Helen: /* Drug Precautions */

2024-07-05T05:57:53Z

Drug Precautions

← Older revision		Revision as of 01:57, 5 July 2024
Line 101:		Line 101:

	'''Drug interactions		'''Drug interactions

	Low potential for interactions, but caution with insulin or sulfonylureas		Low potential for interactions, but caution with insulin or sulfonylureas

Zeki at 08:04, 4 July 2024

2024-07-04T08:04:26Z

← Older revision		Revision as of 04:04, 4 July 2024
Line 6:		Line 6:

	'''Vildagliptin (GALVUS)'''（中文：[[維格列汀]]）		'''Vildagliptin (GALVUS)'''（中文：[[維格列汀]]）
			==Common Strengths of Vildagliptin Tablet==
			Vildagliptin tablets are available in the following strengths:
			*50 mg tablets

			==Drug Trade Names of Vildagliptin Tablet==
			Galvus is the trade name for Vildagliptin.

			It is also sold under various brand names when combined with other antidiabetic medications, such as:
			*GALVUS MET TABLET 50/1000MG: Vildagliptin 50mg + Metformin 1000mg
			*GALVUS MET TABLET 50/500MG: Vildagliptin 50mg + Metformin 500mg
			*GALVUS MET TABLET 50/850MG: Vildagliptin 50mg + Metformin 850mg

			==Drug Usage==
			Treatment of type 2 diabetes mellitus in adults, as an adjunct to diet and exercise.

			==Mechanism of Action==
			Inhibits DPP-4 enzyme, increasing levels of incretin hormones (GLP-1 and GIP), which stimulate insulin release and decrease glucagon secretion, thereby lowering blood glucose.

			==Route of Administration==
			Oral

			==Dosages==
			*50 mg twice daily
			*No specific dosage adjustments for hypertension or heart failure
			*For diabetic kidney disease (renal impairment):
			**Mild (eGFR ≥60 mL/min/1.73 m<sup>2</sup>): No dosage adjustment is required. The recommended dose is 50 mg twice daily
			**Moderate (eGFR 30 to <60 mL/min/1.73 m<sup>2</sup>): 50 mg once daily
			**Severe (eGFR <30 mL/min/1.73 m<sup>2</sup>): 50 mg once daily

			==Side Effects==
			{\| class="wikitable"
			!style="text-align: left"\| Frequency
			!Adverse reactions
			\|-
			\| rowspan="4" \| '''Common
			\| Headache
			\|-
			\| Dizziness
			\|-
			\| Tremor
			\|-
			\| Nausea
			\|-
			\| rowspan="5" \| '''Uncommon
			\| Hypoglycemia
			\|-
			\| Weight gain
			\|-
			\| Constipation
			\|-
			\| Pancreatitis
			\|-
			\| Hepatitis
			\|}

			==Pharmacokinetics==
			*Absorption
			**Rapidly absorbed, 85% bioavailable. Maximum inhibition of DPP-4 activity is seen 30 minutes after a vildagliptin dose.
			*Metabolism
			**Primarily hydrolysis, minimal CYP450 involvement
			*Elimination
			**Mainly renal excretion, half-life approximately 3 hours.
			≥50% inhibition of DPP-4 continues for 10 hours.

			==Drug Precautions==
			'''Pregnancy

			Not recommended, limited data available.

			'''Breastfeeding

			Not recommended.

			'''Children and Elderly
			*Children: Not recommended for use in children <18 years
			*Elderly: No dose adjustment is required, but use with caution

			'''Renal Impairment

			Dose adjustment required for moderate to severe impairment (refer to dosage section).

			'''Monitoring Requirements
			*Liver function
			*Blood glucose
			*HbA1c
			*Signs of pancreatitis
			The main symptoms of pancreatitis include:
			*Severe abdominal pain, typically in the upper abdomen, that may:
			**Feel worse after eating
			**Be sudden and intense in acute cases
			*Nausea and vomiting
			*Fever
			*Rapid pulse/heart rate

			'''Drug interactions
			Low potential for interactions, but caution with insulin or sulfonylureas

			==FAQ==
			'''How Should I Take the Tablet?

			Take twice daily with or without food.

			'''What Should I Avoid While Taking?

			Alcohol (may increase risk of hypoglycemia).

			'''What Happens if I Miss a Dose?

			Take as soon as remembered unless close to next dose, do not double dose

Zeki: Created page with "Category: DrugsCategory: Dipeptidyl peptidase-4 (DPP-4) inhibitor '''Antidiabetic Drug''' '''Drug class: :Category: Dipeptidyl p..."

2024-07-04T07:47:48Z

Created page with "Category: Drugs Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor '''Antidiabetic Drug''' '''Drug class: :Category: Dipeptidyl p..."

New page

[[Category: Drugs]][[Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

[[:Category: Antidiabetic Drug | '''Antidiabetic Drug''']]

'''Drug class: [[:Category: Dipeptidyl peptidase-4 (DPP-4) inhibitor | Dipeptidyl peptidase-4 (DPP-4) inhibitor]]

'''Vildagliptin (GALVUS)'''（中文：[[維格列汀]]）

Vildagliptin - Revision history

Helen: /* Drug Precautions */

Zeki at 08:04, 4 July 2024

Zeki: Created page with "Category: DrugsCategory: Dipeptidyl peptidase-4 (DPP-4) inhibitor '''Antidiabetic Drug''' '''Drug class: :Category: Dipeptidyl p..."