Vigabatrin - Revision history

Zeki at 07:38, 29 August 2024

2024-08-29T07:38:20Z

← Older revision		Revision as of 03:38, 29 August 2024
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	\| Severe allergic reactions		\| Severe allergic reactions
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			==Pharmacokinetics==
			*Absorption: Vigabatrin is rapidly absorbed; peak plasma concentrations occur approximately 1 hour after administration.
			*Half-Life: About 5 to 8 hours.
			*Metabolism: Not significantly metabolized; primarily eliminated unchanged.
			*Excretion: Primarily through renal excretion; about 95% of the drug is excreted in urine.

			==Drug Precautions==
			'''Pregnancy

			Potential risks to the fetus.

			'''Breastfeeding

			Excreted in breast milk; caution is advised.

			'''Children and Elderly

			Safety and efficacy established in children; elderly patients may require careful monitoring.

			'''Monitoring Requirements

			Monitor vision periodically, liver function, and signs of mood changes.

			'''Drug Interactions

			Vigabatrin can interact with other medications that affect GABA levels and may increase the risk of CNS depression.

			==FAQ==
			'''How Should I Take the Tablet?

			Take exactly as prescribed, usually with or without food.

			'''What Should I Avoid While Taking?

			Avoid alcohol and other CNS depressants; be cautions when driving or operating machinery until you know how vigabatrin affect you.

			'''What Happens if I Miss a Dose?

			Take the missed dose as soon as you remember, but skip it if it is close to the next dose. Do not double up.

Zeki: /* Side Effects */

2024-08-29T07:07:38Z

Side Effects

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	\| '''Serious Side Effects		\| '''Serious Side Effects
	\|-
	\| The most serious and concerning side effects of vigabatrin is permanent vision loss, including bilateral concentric visual field constriction and decreased visual acuity. This risk increases with higher doses and longer exposure to the drug there is no know safe dose or exposure duration that is free from this risk.		\| The most serious and concerning side effects of vigabatrin is permanent vision loss, including bilateral concentric visual field constriction and decreased visual acuity. This risk increases with higher doses and longer exposure to the drug there is no know safe dose or exposure duration that is free from this risk.
	\|-		\|-

Zeki: /* Side Effects */

2024-08-29T07:07:23Z

Side Effects

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 | The most serious and concerning side effects of vigabatrin is permanent vision loss, including bilateral concentric visual field constriction and decreased visual acuity. This risk increases with higher doses and longer exposure to the drug there is no know safe dose or exposure duration that is free from this risk.
 |-
+| rowspan="5" | '''Other Serious side effects

Zeki: /* Side Effects */

2024-08-29T07:05:27Z

Side Effects

← Older revision		Revision as of 03:05, 29 August 2024
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	\| '''Serious Side Effects		\| '''Serious Side Effects
			\|-
	\| The most serious and concerning side effects of vigabatrin is permanent vision loss, including bilateral concentric visual field constriction and decreased visual acuity. This risk increases with higher doses and longer exposure to the drug there is no know safe dose or exposure duration that is free from this risk.		\| The most serious and concerning side effects of vigabatrin is permanent vision loss, including bilateral concentric visual field constriction and decreased visual acuity. This risk increases with higher doses and longer exposure to the drug there is no know safe dose or exposure duration that is free from this risk.
	\|-		\|-
	\|		\|

Zeki at 07:05, 29 August 2024

2024-08-29T07:05:13Z

← Older revision		Revision as of 03:05, 29 August 2024
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	==Mechanism of Action==		==Mechanism of Action==
	Vigabatrin works by irreversibly inhibiting GABA transaminase, the enzyme responsible		Vigabatrin works by irreversibly inhibiting GABA transaminase, the enzyme responsible for the breakdown of GABA (gamma-aminobutyric acid). This increases the levels of GABA in the brain, which helps stabilize electrical activity and reduce seizures.

			==Route of Administration==
			Oral

			==Dosages==
			*Adults:
			**Complex Partial Seizures: Start with 500 mg orally every 12 hours, increasing by 500 mg increments weekly to a target dose of 1.5 g every 12 hours.

			*Children:
			**Infantile Spasms: Initial dose of 50 mg/kg/day, divided into two doses, with increments every 3 days to a maximum of 150 mg/kg/day.

			*Renal Impairment:
			**Mild (CrCl >50 to 80 mL/min): Decrease dose by 25%.
			**Moderate (CrCl >30 to 50 mL/min): Decrease dose by 50%.
			**Severe (CrCl >10 to 30 mL/min): Decrease dose by 75%.

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="7" \| '''Common Side Effects
			\| Headache
			\|-
			\| Somnolence (Sleepiness)
			\|-
			\| Fatigue
			\|-
			\| Dizziness
			\|-
			\| Weight gain
			\|-
			\| Tremor
			\|-
			\| Visual field defects
			\|-
			\| '''Serious Side Effects
			\| The most serious and concerning side effects of vigabatrin is permanent vision loss, including bilateral concentric visual field constriction and decreased visual acuity. This risk increases with higher doses and longer exposure to the drug there is no know safe dose or exposure duration that is free from this risk.
			\|-
			\|

Zeki at 06:19, 29 August 2024

2024-08-29T06:19:01Z

← Older revision		Revision as of 02:19, 29 August 2024
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	'''Vigabatrin (SABRIL)'''（中文：[[氯己烯酸]]）		'''Vigabatrin (SABRIL)'''（中文：[[氯己烯酸]]）
			==Common Strengths of Vigabatrin==
			Vigabatrin are available in the following strengths:
			*Tablet: 500 mg

			==Drug Trade Names of Vigabatrin==
			Sabril

			==Drug Usage==
			Vigabatrin is used for:
			*Treatment of refractory complex partial seizures in adults and children aged 2 years and older.
			*Treatment of infantile spasms in infants aged 1 month to 2 years.

			==Mechanism of Action==
			Vigabatrin works by irreversibly inhibiting GABA transaminase, the enzyme responsible

Zeki at 05:41, 29 August 2024

2024-08-29T05:41:25Z

← Older revision		Revision as of 01:41, 29 August 2024
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	[[Category: ~~Drug~~]][[Category: Anticonvulsant]]		[[Category: Drugs]][[Category: Anticonvulsant]]

			'''Drug class: [[:Category: Anticonvulsant \| Anticonvulsant]]

			'''Vigabatrin (SABRIL)'''（中文：[[氯己烯酸]]）

Zeki: Created page with "Category: DrugCategory: Anticonvulsant"

2024-08-29T05:32:40Z

Created page with "Category: Drug Category: Anticonvulsant"

New page

[[Category: Drug]][[Category: Anticonvulsant]]