milk

			'''Children and Elderly
			*Not recommended for Children under 18 for depression
			*Elderly may be more sensitive to side effects; lower doses may be needed

			'''Monitoring Requirements
			*Blood pressure
			*Signs of serotonin syndrome
			*Suicidal thoughts or behaviors
			*Liver function

			'''Drug Interactions
			{\| class="wikitable"
			!style="text-align: left"\| Interaction Type
			! Examples
			! Notes
			\|-
			\| Major
			\| Other serotonergic drugs include other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, and St.John's Wort.
			\| Risk of serotonin syndrome
			\|-
			\| Moderate
			\| Antiplatelets

			Anticoagulants

			NSAID

			CYP2D6 substrates: dextromethorphan, metoprolol, nebivolol, tolterodine
			\| Increased bleeding risks
			\|}

			==FAQ==
			'''How Should I Take the Tablet?

			Take the tablet with food, either as a single daily dose or divided into two doses. Extended-release capsules should be taken once daily with food.

			'''What Should I Avoid While Taking?

			Avoid alcohol and operating heavy machinery until you know how venlafaxine affects you. Avoid abrupt discontinuation of the medication.

			'''What Happens if I Miss a Dose?

			Take the missed doses as soon as you remember unless it is almost time for your next dose. Do not double doses,

Zeki at 01:28, 12 August 2024

2024-08-12T01:28:57Z

← Older revision		Revision as of 21:28, 11 August 2024
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	~~==Pronunciation==~~		[[Category: Drugs]][[Category: Serotonin-norepinephrine reuptake inhibitor]]
	~~===Venlafaxin 75mg===~~
	[[~~File~~:~~Venlafaxin 75mg.mp3~~]]		[[:Category: Antidepressant Drug \| '''Antidepressant Drug''']]

			'''Drug class: [[:Category: Serotonin-norepinephrine reuptake inhibitor \| Serotonin-Norepinephrine Reuptake Inhibitor]]

			'''Venlafaxine (EFFEXOR)'''（中文：[[文拉法辛]]）

Zeki: Created page with "==Pronunciation== ===Venlafaxin 75mg=== File:Venlafaxin 75mg.mp3"

2024-08-12T01:28:02Z

Created page with "==Pronunciation== ===Venlafaxin 75mg=== File:Venlafaxin 75mg.mp3"

New page

==Pronunciation==
===Venlafaxin 75mg===
[[File:Venlafaxin 75mg.mp3]]

Venlafaxine - Revision history

Zeki: /* Drug Precautions */

Zeki: /* Drug Precautions */

Zeki at 02:24, 12 August 2024

Zeki at 01:28, 12 August 2024

Zeki: Created page with "==Pronunciation== ===Venlafaxin 75mg=== File:Venlafaxin 75mg.mp3"